This is the analysis script to prepare the data to run analyses for the project “Anxiety, depression and trauma symptom change during the COVID-19 pandemic: retrospective versus objective assessment” - Young et al (2020)

Script written by K L Purves, K N Thompson, C Huebel and M Davies. Email: , , ,

#Set up

Clear global environment

Retrieve the current date to use it for file endings to not overwrite files when one exports files

#Packages Install packages (if they are not available in your version of R)

Load packages

Registered S3 method overwritten by 'pryr':
  method      from
  print.bytes Rcpp
For best results, restart R session and update pander using devtools:: or remotes::install_github('rapporter/pander')

Attaching package: 'polycor'
The following object is masked from 'package:psych':

    polyserial
corrplot 0.84 loaded
── Attaching packages ─────────────────────────────────────── tidyverse 1.3.0 ──
✓ ggplot2 3.3.2     ✓ purrr   0.3.4
✓ tibble  3.0.4     ✓ dplyr   1.0.2
✓ tidyr   1.1.2     ✓ stringr 1.4.0
✓ readr   1.3.1     ✓ forcats 0.5.0
── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ──
x ggplot2::%+%()   masks psych::%+%()
x ggplot2::alpha() masks psych::alpha()
x dplyr::filter()  masks stats::filter()
x dplyr::lag()     masks stats::lag()
x tibble::view()   masks summarytools::view()

R functions

        FunctionLib/lm_forest.R FunctionLib/lm_formula.R
value   ?                       ?                       
visible FALSE                   FALSE                   
        FunctionLib/lm_output.R FunctionLib/raincloud.R
value   ?                       ?                      
visible FALSE                   FALSE

Half-violin plot

Colour palettes

Define colours for plotting this are the standard coping colours

Choose in this chunk which palette to use 04.07.2020 - Default to 2 colour COPING palette

ggplot theme

Set up ggplot theme for the plots

Data import

Source data file paths

Read in data

[1] 34465   643

Important vectors with collections of columns

Vectors for sum_score

 [1] "gad.sum_score_prepan"        "pcl.sum_score_prepan"       
 [3] "phq.sum_score_prepan"        "phq.sum_score_8items_prepan"
 [5] "ocir.sum_score_prepan"       "gad.sum_score_base"         
 [7] "gad.sum_score_retro"         "pcl.sum_score_base"         
 [9] "pcl.sum_score_retro"         "phq.sum_score_base"         
[11] "phq.sum_score_8items_base"   "phq.sum_score_retro"        
[13] "phq.sum_score_8items_retro"  "ocir.sum_score_base"        
[15] "ocir.sum_score_retro"       
[1] "phq.sum_score_prepan" "phq.sum_score_base"   "phq.sum_score_retro" 
[1] "gad.sum_score_prepan" "gad.sum_score_base"   "gad.sum_score_retro" 
[1] "ocir.sum_score_prepan" "ocir.sum_score_base"   "ocir.sum_score_retro" 
[1] "pcl.sum_score_prepan" "pcl.sum_score_base"   "pcl.sum_score_retro"

Vectors for diff_score

 [1] "phq.diff_score_retro_prepan"  "phq.diff_score_base_prepan"  
 [3] "phq.diff_score_base_retro"    "gad.diff_score_retro_prepan" 
 [5] "gad.diff_score_base_prepan"   "gad.diff_score_base_retro"   
 [7] "pcl.diff_score_base_prepan"   "ocir.diff_score_retro_prepan"
 [9] "ocir.diff_score_base_prepan"  "ocir.diff_score_base_retro"  
[1] "phq.diff_score_retro_prepan" "phq.diff_score_base_prepan" 
[3] "phq.diff_score_base_retro"  
[1] "gad.diff_score_retro_prepan" "gad.diff_score_base_prepan" 
[3] "gad.diff_score_base_retro"  
[1] "ocir.diff_score_retro_prepan" "ocir.diff_score_base_prepan" 
[3] "ocir.diff_score_base_retro"

Create subsets of data for analyses

Filter data frame to create 2 additional datasets. Additional exclusion criteria (beyond those listed above) are specified below:

  1. Retrospective - baseline change anlyses
    1. Exclude individuals missing retrospective and/or baseline data
  2. Prepandemic - baseline change analyses i. Exclude individuals missing pandemic and/or baseline data ii. Exclude individuals with prepandemic data collected after 1st March.

Retro-baseline analyses

Note: make sure we impute retrospective data for those who did not change their feelings

Important note::: PCL does not have retrospective data, so we allow Baseline only or All prepandemic, baseline and retrospective OR Baseline and prepandemic data. Important logic here is that we need EVRYONE with ANY baseline data, but dont care about any other time point for this retrospective dataset for PCL.

[1] 32737   643

Prepan-baseline analyses Exclude individuals with NA for MHD, age, gender; exclude if prepan data collected after 1 March

[1] 12157   643

Prepan-baseline analyses Exclude individuals with NA for MHD, age, gender; exclude if prepan data collected after 1 March (to ensure comparability with prepan analyses)

[1] 10489   643

age^2 sensitivity Exclude individuals with NA for continuous Age variable

[1] 25814   643
[1] 24096   643
[1] 12157   643

Sensitivity analysis for individuals who signed up to GLAD (prepan) either 3, 6 or 9 months before the pendemic began.

#ANALYSIS PLAN 1. Calculate mean change per disorder group i. Disorders (9) a. Rank the disorders by the size of the change ii. Sex iii. Age (13; RAMP; potentially collapse above 65 depending on group sizes) iv. Ethnicity groups (5; White European, Black (British), Asian, Arab, Mixed)

1. Questionnaire comparions: Calculate mean change per group

gad

Summary scores

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf
Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Table for knitting gad sum score summary table

Change Variable Min Max Mean Median SD Skew Kurtosis
No change Base 0 21 2.740042 1 4.481334 2.1348352 4.2519780
No change Prepan 0 21 7.993625 7 6.165962 0.5274724 -0.8425302
No change Retro 0 21 2.740042 1 4.481334 2.1348352 4.2519780
Worsening Base 0 21 8.766138 7 5.693132 0.5145419 -0.8093878
Worsening Prepan 0 21 9.160358 8 5.869416 0.3772128 -0.9054598
Worsening Retro 0 21 4.658218 4 4.263868 1.3773597 1.9563781
Improvement Base 0 21 4.767912 3 4.832619 1.3721605 1.5870653
Improvement Prepan 0 21 9.046937 8 5.804418 0.3595536 -0.8773999
Improvement Retro 0 21 8.337588 7 5.489836 0.5192540 -0.5883912
NA Base 0 21 5.722222 5 5.816102 1.0412406 0.2319193
NA Prepan 0 21 10.000000 13 8.563488 -0.0313927 -1.9895986
NA Retro Inf -Inf NaN NA NA NA NA

Differences scores

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf

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Table for knitting gad diff summary table

Change Variable Min Max Mean Median SD Skew Kurtosis
No change Base - prepan -21 20 -2.0355457 -1 4.695963 -0.4873054 1.5249971
No change Base - retro Inf -Inf NaN NA NA NA NA
No change Prepan - retro Inf -Inf NaN NA NA NA NA
Worsening Base - prepan -18 21 1.0244339 1 5.272565 -0.0232123 0.6264062
Worsening Base - retro -21 21 4.1083717 3 4.319494 0.7492612 0.9033930
Worsening Prepan - retro -21 18 -3.4649078 -3 5.071721 -0.3175882 0.4750981
Improvement Base - prepan -21 12 -3.9601911 -3 5.470385 -0.2955275 0.1734936
Improvement Base - retro -21 21 -3.5651408 -3 5.333376 0.4506964 2.0385927
Improvement Prepan - retro -21 20 0.4334661 1 5.679098 -0.1488051 0.8650700
NA Base - prepan -9 6 -1.5000000 -2 5.431390 0.0468089 -1.6798094
NA Base - retro Inf -Inf NaN NA NA NA NA
NA Prepan - retro Inf -Inf NaN NA NA NA NA

Long format

Plots diff

makes this into percentages

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Plots sum

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Violin plots

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phq

Summary scores

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf
Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Table for knitting phq sum score summary table

Phq.change_binary Variable Min Max Mean Median SD Skew Kurtosis
No change Base 0 27 3.911637 2 5.561495 1.9710470 3.5614983
No change Prepan 0 27 10.331368 9 7.165943 0.5042461 -0.7025645
No change Retro 0 27 3.911637 2 5.561495 1.9710470 3.5614983
Worsening Base 0 27 10.464944 9 6.597026 0.5728307 -0.5587612
Worsening Prepan 0 27 11.544677 11 6.734044 0.3283080 -0.7571665
Worsening Retro 0 27 5.764678 4 5.272585 1.4108842 1.9270712
Improvement Base 0 27 6.736196 5 5.756886 1.0578823 0.6962716
Improvement Prepan 0 27 11.416949 11 6.732361 0.3159912 -0.8068586
Improvement Retro 0 27 9.761905 9 6.750091 0.6105814 -0.4259463
NA Base 0 27 6.360760 4 7.081166 1.0612878 0.0689664
NA Prepan 0 25 10.675676 8 7.476088 0.5644682 -0.9990107
NA Retro Inf -Inf NaN NA NA NA NA

Differences score

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf
Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Warning in max(., na.rm = T): no non-missing arguments to max; returning -Inf

Table for knitting phq diff summary table

Phq.change_binary Variable Min Max Mean Median SD Skew Kurtosis
No change Base - prepan -25 23 -1.9953315 -1 5.121711 -0.3442067 1.7614748
No change Base - retro Inf -Inf NaN NA NA NA NA
No change Prepan - retro Inf -Inf NaN NA NA NA NA
Worsening Base - prepan -23 24 0.8652563 1 5.564097 -0.0442397 0.8979642
Worsening Base - retro -18 27 4.6967453 4 4.598109 0.8998863 1.2437470
Worsening Prepan - retro -27 21 -4.1668767 -4 5.496903 -0.3745911 0.6142949
Improvement Base - prepan -23 14 -4.0088195 -3 5.680142 -0.4391773 0.2052763
Improvement Base - retro -24 23 -3.0184403 -3 5.566698 0.0409481 1.8189755
Improvement Prepan - retro -27 22 -0.1250850 0 6.156186 -0.0477601 0.6905753
NA Base - prepan -21 8 -0.5277778 0 5.794017 -1.1586641 2.3722947
NA Base - retro Inf -Inf NaN NA NA NA NA
NA Prepan - retro Inf -Inf NaN NA NA NA NA

Long format

Plots

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Plots sum

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Violin plots

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ocir

Summary scores

Warning in min(., na.rm = T): no non-missing arguments to min; returning Inf
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Table for knitting ocir sum score summary table

Variable Min Max Mean Median SD Skew Kurtosis
Base 0 72 18.16106 15 13.01856 1.111240 1.1222355
Prepan 1 71 27.05217 25 14.08570 0.636545 -0.0069965
Retro 0 71 16.76087 14 12.74079 1.120438 1.0346803

Differences scores

Table for knitting ocir diff summary table

Variable Min Max Mean Median SD Skew Kurtosis
Base - prepan -40 34 -8.084711 -7 10.701437 -0.1437180 0.6496048
Base - retro -44 72 1.466054 1 9.784785 0.2935243 2.3017255
Prepan - retro -30 27 -3.596491 -3 9.288374 -0.0831304 0.3781195

Long format

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makes this into percentages

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Plots sum

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Violin plots

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++CH: Rank the disorders by the size of the change

PCL: Calculate the total GLAD, COPING, RAMP baseline ## PCL

Table for knitting pcl sum score summary table

Variable Min Max Mean Median SD Skew Kurtosis
Base - prepan -23 24 0.2218057 0 5.663535 -0.0680983 0.6666216

Table for knitting pcl diff summary table

Variable Min Max Mean Median SD Skew Kurtosis
Base 6 30 12.45841 11 6.036574 0.9034948 -0.0705604
Prepan 6 30 15.45255 15 6.109940 0.4074959 -0.7142112

For each item present percentages of how say that this is due to the pandemic

PCL Item Binary_score n prop n_prop
pcl.cut_people_feeling_distant_retro_numeric 0 6592 19.1 6592 (19.1%)
pcl.cut_people_feeling_distant_retro_numeric 1 16928 49.1 16928 (49.1%)
pcl.cut_people_feeling_distant_retro_numeric Missing 10945 31.8 10945 (31.8%)
pcl.difficulty_concentrating_retro_numeric 0 10912 31.7 10912 (31.7%)
pcl.difficulty_concentrating_retro_numeric 1 11352 32.9 11352 (32.9%)
pcl.difficulty_concentrating_retro_numeric Missing 12201 35.4 12201 (35.4%)
pcl.feeling_irritable_or_having_angry_outbursts_retro_numeric 0 9685 28.1 9685 (28.1%)
pcl.feeling_irritable_or_having_angry_outbursts_retro_numeric 1 10903 31.6 10903 (31.6%)
pcl.feeling_irritable_or_having_angry_outbursts_retro_numeric Missing 13877 40.3 13877 (40.3%)
pcl.stressful_experience_repeated_images_retro_numeric 0 14517 42.1 14517 (42.1%)
pcl.stressful_experience_repeated_images_retro_numeric 1 3204 9.3 3204 (9.3%)
pcl.stressful_experience_repeated_images_retro_numeric Missing 16744 48.6 16744 (48.6%)
pcl.stressful_experience_upset_reminded_retro_numeric 0 15284 44.3 15284 (44.3%)
pcl.stressful_experience_upset_reminded_retro_numeric 1 4076 11.8 4076 (11.8%)
pcl.stressful_experience_upset_reminded_retro_numeric Missing 15105 43.8 15105 (43.8%)
pcl.stressful_situation_avoiding_activities_retro_numeric 0 10199 29.6 10199 (29.6%)
pcl.stressful_situation_avoiding_activities_retro_numeric 1 2687 7.8 2687 (7.8%)
pcl.stressful_situation_avoiding_activities_retro_numeric Missing 21579 62.6 21579 (62.6%)

Plots sum

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Violin plots

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  1. Regression models (Regress covariates out of the change? Which?)

    1. Model 0: Disorders
    2. Model 1: Model 0 + Sex + Age + Ethnicity + Time registration and baseline

  2. Re-calculate change

  3. Re-rank the change again

  4. PCL:

    1. Calculate the total GLAD, COPING, RAMP baseline
    2. For each item:
      1. present percentages of how say that this is due to the pandemic
      2. Calculate a variable PCL pandemic score
      3. If one item is highly endorsed due to pandemic -> exclude in sensitivity analysis

2. Regression

Regress covariates out of the change? Which?

Model naming conventions: 0 - unadjusted 1 - adjusted 2 - adjusted with age^2 a - hierarchical disorders b - overlapping disorder categories

++MD: We may want to exclude disorders from Model b that aren’t including in the hierarchy (e.g. ADHD, ASD)

Functions

GAD baseline, not controlling for prior symptoms

Model 0a: Disorder_hierarchical, Unadjusted

#SB Hashing out this chunk of code as it is not included in our final analysis and is currently breaking the code.

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.67 2.59 2.76 0.04 0.00e+00
Depressive and anxiety disorder 5.63 5.50 5.77 0.07 0.00e+00
Only depressive disorder 2.08 1.90 2.25 0.09 4.32e-117
Only anxiety disorder 4.03 3.81 4.26 0.11 1.97e-264
Eating disorders 1.46 1.22 1.69 0.12 1.10e-33
OCDs 1.94 1.71 2.17 0.12 8.53e-63
Psychotic and bipolar disorder 0.38 -0.26 1.02 0.33 0.24
Only psychotic disorder 0.35 -0.20 0.90 0.28 0.21
Only bipolar disorder 0.46 0.11 0.80 0.18 0.009
PTSD 1.56 1.35 1.77 0.11 2.35e-48
ASD 2.18 1.77 2.59 0.21 1.80e-25
ADHD 1.17 0.63 1.71 0.28 2.36e-05
Personality disorder 2.19 1.89 2.49 0.15 5.79e-46
n R2 adjust. R2 F p value df
32679 0.21 0.21 1485.53 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.67 5.38 5.95 0.15 8.10e-322
Anxiety disorders 2.98 2.73 3.24 0.13 4.34e-113
Eating disorders 2.03 1.23 2.83 0.41 7.12e-07
OCDs 3.86 3.22 4.51 0.33 1.71e-31
PTSD 4.12 3.48 4.77 0.33 2.04e-36
Depressive disorders 4.43 4.30 4.57 0.07 0.00e+00
Bipolar disorders 5.91 5.60 6.22 0.16 1.45e-297
Female 1.01 0.87 1.15 0.07 5.89e-47
Non-binary/Self-defined 1.56 1.01 2.10 0.28 2.71e-08
age_category_collapsed_reordered16-18 3.23 2.86 3.60 0.19 6.52e-66
19-25 years 1.71 1.46 1.97 0.13 4.87e-40
36-45 years -0.83 -1.04 -0.62 0.11 1.54e-14
46-55 years -1.56 -1.75 -1.36 0.10 7.98e-55
56-65 years -2.58 -2.78 -2.39 0.10 9.71e-149
66-70 years -3.55 -3.80 -3.30 0.13 3.76e-172
71-75 years -3.77 -4.05 -3.48 0.15 6.98e-147
76+ years -3.74 -4.17 -3.31 0.22 3.16e-64
Mixed or multiple ethnic origins 0.01 -0.43 0.45 0.22 0.97
Asian or Asian British -0.41 -0.95 0.13 0.28 0.13
African or African British -0.26 -1.24 0.72 0.50 0.61
Other ethnicity 0.75 0.00 1.50 0.38 0.05
Time difference: Lockdown to baseline -0.24 -0.27 -0.21 0.01 9.28e-58
n R2 adjust. R2 F p value df
32679 0.21 0.21 1485.53 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.58 5.29 5.86 0.14 2.34e-318
Depressive and anxiety disorder 4.60 4.45 4.74 0.07 0.00e+00
Only depressive disorder 1.81 1.62 1.99 0.09 5.09e-83
Only anxiety disorder 3.04 2.81 3.28 0.12 2.89e-144
Eating disorders 0.90 0.67 1.13 0.12 3.74e-14
OCDs 1.45 1.23 1.67 0.11 5.39e-37
Psychotic and bipolar disorder 0.74 0.11 1.36 0.32 0.02
Only psychotic disorder 0.51 -0.03 1.05 0.27 0.06
Only bipolar disorder 0.65 0.31 0.98 0.17 1.82e-04
PTSD 1.58 1.38 1.79 0.11 1.17e-50
ASD 1.31 0.90 1.71 0.21 3.02e-10
ADHD 0.46 -0.08 0.99 0.27 0.09
Personality disorder 1.82 1.52 2.11 0.15 2.67e-33
Female 0.94 0.80 1.07 0.07 2.39e-42
Non-binary/Self-defined 0.68 0.14 1.22 0.28 0.01
age_category_collapsed_reordered16-18 3.33 2.97 3.68 0.18 1.18e-75
19-25 years 1.61 1.37 1.86 0.13 1.95e-37
36-45 years -0.64 -0.85 -0.44 0.11 1.14e-09
46-55 years -1.15 -1.34 -0.96 0.10 1.07e-31
56-65 years -2.02 -2.21 -1.83 0.10 4.70e-93
66-70 years -2.98 -3.23 -2.73 0.13 6.61e-121
71-75 years -3.21 -3.49 -2.93 0.14 4.74e-108
76+ years -3.09 -3.51 -2.66 0.22 1.77e-46
Mixed or multiple ethnic origins 0.09 -0.34 0.52 0.22 0.67
Asian or Asian British 0.15 -0.36 0.67 0.26 0.56
African or African British -0.35 -1.28 0.59 0.48 0.47
Other ethnicity 0.78 0.02 1.53 0.38 0.04
Key worker -0.35 -0.47 -0.22 0.06 3.75e-08
Time difference: Lockdown to baseline -0.25 -0.27 -0.22 0.01 2.58e-65
n R2 adjust. R2 F p value df
32679 0.21 0.21 1485.53 0.00e+00 6

Model 2a: Disorder hierarchical, Adjusted with Age^2

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.68 1.38 1.99 0.15 1.35e-27
Anxiety disorders 2.79 2.49 3.10 0.16 7.42e-72
Eating disorders 2.19 1.26 3.11 0.47 3.36e-06
OCDs 4.45 3.65 5.24 0.41 7.43e-28
PTSD 4.13 3.27 4.98 0.44 3.62e-21
Depressive disorders 4.67 4.51 4.82 0.08 0.00e+00
Bipolar disorders 6.05 5.72 6.38 0.17 2.09e-269
Female 0.72 0.57 0.87 0.08 8.83e-22
Non-binary/Self-defined 1.45 0.86 2.03 0.30 1.49e-06
Age -252.22 -263.35 -241.08 5.68 0.00e+00
Age^2 28.67 18.60 38.73 5.14 2.40e-08
Mixed or multiple ethnic origins -0.02 -0.50 0.46 0.25 0.94
Asian or Asian British -0.09 -0.74 0.55 0.33 0.78
African or African British 0.07 -0.98 1.12 0.54 0.90
Other ethnicity 1.23 0.37 2.10 0.44 0.005
Time difference: Lockdown to baseline 0.06 0.02 0.09 0.02 0.003
n R2 adjust. R2 F p value df
25356 0.26 0.26 1506.65 0.00e+00 6

Model 2b: Disorder hierarchical, Adjusted with Age^2

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.88 1.58 2.17 0.15 3.06e-35
Depressive and anxiety disorder 4.90 4.74 5.06 0.08 0.00e+00
Only depressive disorder 1.98 1.77 2.18 0.10 1.43e-78
Only anxiety disorder 3.02 2.75 3.29 0.14 3.45e-104
Eating disorders 1.09 0.84 1.34 0.13 2.26e-17
OCDs 1.38 1.13 1.62 0.12 8.67e-29
Psychotic and bipolar disorder 0.44 -0.27 1.15 0.36 0.23
Only psychotic disorder 0.48 -0.10 1.06 0.30 0.10
Only bipolar disorder 0.64 0.29 0.99 0.18 3.50e-04
PTSD 1.69 1.47 1.92 0.11 3.99e-49
ASD 1.24 0.78 1.71 0.24 1.45e-07
ADHD 0.25 -0.37 0.87 0.32 0.43
Personality disorder 1.75 1.43 2.06 0.16 4.75e-27
Female 0.60 0.45 0.74 0.07 3.86e-16
Non-binary/Self-defined 0.54 -0.03 1.12 0.30 0.07
Age -213.75 -225.08 -202.42 5.78 2.54e-290
Age^2 19.85 9.76 29.94 5.15 1.15e-04
Mixed or multiple ethnic origins 0.00 -0.47 0.48 0.24 0.99
Asian or Asian British 0.34 -0.28 0.95 0.31 0.28
African or African British -0.07 -1.08 0.93 0.51 0.89
Other ethnicity 1.08 0.21 1.95 0.44 0.01
Key worker -0.35 -0.49 -0.22 0.07 2.62e-07
Time difference: Lockdown to baseline 0.05 0.02 0.09 0.02 0.004
n R2 adjust. R2 F p value df
25356 0.26 0.26 1506.65 0.00e+00 6

GAD prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.16 -2.08 -0.23 0.47 0.01
Anxiety disorders 0.20 -0.83 1.22 0.52 0.71
Eating disorders -0.55 -2.53 1.42 1.01 0.58
OCDs 0.08 -1.30 1.45 0.70 0.91
PTSD -0.04 -1.62 1.54 0.80 0.96
Depressive disorders 0.90 -0.03 1.84 0.48 0.06
Bipolar disorders 0.82 -0.18 1.82 0.51 0.11
n R2 adjust. R2 F p value df
12006 0.00 0.00 3.23 0.004 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.83 -1.51 -0.16 0.34 0.02
Depressive and anxiety disorder 0.45 -0.24 1.13 0.35 0.20
Only depressive disorder 0.98 0.24 1.72 0.38 0.009
Only anxiety disorder -0.24 -1.01 0.53 0.40 0.54
Eating disorders 0.18 -0.15 0.51 0.17 0.29
OCDs -0.26 -0.57 0.05 0.16 0.11
Psychotic and bipolar disorder -0.51 -1.42 0.39 0.46 0.27
Only psychotic disorder 0.76 0.00 1.52 0.39 0.05
Only bipolar disorder 0.20 -0.26 0.65 0.23 0.40
PTSD 0.14 -0.16 0.43 0.15 0.36
ASD 0.16 -0.44 0.76 0.31 0.61
ADHD -0.74 -1.56 0.09 0.42 0.08
Personality disorder -0.16 -0.57 0.24 0.21 0.43
n R2 adjust. R2 F p value df
12006 0.00 0.00 3.23 0.004 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.41 -2.49 -0.34 0.55 0.01
Anxiety disorders 0.13 -0.90 1.15 0.52 0.80
Eating disorders -0.70 -2.68 1.27 1.01 0.49
OCDs -0.02 -1.40 1.35 0.70 0.97
PTSD -0.19 -1.78 1.39 0.81 0.81
Depressive disorders 0.79 -0.14 1.73 0.48 0.10
Bipolar disorders 0.77 -0.23 1.77 0.51 0.13
Female 0.45 0.19 0.72 0.13 6.41e-04
Non-binary/Self-defined 0.48 -0.28 1.24 0.39 0.21
age_category_collapsed_reordered16-18 -0.59 -1.24 0.06 0.33 0.08
19-25 years 0.05 -0.30 0.40 0.18 0.77
36-45 years 0.19 -0.11 0.50 0.15 0.21
46-55 years -0.01 -0.30 0.29 0.15 0.95
56-65 years 0.14 -0.19 0.47 0.17 0.41
66-70 years -0.25 -0.83 0.32 0.29 0.39
71-75 years -0.32 -1.07 0.44 0.39 0.41
76+ years 0.36 -1.04 1.77 0.72 0.61
Mixed or multiple ethnic origins 0.25 -0.43 0.93 0.35 0.48
Asian or Asian British -0.35 -1.47 0.77 0.57 0.54
African or African British -1.32 -3.12 0.47 0.92 0.15
Other ethnicity 0.07 -0.96 1.09 0.52 0.90
Time difference: Lockdown to baseline -0.01 -0.07 0.05 0.03 0.82
n R2 adjust. R2 F p value df
12006 0.00 0.00 3.23 0.004 6

Model 1b: Overlapping disorders, Adjusted

Model 1b + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.18 -2.07 -0.29 0.46 0.010
Depressive and anxiety disorder 0.38 -0.31 1.07 0.35 0.28
Only depressive disorder 0.92 0.17 1.67 0.38 0.02
Only anxiety disorder -0.29 -1.07 0.49 0.40 0.46
Eating disorders 0.14 -0.20 0.47 0.17 0.42
OCDs -0.26 -0.58 0.05 0.16 0.10
Psychotic and bipolar disorder -0.39 -1.30 0.52 0.47 0.40
Only psychotic disorder 0.79 0.02 1.55 0.39 0.04
Only bipolar disorder 0.29 -0.17 0.75 0.23 0.21
PTSD 0.11 -0.18 0.41 0.15 0.46
ASD 0.25 -0.36 0.87 0.31 0.41
ADHD -0.72 -1.55 0.10 0.42 0.09
Personality disorder -0.19 -0.60 0.22 0.21 0.36
Female 0.46 0.18 0.74 0.14 0.001
Non-binary/Self-defined 0.46 -0.33 1.25 0.40 0.26
age_category_collapsed_reordered16-18 -0.49 -1.16 0.17 0.34 0.14
19-25 years 0.04 -0.32 0.41 0.18 0.81
36-45 years 0.12 -0.20 0.43 0.16 0.47
46-55 years -0.09 -0.40 0.22 0.16 0.55
56-65 years 0.09 -0.26 0.44 0.18 0.63
66-70 years -0.33 -0.95 0.28 0.31 0.29
71-75 years -0.30 -1.11 0.51 0.41 0.46
76+ years 0.38 -1.19 1.94 0.80 0.64
Mixed or multiple ethnic origins 0.32 -0.40 1.04 0.37 0.39
Asian or Asian British -0.18 -1.35 0.98 0.60 0.76
African or African British -1.66 -3.52 0.20 0.95 0.08
Other ethnicity 0.06 -1.03 1.14 0.55 0.92
Key worker 0.17 -0.05 0.39 0.11 0.12
Time difference: Lockdown to baseline -0.01 -0.07 0.06 0.03 0.86
n R2 adjust. R2 F p value df
12006 0.00 0.00 3.23 0.004 6

Model 2a: Disorder hierarchical, Adjusted with Age^2

Model 0a + Gender_collapsed + age^2+ Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.38 -2.44 -0.32 0.54 0.01
Anxiety disorders 0.14 -0.89 1.16 0.52 0.80
Eating disorders -0.69 -2.67 1.28 1.01 0.49
OCDs -0.01 -1.39 1.36 0.70 0.98
PTSD -0.16 -1.74 1.43 0.81 0.85
Depressive disorders 0.81 -0.13 1.74 0.48 0.09
Bipolar disorders 0.78 -0.22 1.78 0.51 0.13
Female 0.46 0.19 0.72 0.13 6.30e-04
Non-binary/Self-defined 0.49 -0.28 1.25 0.39 0.21
Age 0.97 -10.17 12.12 5.69 0.86
Age^2 -10.43 -21.32 0.47 5.56 0.06
Mixed or multiple ethnic origins 0.25 -0.43 0.93 0.35 0.47
Asian or Asian British -0.35 -1.47 0.77 0.57 0.54
African or African British -1.32 -3.12 0.47 0.92 0.15
Other ethnicity 0.06 -0.97 1.08 0.52 0.91
Time difference: Lockdown to baseline -0.01 -0.07 0.05 0.03 0.78
n R2 adjust. R2 F p value df
12006 0.00 0.00 3.23 0.004 6

Model 2b: Overlapping disorders, Adjusted with Age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.20 -2.06 -0.33 0.44 0.007
Depressive and anxiety disorder 0.40 -0.28 1.09 0.35 0.25
Only depressive disorder 0.95 0.20 1.69 0.38 0.01
Only anxiety disorder -0.27 -1.05 0.51 0.40 0.49
Eating disorders 0.13 -0.20 0.47 0.17 0.43
OCDs -0.26 -0.58 0.05 0.16 0.10
Psychotic and bipolar disorder -0.40 -1.32 0.51 0.47 0.39
Only psychotic disorder 0.79 0.03 1.55 0.39 0.04
Only bipolar disorder 0.28 -0.17 0.74 0.23 0.22
PTSD 0.10 -0.19 0.40 0.15 0.50
ASD 0.24 -0.37 0.85 0.31 0.44
ADHD -0.72 -1.55 0.10 0.42 0.09
Personality disorder -0.18 -0.59 0.23 0.21 0.38
Female 0.46 0.18 0.74 0.14 0.001
Non-binary/Self-defined 0.46 -0.33 1.25 0.40 0.25
Age -2.35 -14.24 9.53 6.06 0.70
Age^2 -8.66 -20.49 3.17 6.04 0.15
Mixed or multiple ethnic origins 0.32 -0.40 1.04 0.37 0.38
Asian or Asian British -0.19 -1.36 0.98 0.60 0.75
African or African British -1.66 -3.52 0.20 0.95 0.08
Other ethnicity 0.05 -1.03 1.13 0.55 0.93
Key worker 0.16 -0.06 0.38 0.11 0.15
Time difference: Lockdown to baseline -0.01 -0.07 0.06 0.03 0.82
n R2 adjust. R2 F p value df
12006 0.00 0.00 3.23 0.004 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.21 1.40 3.03 0.42 1.16e-07
gad.sum_score_prepan 0.55 0.54 0.57 0.01 0.00e+00
Anxiety disorders 0.59 -0.30 1.49 0.46 0.19
Eating disorders 0.60 -1.12 2.33 0.88 0.49
OCDs 1.49 0.29 2.69 0.61 0.02
PTSD 1.06 -0.32 2.43 0.70 0.13
Depressive disorders 1.43 0.61 2.24 0.42 6.08e-04
Bipolar disorders 1.73 0.86 2.61 0.45 1.03e-04
n R2 adjust. R2 F p value df
12006 0.32 0.32 823.32 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.98 2.38 3.58 0.30 1.34e-22
gad.sum_score_prepan 0.52 0.50 0.53 0.01 0.00e+00
Depressive and anxiety disorder 0.83 0.23 1.42 0.30 0.006
Only depressive disorder -0.24 -0.88 0.40 0.33 0.47
Only anxiety disorder 0.11 -0.56 0.78 0.34 0.76
Eating disorders 0.73 0.44 1.02 0.15 6.17e-07
OCDs 0.61 0.34 0.88 0.14 1.08e-05
Psychotic and bipolar disorder -0.53 -1.31 0.26 0.40 0.19
Only psychotic disorder 0.39 -0.27 1.05 0.34 0.24
Only bipolar disorder 0.17 -0.23 0.56 0.20 0.41
PTSD 0.75 0.50 1.01 0.13 5.96e-09
ASD 0.90 0.38 1.42 0.27 7.08e-04
ADHD -0.13 -0.84 0.59 0.36 0.73
Personality disorder 0.92 0.56 1.27 0.18 3.95e-07
n R2 adjust. R2 F p value df
12028 0.00 0.00 8.99 7.92e-10 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.30 1.35 3.25 0.48 1.99e-06
gad.sum_score_prepan 0.52 0.51 0.54 0.01 0.00e+00
Anxiety disorders 0.56 -0.33 1.46 0.46 0.21
Eating disorders 0.48 -1.23 2.19 0.87 0.58
OCDs 1.26 0.07 2.46 0.61 0.04
PTSD 1.32 -0.06 2.69 0.70 0.06
Depressive disorders 1.53 0.72 2.35 0.42 2.34e-04
Bipolar disorders 1.97 1.10 2.85 0.45 1.01e-05
Female 0.55 0.32 0.77 0.12 2.33e-06
Non-binary/Self-defined 0.86 0.20 1.51 0.34 0.01
age_category_collapsed_reordered16-18 0.92 0.35 1.49 0.29 0.002
19-25 years 0.72 0.42 1.03 0.15 3.08e-06
36-45 years -0.15 -0.42 0.11 0.13 0.25
46-55 years -0.51 -0.77 -0.26 0.13 8.84e-05
56-65 years -1.03 -1.32 -0.74 0.15 3.46e-12
66-70 years -2.00 -2.51 -1.49 0.26 1.22e-14
71-75 years -2.33 -2.99 -1.67 0.34 5.72e-12
76+ years -2.01 -3.23 -0.79 0.62 0.001
Mixed or multiple ethnic origins 0.03 -0.57 0.62 0.30 0.93
Asian or Asian British -0.27 -1.24 0.71 0.50 0.59
African or African British -0.43 -1.98 1.12 0.79 0.59
Other ethnicity 0.40 -0.49 1.29 0.45 0.38
Key worker -0.34 -0.52 -0.16 0.09 1.96e-04
Time difference: Lockdown to baseline 0.01 -0.04 0.06 0.03 0.70
n R2 adjust. R2 F p value df
12028 0.00 0.00 8.99 7.92e-10 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.07 2.30 3.85 0.40 1.02e-14
gad.sum_score_prepan 0.49 0.48 0.51 0.01 0.00e+00
Depressive and anxiety disorder 0.92 0.33 1.51 0.30 0.002
Only depressive disorder 0.01 -0.63 0.65 0.33 0.97
Only anxiety disorder 0.07 -0.60 0.74 0.34 0.84
Eating disorders 0.61 0.32 0.89 0.15 3.68e-05
OCDs 0.53 0.26 0.80 0.14 1.23e-04
Psychotic and bipolar disorder -0.26 -1.04 0.52 0.40 0.52
Only psychotic disorder 0.45 -0.20 1.10 0.33 0.18
Only bipolar disorder 0.32 -0.07 0.71 0.20 0.11
PTSD 0.82 0.56 1.07 0.13 2.73e-10
ASD 0.71 0.18 1.23 0.27 0.009
ADHD -0.22 -0.93 0.49 0.36 0.55
Personality disorder 0.79 0.44 1.15 0.18 1.09e-05
Female 0.40 0.16 0.64 0.12 9.70e-04
Non-binary/Self-defined 0.41 -0.27 1.09 0.35 0.23
age_category_collapsed_reordered16-18 1.04 0.47 1.60 0.29 3.68e-04
19-25 years 0.75 0.44 1.06 0.16 2.44e-06
36-45 years -0.15 -0.42 0.12 0.14 0.29
46-55 years -0.43 -0.70 -0.17 0.14 0.001
56-65 years -0.87 -1.17 -0.56 0.15 1.82e-08
66-70 years -1.85 -2.37 -1.32 0.27 7.69e-12
71-75 years -2.04 -2.73 -1.34 0.36 1.01e-08
76+ years -1.53 -2.87 -0.18 0.69 0.03
Mixed or multiple ethnic origins 0.06 -0.56 0.68 0.32 0.86
Asian or Asian British -0.03 -1.03 0.97 0.51 0.95
African or African British -0.68 -2.27 0.92 0.81 0.41
Other ethnicity 0.46 -0.47 1.39 0.47 0.33
Key worker -0.22 -0.41 -0.04 0.09 0.02
Time difference: Lockdown to baseline 0.00 -0.05 0.06 0.03 0.89
n R2 adjust. R2 F p value df
12028 0.00 0.00 8.99 7.92e-10 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.04 1.11 2.97 0.47 1.80e-05
gad.sum_score_prepan 0.52 0.51 0.54 0.01 0.00e+00
Anxiety disorders 0.54 -0.35 1.44 0.46 0.23
Eating disorders 0.47 -1.24 2.18 0.87 0.59
OCDs 1.27 0.08 2.47 0.61 0.04
PTSD 1.29 -0.09 2.66 0.70 0.07
Depressive disorders 1.50 0.69 2.32 0.42 3.06e-04
Bipolar disorders 1.94 1.06 2.81 0.45 1.42e-05
Female 0.53 0.30 0.76 0.12 4.52e-06
Non-binary/Self-defined 0.85 0.19 1.50 0.34 0.01
Age -74.57 -84.53 -64.61 5.08 2.57e-48
Age^2 -10.41 -20.12 -0.71 4.95 0.04
Mixed or multiple ethnic origins 0.00 -0.59 0.60 0.30 0.99
Asian or Asian British -0.26 -1.23 0.72 0.50 0.60
African or African British -0.43 -1.98 1.12 0.79 0.59
Other ethnicity 0.41 -0.48 1.30 0.45 0.37
Key worker -0.35 -0.53 -0.17 0.09 1.08e-04
Time difference: Lockdown to baseline 0.01 -0.04 0.06 0.03 0.67
n R2 adjust. R2 F p value df
12028 0.00 0.00 8.99 7.92e-10 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.87 2.12 3.62 0.38 6.88e-14
gad.sum_score_prepan 0.49 0.48 0.51 0.01 0.00e+00
Depressive and anxiety disorder 0.88 0.29 1.47 0.30 0.004
Only depressive disorder -0.01 -0.65 0.63 0.33 0.99
Only anxiety disorder 0.04 -0.63 0.71 0.34 0.91
Eating disorders 0.61 0.32 0.90 0.15 3.18e-05
OCDs 0.52 0.25 0.79 0.14 1.45e-04
Psychotic and bipolar disorder -0.24 -1.03 0.54 0.40 0.54
Only psychotic disorder 0.47 -0.18 1.12 0.33 0.16
Only bipolar disorder 0.32 -0.07 0.71 0.20 0.11
PTSD 0.83 0.57 1.08 0.13 1.83e-10
ASD 0.73 0.20 1.25 0.27 0.007
ADHD -0.25 -0.96 0.46 0.36 0.49
Personality disorder 0.75 0.40 1.10 0.18 3.18e-05
Female 0.39 0.15 0.63 0.12 0.001
Non-binary/Self-defined 0.40 -0.28 1.08 0.35 0.25
Age -68.91 -79.32 -58.50 5.31 3.00e-38
Age^2 -6.01 -16.16 4.15 5.18 0.25
Mixed or multiple ethnic origins 0.04 -0.58 0.66 0.32 0.90
Asian or Asian British -0.03 -1.03 0.97 0.51 0.95
African or African British -0.68 -2.28 0.92 0.81 0.40
Other ethnicity 0.46 -0.47 1.38 0.47 0.34
Key worker -0.23 -0.42 -0.05 0.09 0.01
Time difference: Lockdown to baseline 0.01 -0.05 0.06 0.03 0.86
n R2 adjust. R2 F p value df
12028 0.00 0.00 8.99 7.92e-10 6

GAD prepan: sensitivity

Regression: Absolute scores

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline #### Subset of participants 3 months prior to pandemic

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.34 -0.05 4.72 1.21 0.05
gad.sum_score_prepan 0.54 0.49 0.60 0.03 1.22e-63
Depressive and anxiety disorder 0.73 -0.92 2.38 0.84 0.39
Only depressive disorder -0.27 -2.04 1.51 0.90 0.77
Only anxiety disorder 0.11 -1.87 2.08 1.01 0.92
Eating disorders 0.88 -0.16 1.92 0.53 0.10
OCDs 0.03 -1.02 1.08 0.54 0.96
Psychotic and bipolar disorder -0.81 -3.33 1.71 1.28 0.53
Only psychotic disorder 0.37 -2.23 2.96 1.32 0.78
Only bipolar disorder -0.53 -2.17 1.11 0.84 0.53
PTSD 2.02 1.06 2.98 0.49 3.84e-05
ASD 1.10 -0.73 2.92 0.93 0.24
ADHD -0.19 -2.74 2.36 1.30 0.88
Personality disorder -0.51 -1.83 0.80 0.67 0.44
Female 0.64 -0.22 1.49 0.44 0.14
Non-binary/Self-defined -0.79 -3.92 2.33 1.59 0.62
age_category_collapsed_reordered16-18 1.36 -0.51 3.22 0.95 0.15
19-25 years 0.83 -0.44 2.10 0.64 0.20
36-45 years -0.05 -1.11 1.01 0.54 0.93
46-55 years -0.36 -1.42 0.70 0.54 0.50
56-65 years -0.27 -1.38 0.84 0.56 0.63
66-70 years -1.36 -3.33 0.61 1.00 0.17
71-75 years -0.92 -3.73 1.88 1.43 0.52
76+ years 0.39 -3.07 3.86 1.76 0.82
Mixed or multiple ethnic origins -0.49 -2.75 1.78 1.15 0.67
Asian or Asian British -0.18 -3.79 3.43 1.84 0.92
African or African British -3.14 -7.41 1.13 2.18 0.15
Other ethnicity 0.61 -3.62 4.84 2.16 0.78
Key worker 0.25 -0.48 0.97 0.37 0.50
Time difference: Lockdown to baseline -0.01 -0.18 0.16 0.09 0.89
n R2 adjust. R2 F p value df
831 0.01 0.00 1.47 0.18 6

Subset of participants 6 months prior to pandemic

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.12 0.46 3.79 0.85 0.01
gad.sum_score_prepan 0.54 0.50 0.58 0.02 1.01e-128
Depressive and anxiety disorder 0.82 -0.26 1.90 0.55 0.14
Only depressive disorder -0.20 -1.39 0.98 0.60 0.74
Only anxiety disorder 0.31 -0.99 1.62 0.66 0.64
Eating disorders 0.55 -0.20 1.30 0.38 0.15
OCDs 0.58 -0.12 1.28 0.36 0.11
Psychotic and bipolar disorder -0.47 -2.50 1.56 1.03 0.65
Only psychotic disorder 0.47 -1.08 2.02 0.79 0.55
Only bipolar disorder -0.10 -1.15 0.96 0.54 0.85
PTSD 1.73 1.07 2.40 0.34 4.05e-07
ASD 0.33 -1.04 1.69 0.70 0.64
ADHD -0.61 -2.22 1.00 0.82 0.46
Personality disorder 0.51 -0.40 1.43 0.47 0.27
Female 0.58 -0.02 1.18 0.31 0.06
Non-binary/Self-defined 0.94 -0.98 2.86 0.98 0.34
age_category_collapsed_reordered16-18 1.26 0.11 2.41 0.59 0.03
19-25 years 0.90 0.02 1.78 0.45 0.04
36-45 years -0.28 -1.03 0.47 0.38 0.47
46-55 years -0.59 -1.33 0.15 0.38 0.12
56-65 years -0.46 -1.26 0.33 0.40 0.25
66-70 years -1.02 -2.36 0.31 0.68 0.13
71-75 years -1.42 -3.01 0.17 0.81 0.08
76+ years 0.41 -2.05 2.87 1.25 0.74
Mixed or multiple ethnic origins 0.71 -0.84 2.27 0.79 0.37
Asian or Asian British -0.71 -2.78 1.36 1.06 0.50
African or African British -3.09 -6.58 0.40 1.78 0.08
Other ethnicity -0.37 -2.84 2.10 1.26 0.77
Key worker 0.06 -0.43 0.56 0.25 0.80
Time difference: Lockdown to baseline 0.00 -0.14 0.13 0.07 0.95
n R2 adjust. R2 F p value df
1637 0.00 0.00 1.21 0.30 6

Subset of participants 9 months prior to pandemic

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.70 1.39 4.00 0.67 5.16e-05
gad.sum_score_prepan 0.53 0.50 0.57 0.02 6.85e-209
Depressive and anxiety disorder 1.03 0.17 1.88 0.44 0.02
Only depressive disorder 0.22 -0.71 1.14 0.47 0.65
Only anxiety disorder 0.49 -0.54 1.53 0.53 0.35
Eating disorders 0.92 0.34 1.50 0.29 0.002
OCDs 0.57 0.03 1.11 0.28 0.04
Psychotic and bipolar disorder -0.66 -2.16 0.85 0.77 0.39
Only psychotic disorder 0.74 -0.47 1.94 0.62 0.23
Only bipolar disorder 0.22 -0.59 1.02 0.41 0.60
PTSD 1.36 0.85 1.87 0.26 1.50e-07
ASD 0.07 -1.00 1.13 0.54 0.90
ADHD -0.63 -1.94 0.68 0.67 0.35
Personality disorder 0.77 0.07 1.48 0.36 0.03
Female 0.42 -0.04 0.87 0.23 0.07
Non-binary/Self-defined 1.00 -0.42 2.41 0.72 0.17
age_category_collapsed_reordered16-18 1.12 0.13 2.12 0.51 0.03
19-25 years 0.48 -0.21 1.17 0.35 0.17
36-45 years -0.24 -0.81 0.34 0.29 0.42
46-55 years -0.53 -1.08 0.02 0.28 0.06
56-65 years -0.80 -1.39 -0.20 0.30 0.009
66-70 years -1.23 -2.21 -0.25 0.50 0.01
71-75 years -1.05 -2.23 0.14 0.60 0.08
76+ years -0.61 -2.65 1.43 1.04 0.56
Mixed or multiple ethnic origins 0.84 -0.47 2.15 0.67 0.21
Asian or Asian British -0.16 -1.77 1.46 0.83 0.85
African or African British -0.23 -2.97 2.51 1.40 0.87
Other ethnicity 0.04 -1.60 1.68 0.84 0.96
Key worker -0.05 -0.43 0.32 0.19 0.78
Time difference: Lockdown to baseline -0.06 -0.16 0.05 0.05 0.28
n R2 adjust. R2 F p value df
2715 0.01 0.00 2.97 0.007 6

##KT

GAD retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.58 2.44 2.72 0.07 1.55e-271
Anxiety disorders 0.84 0.54 1.15 0.16 6.90e-08
Eating disorders 0.40 -0.52 1.31 0.47 0.40
OCDs 1.16 0.40 1.92 0.39 0.003
PTSD 1.37 0.63 2.10 0.38 2.69e-04
Depressive disorders 0.87 0.70 1.04 0.09 2.08e-24
Bipolar disorders 0.83 0.46 1.19 0.19 9.14e-06
n R2 adjust. R2 F p value df
19545 0.01 0.01 18.93 4.26e-22 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.58 2.45 2.71 0.07 2.17e-303
Depressive and anxiety disorder 0.85 0.68 1.03 0.09 4.94e-21
Only depressive disorder 0.25 0.01 0.48 0.12 0.04
Only anxiety disorder 0.86 0.58 1.15 0.14 2.26e-09
Eating disorders 0.49 0.22 0.76 0.14 4.28e-04
OCDs 0.05 -0.21 0.31 0.13 0.72
Psychotic and bipolar disorder -0.20 -0.96 0.56 0.39 0.61
Only psychotic disorder -0.28 -0.94 0.38 0.34 0.41
Only bipolar disorder -0.21 -0.62 0.19 0.21 0.30
PTSD 0.41 0.17 0.66 0.12 8.72e-04
ASD 0.36 -0.12 0.83 0.24 0.14
ADHD 0.01 -0.63 0.64 0.32 0.99
Personality disorder 0.29 -0.06 0.64 0.18 0.11
n R2 adjust. R2 F p value df
19545 0.01 0.01 18.93 4.26e-22 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.19 3.83 4.55 0.18 1.28e-112
Anxiety disorders 0.55 0.23 0.87 0.16 7.12e-04
Eating disorders 0.00 -0.93 0.94 0.47 0.99
OCDs 0.57 -0.21 1.35 0.40 0.15
PTSD 1.11 0.35 1.86 0.39 0.004
Depressive disorders 0.62 0.43 0.80 0.09 5.33e-11
Bipolar disorders 0.61 0.24 0.99 0.19 0.001
Female 0.76 0.56 0.95 0.10 1.32e-14
Non-binary/Self-defined -0.15 -0.80 0.49 0.33 0.64
age_category_collapsed_reordered16-18 -0.43 -0.84 -0.01 0.21 0.04
19-25 years 0.73 0.44 1.02 0.15 6.32e-07
36-45 years -0.50 -0.75 -0.25 0.13 8.62e-05
46-55 years -0.68 -0.91 -0.45 0.12 1.23e-08
56-65 years -0.88 -1.11 -0.64 0.12 4.16e-13
66-70 years -1.15 -1.50 -0.81 0.18 5.82e-11
71-75 years -1.60 -2.02 -1.18 0.22 1.39e-13
76+ years -1.89 -2.63 -1.16 0.38 4.66e-07
Mixed or multiple ethnic origins -0.63 -1.16 -0.11 0.27 0.02
Asian or Asian British -0.43 -1.13 0.27 0.36 0.23
African or African British -0.83 -2.09 0.44 0.65 0.20
Other ethnicity -0.08 -0.97 0.80 0.45 0.85
Time difference: Lockdown to baseline -0.23 -0.26 -0.19 0.02 1.09e-35
n R2 adjust. R2 F p value df
19545 0.01 0.01 18.93 4.26e-22 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.94 3.57 4.31 0.19 2.33e-95
Depressive and anxiety disorder 0.65 0.45 0.84 0.10 5.79e-11
Only depressive disorder 0.25 0.00 0.51 0.13 0.05
Only anxiety disorder 0.63 0.33 0.93 0.15 3.24e-05
Eating disorders 0.28 0.01 0.56 0.14 0.04
OCDs -0.09 -0.36 0.17 0.14 0.49
Psychotic and bipolar disorder 0.10 -0.67 0.86 0.39 0.80
Only psychotic disorder -0.05 -0.71 0.62 0.34 0.89
Only bipolar disorder -0.11 -0.52 0.30 0.21 0.60
PTSD 0.43 0.18 0.68 0.13 6.91e-04
ASD 0.36 -0.13 0.85 0.25 0.15
ADHD -0.06 -0.70 0.58 0.33 0.85
Personality disorder 0.18 -0.18 0.53 0.18 0.33
Female 0.73 0.53 0.93 0.10 3.89e-13
Non-binary/Self-defined -0.32 -0.98 0.34 0.34 0.35
age_category_collapsed_reordered16-18 -0.20 -0.62 0.22 0.21 0.35
19-25 years 0.74 0.45 1.03 0.15 7.34e-07
36-45 years -0.50 -0.75 -0.24 0.13 1.23e-04
46-55 years -0.67 -0.91 -0.43 0.12 4.76e-08
56-65 years -0.72 -0.97 -0.47 0.13 1.06e-08
66-70 years -0.87 -1.23 -0.51 0.18 2.39e-06
71-75 years -1.28 -1.72 -0.84 0.22 1.08e-08
76+ years -1.58 -2.33 -0.84 0.38 3.15e-05
Mixed or multiple ethnic origins -0.57 -1.10 -0.04 0.27 0.04
Asian or Asian British -0.22 -0.91 0.46 0.35 0.53
African or African British -1.10 -2.36 0.17 0.65 0.09
Other ethnicity 0.08 -0.82 0.98 0.46 0.86
Key worker 0.31 0.15 0.47 0.08 1.21e-04
Time difference: Lockdown to baseline -0.22 -0.26 -0.19 0.02 6.21e-34
n R2 adjust. R2 F p value df
19545 0.01 0.01 18.93 4.26e-22 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.97 1.54 2.39 0.22 1.63e-19
Anxiety disorders 0.53 0.12 0.94 0.21 0.01
Eating disorders 0.37 -0.79 1.53 0.59 0.53
OCDs 0.39 -0.63 1.40 0.52 0.45
PTSD 1.32 0.23 2.42 0.56 0.02
Depressive disorders 0.92 0.69 1.15 0.12 4.50e-15
Bipolar disorders 0.99 0.56 1.42 0.22 7.14e-06
Female 0.61 0.39 0.83 0.11 4.12e-08
Non-binary/Self-defined -0.49 -1.21 0.22 0.37 0.18
Age -96.47 -111.58 -81.36 7.71 1.00e-35
Age^2 8.51 -5.53 22.55 7.16 0.23
Mixed or multiple ethnic origins -0.69 -1.31 -0.08 0.31 0.03
Asian or Asian British -0.20 -1.10 0.71 0.46 0.67
African or African British -0.76 -2.25 0.72 0.76 0.32
Other ethnicity 0.07 -1.01 1.14 0.55 0.90
Time difference: Lockdown to baseline -0.06 -0.11 -0.02 0.02 0.010
n R2 adjust. R2 F p value df
14004 0.01 0.01 29.70 1.42e-35 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.87 1.44 2.31 0.22 2.58e-17
Depressive and anxiety disorder 0.94 0.71 1.18 0.12 6.86e-15
Only depressive disorder 0.48 0.17 0.79 0.16 0.002
Only anxiety disorder 0.60 0.22 0.98 0.19 0.002
Eating disorders 0.26 -0.05 0.58 0.16 0.10
OCDs -0.27 -0.57 0.03 0.15 0.08
Psychotic and bipolar disorder 0.33 -0.57 1.24 0.46 0.47
Only psychotic disorder -0.06 -0.81 0.68 0.38 0.87
Only bipolar disorder -0.11 -0.56 0.33 0.23 0.62
PTSD 0.58 0.30 0.86 0.14 5.59e-05
ASD 0.15 -0.44 0.73 0.30 0.62
ADHD 0.09 -0.70 0.88 0.40 0.82
Personality disorder 0.31 -0.09 0.71 0.20 0.13
Female 0.57 0.35 0.79 0.11 5.57e-07
Non-binary/Self-defined -0.73 -1.47 0.01 0.38 0.05
Age -82.49 -98.45 -66.52 8.14 5.15e-24
Age^2 18.68 4.05 33.31 7.46 0.01
Mixed or multiple ethnic origins -0.62 -1.24 0.01 0.32 0.05
Asian or Asian British -0.10 -0.99 0.79 0.45 0.82
African or African British -1.01 -2.51 0.49 0.77 0.19
Other ethnicity 0.11 -0.98 1.19 0.55 0.85
Key worker 0.33 0.15 0.51 0.09 4.48e-04
Time difference: Lockdown to baseline -0.07 -0.12 -0.02 0.03 0.009
n R2 adjust. R2 F p value df
14004 0.01 0.01 29.70 1.42e-35 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.38 1.31 1.46 0.04 1.10e-275
gad.sum_score_retro 0.77 0.76 0.78 0.01 0.00e+00
Anxiety disorders 2.13 1.93 2.34 0.11 9.92e-91
Eating disorders 1.88 1.22 2.54 0.34 2.07e-08
OCDs 2.84 2.31 3.38 0.27 2.25e-25
PTSD 2.67 2.15 3.18 0.26 3.62e-24
Depressive disorders 2.65 2.54 2.76 0.06 0.00e+00
Bipolar disorders 3.13 2.86 3.40 0.14 1.12e-115
n R2 adjust. R2 F p value df
30902 0.53 0.53 4928.90 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.54 1.46 1.61 0.04 0.00e+00
gad.sum_score_retro 0.72 0.71 0.73 0.01 0.00e+00
Depressive and anxiety disorder 2.92 2.79 3.04 0.06 0.00e+00
Only depressive disorder 1.17 1.02 1.32 0.08 1.47e-54
Only anxiety disorder 2.24 2.05 2.43 0.10 5.26e-117
Eating disorders 0.79 0.59 0.98 0.10 8.05e-15
OCDs 0.59 0.40 0.79 0.10 1.16e-09
Psychotic and bipolar disorder 0.07 -0.47 0.61 0.28 0.80
Only psychotic disorder -0.02 -0.49 0.45 0.24 0.93
Only bipolar disorder 0.14 -0.15 0.44 0.15 0.34
PTSD 0.72 0.54 0.89 0.09 1.42e-15
ASD 0.89 0.55 1.24 0.18 4.01e-07
ADHD 0.36 -0.10 0.81 0.23 0.12
Personality disorder 0.68 0.43 0.93 0.13 1.36e-07
n R2 adjust. R2 F p value df
30973 0.25 0.25 1678.24 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.72 3.47 3.97 0.13 1.43e-189
gad.sum_score_retro 0.70 0.69 0.71 0.01 0.00e+00
Anxiety disorders 1.63 1.41 1.85 0.11 1.51e-48
Eating disorders 1.15 0.48 1.82 0.34 8.10e-04
OCDs 1.79 1.25 2.34 0.28 1.41e-10
PTSD 2.28 1.75 2.82 0.27 7.21e-17
Depressive disorders 2.20 2.08 2.32 0.06 4.68e-271
Bipolar disorders 2.78 2.50 3.05 0.14 2.82e-87
Female 0.82 0.70 0.94 0.06 1.54e-43
Non-binary/Self-defined 0.42 -0.04 0.88 0.24 0.07
age_category_collapsed_reordered16-18 0.72 0.41 1.03 0.16 4.70e-06
19-25 years 0.93 0.72 1.15 0.11 4.29e-18
36-45 years -0.56 -0.74 -0.39 0.09 5.14e-10
46-55 years -0.95 -1.12 -0.79 0.08 9.45e-30
56-65 years -1.45 -1.62 -1.29 0.08 2.87e-66
66-70 years -2.03 -2.24 -1.82 0.11 6.47e-77
71-75 years -2.24 -2.48 -2.00 0.12 3.94e-72
76+ years -2.32 -2.68 -1.95 0.19 4.16e-35
Mixed or multiple ethnic origins -0.33 -0.70 0.04 0.19 0.08
Asian or Asian British -0.46 -0.90 -0.01 0.23 0.05
African or African British -0.49 -1.31 0.33 0.42 0.24
Other ethnicity 0.18 -0.46 0.82 0.33 0.58
Key worker -0.01 -0.12 0.09 0.05 0.83
Time difference: Lockdown to baseline -0.21 -0.23 -0.19 0.01 3.50e-64
n R2 adjust. R2 F p value df
30973 0.25 0.25 1678.24 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.66 3.41 3.90 0.12 6.75e-186
gad.sum_score_retro 0.66 0.65 0.67 0.01 0.00e+00
Depressive and anxiety disorder 2.49 2.36 2.63 0.07 9.91e-287
Only depressive disorder 1.04 0.88 1.19 0.08 7.88e-38
Only anxiety disorder 1.79 1.58 1.99 0.10 2.06e-67
Eating disorders 0.49 0.29 0.69 0.10 1.73e-06
OCDs 0.43 0.23 0.62 0.10 1.48e-05
Psychotic and bipolar disorder 0.35 -0.19 0.90 0.28 0.21
Only psychotic disorder 0.21 -0.26 0.68 0.24 0.39
Only bipolar disorder 0.32 0.02 0.62 0.15 0.03
PTSD 0.78 0.60 0.96 0.09 1.65e-17
ASD 0.64 0.29 0.99 0.18 3.79e-04
ADHD 0.11 -0.35 0.57 0.24 0.64
Personality disorder 0.61 0.36 0.87 0.13 2.64e-06
Female 0.80 0.68 0.91 0.06 1.33e-41
Non-binary/Self-defined 0.09 -0.37 0.55 0.24 0.71
age_category_collapsed_reordered16-18 1.04 0.74 1.34 0.15 1.31e-11
19-25 years 0.94 0.73 1.15 0.11 3.31e-18
36-45 years -0.50 -0.68 -0.33 0.09 3.25e-08
46-55 years -0.82 -0.99 -0.65 0.08 4.11e-22
56-65 years -1.20 -1.37 -1.04 0.08 3.04e-45
66-70 years -1.73 -1.95 -1.52 0.11 2.01e-56
71-75 years -1.93 -2.18 -1.69 0.12 2.64e-54
76+ years -1.99 -2.35 -1.63 0.18 3.21e-27
Mixed or multiple ethnic origins -0.24 -0.61 0.12 0.19 0.19
Asian or Asian British -0.13 -0.57 0.30 0.22 0.55
African or African British -0.61 -1.42 0.19 0.41 0.13
Other ethnicity 0.39 -0.26 1.04 0.33 0.24
Key worker 0.05 -0.05 0.16 0.05 0.32
Time difference: Lockdown to baseline -0.22 -0.24 -0.19 0.01 7.46e-68
n R2 adjust. R2 F p value df
30973 0.25 0.25 1678.24 0.00e+00 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.25 0.99 1.50 0.13 9.13e-22
gad.sum_score_retro 0.69 0.68 0.70 0.01 0.00e+00
Anxiety disorders 1.51 1.25 1.76 0.13 6.87e-31
Eating disorders 1.32 0.55 2.08 0.39 7.56e-04
OCDs 1.97 1.30 2.64 0.34 9.72e-09
PTSD 2.37 1.66 3.08 0.36 5.47e-11
Depressive disorders 2.45 2.31 2.58 0.07 5.43e-264
Bipolar disorders 3.06 2.77 3.35 0.15 1.54e-92
Female 0.60 0.48 0.72 0.06 8.58e-22
Non-binary/Self-defined 0.21 -0.28 0.70 0.25 0.41
Age -134.10 -143.52 -124.67 4.81 4.59e-168
Age^2 12.68 4.33 21.03 4.26 0.003
Mixed or multiple ethnic origins -0.42 -0.82 -0.02 0.20 0.04
Asian or Asian British -0.17 -0.70 0.35 0.27 0.52
African or African British -0.33 -1.19 0.54 0.44 0.46
Other ethnicity 0.38 -0.36 1.12 0.38 0.32
Key worker -0.03 -0.14 0.09 0.06 0.64
Time difference: Lockdown to baseline -0.03 -0.06 0.01 0.02 0.11
n R2 adjust. R2 F p value df
23658 0.30 0.30 1725.06 0.00e+00 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.25 1.00 1.50 0.13 2.19e-22
gad.sum_score_retro 0.65 0.63 0.66 0.01 0.00e+00
Depressive and anxiety disorder 2.79 2.65 2.94 0.08 3.50e-290
Only depressive disorder 1.19 1.01 1.36 0.09 7.37e-40
Only anxiety disorder 1.76 1.52 1.99 0.12 1.02e-48
Eating disorders 0.56 0.35 0.78 0.11 3.55e-07
OCDs 0.33 0.13 0.54 0.11 0.002
Psychotic and bipolar disorder 0.45 -0.17 1.07 0.32 0.16
Only psychotic disorder 0.26 -0.24 0.77 0.26 0.31
Only bipolar disorder 0.32 0.01 0.63 0.16 0.04
PTSD 0.91 0.71 1.10 0.10 4.79e-20
ASD 0.52 0.11 0.92 0.20 0.01
ADHD 0.18 -0.36 0.71 0.27 0.52
Personality disorder 0.67 0.40 0.94 0.14 1.45e-06
Female 0.54 0.42 0.66 0.06 1.88e-18
Non-binary/Self-defined -0.18 -0.67 0.31 0.25 0.48
Age -116.86 -126.36 -107.36 4.85 1.09e-126
Age^2 14.87 6.62 23.12 4.21 4.13e-04
Mixed or multiple ethnic origins -0.34 -0.74 0.05 0.20 0.09
Asian or Asian British 0.04 -0.47 0.55 0.26 0.88
African or African British -0.43 -1.27 0.42 0.43 0.32
Other ethnicity 0.45 -0.30 1.20 0.38 0.24
Key worker 0.06 -0.05 0.18 0.06 0.27
Time difference: Lockdown to baseline -0.02 -0.05 0.01 0.02 0.17
n R2 adjust. R2 F p value df
23658 0.30 0.30 1725.06 0.00e+00 6

GAD retro: sensitivity

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.16 1.01 3.31 0.59 2.36e-04
Anxiety disorders 1.11 -0.15 2.37 0.64 0.08
Eating disorders 1.88 -0.47 4.22 1.19 0.12
OCDs 1.28 -0.42 2.97 0.86 0.14
PTSD 2.04 0.19 3.90 0.95 0.03
Depressive disorders 1.15 -0.01 2.31 0.59 0.05
Bipolar disorders 1.01 -0.22 2.24 0.63 0.11
n R2 adjust. R2 F p value df
8623 0.00 0.00 1.03 0.40 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.55 1.72 3.38 0.42 1.97e-09
Depressive and anxiety disorder 0.73 -0.11 1.57 0.43 0.09
Only depressive disorder 0.15 -0.76 1.07 0.47 0.74
Only anxiety disorder 0.84 -0.11 1.78 0.48 0.08
Eating disorders 0.55 0.16 0.93 0.20 0.006
OCDs -0.21 -0.57 0.15 0.18 0.25
Psychotic and bipolar disorder -0.30 -1.39 0.79 0.56 0.59
Only psychotic disorder -0.16 -1.07 0.74 0.46 0.73
Only bipolar disorder -0.29 -0.83 0.24 0.27 0.28
PTSD 0.39 0.06 0.73 0.17 0.02
ASD 0.22 -0.49 0.92 0.36 0.55
ADHD 0.12 -0.86 1.09 0.50 0.81
Personality disorder 0.42 -0.06 0.90 0.24 0.09
n R2 adjust. R2 F p value df
8623 0.00 0.00 1.03 0.40 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.49 1.17 3.81 0.67 2.08e-04
Anxiety disorders 1.00 -0.25 2.24 0.64 0.12
Eating disorders 1.59 -0.73 3.92 1.19 0.18
OCDs 0.99 -0.68 2.67 0.86 0.25
PTSD 2.15 0.31 3.99 0.94 0.02
Depressive disorders 1.20 0.05 2.35 0.59 0.04
Bipolar disorders 1.17 -0.06 2.39 0.63 0.06
Female 0.62 0.30 0.94 0.16 1.54e-04
Non-binary/Self-defined -0.54 -1.42 0.34 0.45 0.23
age_category_collapsed_reordered16-18 -0.25 -1.00 0.50 0.38 0.52
19-25 years 0.75 0.36 1.15 0.20 1.85e-04
36-45 years -0.45 -0.80 -0.10 0.18 0.01
46-55 years -0.66 -1.00 -0.31 0.18 1.86e-04
56-65 years -1.21 -1.60 -0.81 0.20 1.85e-09
66-70 years -1.48 -2.22 -0.74 0.38 8.68e-05
71-75 years -2.21 -3.18 -1.23 0.50 9.89e-06
76+ years -2.77 -4.81 -0.73 1.04 0.008
Mixed or multiple ethnic origins -0.83 -1.63 -0.03 0.41 0.04
Asian or Asian British 0.14 -1.17 1.46 0.67 0.83
African or African British -1.43 -3.46 0.60 1.03 0.17
Other ethnicity -0.05 -1.27 1.18 0.63 0.94
Time difference: Lockdown to baseline -0.06 -0.14 0.01 0.04 0.08
n R2 adjust. R2 F p value df
8623 0.00 0.00 1.03 0.40 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.81 1.73 3.89 0.55 3.43e-07
Depressive and anxiety disorder 0.70 -0.14 1.55 0.43 0.10
Only depressive disorder 0.37 -0.55 1.28 0.47 0.43
Only anxiety disorder 0.67 -0.28 1.61 0.48 0.17
Eating disorders 0.37 -0.02 0.76 0.20 0.06
OCDs -0.27 -0.63 0.09 0.18 0.15
Psychotic and bipolar disorder 0.05 -1.04 1.13 0.55 0.93
Only psychotic disorder 0.11 -0.80 1.02 0.46 0.81
Only bipolar disorder -0.16 -0.70 0.37 0.27 0.55
PTSD 0.46 0.12 0.80 0.17 0.008
ASD 0.25 -0.46 0.96 0.36 0.49
ADHD 0.21 -0.76 1.18 0.50 0.67
Personality disorder 0.29 -0.19 0.77 0.24 0.24
Female 0.59 0.25 0.93 0.17 6.96e-04
Non-binary/Self-defined -0.76 -1.68 0.15 0.47 0.10
age_category_collapsed_reordered16-18 -0.09 -0.86 0.67 0.39 0.81
19-25 years 0.74 0.33 1.15 0.21 3.67e-04
36-45 years -0.44 -0.81 -0.08 0.19 0.02
46-55 years -0.65 -1.01 -0.29 0.18 4.19e-04
56-65 years -1.05 -1.47 -0.64 0.21 6.61e-07
66-70 years -1.23 -2.01 -0.45 0.40 0.002
71-75 years -1.70 -2.74 -0.66 0.53 0.001
76+ years -2.61 -4.83 -0.39 1.13 0.02
Mixed or multiple ethnic origins -0.74 -1.57 0.09 0.42 0.08
Asian or Asian British 0.14 -1.20 1.49 0.69 0.83
African or African British -1.78 -3.86 0.30 1.06 0.09
Other ethnicity 0.01 -1.24 1.26 0.64 0.99
Key worker 0.36 0.11 0.61 0.13 0.005
Time difference: Lockdown to baseline -0.07 -0.15 0.00 0.04 0.06
n R2 adjust. R2 F p value df
8623 0.00 0.00 1.03 0.40 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.61 2.73 4.50 0.45 1.14e-15
gad.sum_score_retro 0.61 0.60 0.63 0.01 0.00e+00
Anxiety disorders 1.36 0.39 2.33 0.50 0.006
Eating disorders 2.45 0.57 4.33 0.96 0.01
OCDs 1.99 0.69 3.29 0.66 0.003
PTSD 2.44 0.96 3.92 0.75 0.001
Depressive disorders 1.61 0.73 2.50 0.45 3.45e-04
Bipolar disorders 1.94 0.99 2.89 0.48 6.17e-05
n R2 adjust. R2 F p value df
10363 0.29 0.29 611.78 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.35 3.72 4.99 0.32 3.91e-41
gad.sum_score_retro 0.57 0.55 0.59 0.01 0.00e+00
Depressive and anxiety disorder 1.07 0.44 1.70 0.32 8.85e-04
Only depressive disorder -0.43 -1.12 0.26 0.35 0.22
Only anxiety disorder 0.93 0.21 1.65 0.37 0.01
Eating disorders 0.81 0.51 1.11 0.15 1.71e-07
OCDs 0.47 0.18 0.75 0.15 0.001
Psychotic and bipolar disorder -0.24 -1.09 0.61 0.43 0.57
Only psychotic disorder 0.06 -0.65 0.76 0.36 0.87
Only bipolar disorder 0.03 -0.39 0.45 0.21 0.89
PTSD 0.71 0.45 0.98 0.14 1.61e-07
ASD 0.73 0.17 1.28 0.28 0.01
ADHD 0.27 -0.49 1.03 0.39 0.49
Personality disorder 0.95 0.58 1.32 0.19 5.63e-07
n R2 adjust. R2 F p value df
10376 0.01 0.01 10.21 2.72e-11 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.78 2.76 4.80 0.52 4.64e-13
gad.sum_score_retro 0.60 0.58 0.62 0.01 0.00e+00
Anxiety disorders 1.31 0.34 2.28 0.49 0.008
Eating disorders 2.31 0.45 4.18 0.95 0.01
OCDs 1.77 0.48 3.06 0.66 0.007
PTSD 2.72 1.25 4.19 0.75 2.85e-04
Depressive disorders 1.77 0.88 2.65 0.45 8.75e-05
Bipolar disorders 2.23 1.29 3.18 0.48 3.85e-06
Female 0.56 0.31 0.81 0.13 1.05e-05
Non-binary/Self-defined 0.28 -0.41 0.98 0.35 0.43
age_category_collapsed_reordered16-18 0.68 0.10 1.27 0.30 0.02
19-25 years 0.86 0.54 1.17 0.16 9.16e-08
36-45 years -0.40 -0.68 -0.12 0.14 0.005
46-55 years -0.62 -0.90 -0.35 0.14 7.70e-06
56-65 years -1.29 -1.60 -0.97 0.16 1.16e-15
66-70 years -1.98 -2.56 -1.39 0.30 3.43e-11
71-75 years -2.56 -3.34 -1.79 0.40 1.10e-10
76+ years -2.51 -4.12 -0.90 0.82 0.002
Mixed or multiple ethnic origins -0.53 -1.15 0.10 0.32 0.10
Asian or Asian British 0.06 -0.97 1.09 0.53 0.91
African or African British -0.32 -1.99 1.35 0.85 0.71
Other ethnicity 0.08 -0.88 1.03 0.49 0.87
Key worker -0.14 -0.33 0.06 0.10 0.16
Time difference: Lockdown to baseline -0.03 -0.09 0.02 0.03 0.26
n R2 adjust. R2 F p value df
10376 0.01 0.01 10.21 2.72e-11 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.57 3.74 5.40 0.42 3.31e-27
gad.sum_score_retro 0.56 0.54 0.58 0.01 0.00e+00
Depressive and anxiety disorder 1.12 0.49 1.76 0.32 5.20e-04
Only depressive disorder -0.14 -0.82 0.55 0.35 0.70
Only anxiety disorder 0.80 0.08 1.52 0.37 0.03
Eating disorders 0.65 0.35 0.95 0.15 2.74e-05
OCDs 0.39 0.11 0.67 0.14 0.007
Psychotic and bipolar disorder 0.02 -0.83 0.86 0.43 0.97
Only psychotic disorder 0.23 -0.47 0.93 0.36 0.52
Only bipolar disorder 0.18 -0.23 0.60 0.21 0.39
PTSD 0.80 0.53 1.07 0.14 4.01e-09
ASD 0.60 0.05 1.16 0.28 0.03
ADHD 0.24 -0.51 0.99 0.38 0.53
Personality disorder 0.82 0.45 1.19 0.19 1.53e-05
Female 0.43 0.16 0.69 0.13 0.001
Non-binary/Self-defined -0.19 -0.90 0.52 0.36 0.60
age_category_collapsed_reordered16-18 0.78 0.20 1.37 0.30 0.009
19-25 years 0.84 0.52 1.16 0.16 2.98e-07
36-45 years -0.36 -0.64 -0.07 0.15 0.01
46-55 years -0.54 -0.82 -0.25 0.14 2.10e-04
56-65 years -1.06 -1.39 -0.74 0.17 1.74e-10
66-70 years -1.75 -2.35 -1.14 0.31 1.38e-08
71-75 years -2.00 -2.82 -1.18 0.42 1.95e-06
76+ years -2.09 -3.79 -0.38 0.87 0.02
Mixed or multiple ethnic origins -0.49 -1.13 0.15 0.33 0.13
Asian or Asian British 0.19 -0.86 1.24 0.53 0.73
African or African British -0.52 -2.25 1.20 0.88 0.55
Other ethnicity 0.20 -0.78 1.18 0.50 0.69
Key worker -0.01 -0.21 0.19 0.10 0.93
Time difference: Lockdown to baseline -0.04 -0.10 0.02 0.03 0.22
n R2 adjust. R2 F p value df
10376 0.01 0.01 10.21 2.72e-11 6

PHQ baseline, not controlling for prior symptoms

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.31 3.20 3.42 0.05 0.00e+00
Anxiety disorders 3.59 3.31 3.88 0.15 1.16e-131
Eating disorders 3.92 3.00 4.84 0.47 6.66e-17
OCDs 5.90 5.15 6.64 0.38 5.02e-54
PTSD 5.21 4.48 5.94 0.37 1.54e-44
Depressive disorders 7.16 7.02 7.30 0.07 0.00e+00
Bipolar disorders 9.59 9.24 9.95 0.18 0.00e+00
n R2 adjust. R2 F p value df
32662 0.25 0.25 1854.75 0.00e+00 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.56 3.46 3.66 0.05 0.00e+00
Depressive and anxiety disorder 6.64 6.49 6.79 0.08 0.00e+00
Only depressive disorder 3.53 3.33 3.73 0.10 7.11e-257
Only anxiety disorder 3.22 2.97 3.48 0.13 5.24e-133
Eating disorders 2.18 1.92 2.45 0.14 4.24e-57
OCDs 2.04 1.78 2.30 0.13 4.62e-54
Psychotic and bipolar disorder 0.27 -0.46 1.00 0.37 0.47
Only psychotic disorder 0.80 0.17 1.42 0.32 0.01
Only bipolar disorder 1.31 0.91 1.70 0.20 6.16e-11
PTSD 2.05 1.81 2.29 0.12 1.16e-63
ASD 2.80 2.34 3.27 0.24 4.82e-32
ADHD 1.90 1.28 2.51 0.31 1.73e-09
Personality disorder 3.40 3.06 3.74 0.17 6.36e-84
n R2 adjust. R2 F p value df
32662 0.25 0.25 1854.75 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.23 5.90 6.55 0.17 9.38e-304
Anxiety disorders 2.16 1.87 2.45 0.15 1.17e-47
Eating disorders 2.10 1.20 3.01 0.46 5.29e-06
OCDs 2.98 2.25 3.71 0.37 1.74e-15
PTSD 4.09 3.36 4.81 0.37 3.05e-28
Depressive disorders 5.87 5.72 6.03 0.08 0.00e+00
Bipolar disorders 8.20 7.85 8.55 0.18 0.00e+00
Female 0.93 0.78 1.09 0.08 6.72e-32
Non-binary/Self-defined 2.50 1.88 3.12 0.32 3.22e-15
age_category_collapsed_reordered16-18 5.89 5.48 6.31 0.21 4.13e-167
19-25 years 2.29 2.00 2.57 0.15 5.42e-55
36-45 years -0.81 -1.05 -0.57 0.12 3.85e-11
46-55 years -1.27 -1.49 -1.05 0.11 1.39e-29
56-65 years -2.42 -2.64 -2.20 0.11 5.41e-103
66-70 years -3.62 -3.90 -3.34 0.14 1.04e-140
71-75 years -3.76 -4.08 -3.44 0.16 5.56e-115
76+ years -3.71 -4.20 -3.22 0.25 1.01e-49
Mixed or multiple ethnic origins 0.37 -0.13 0.86 0.25 0.15
Asian or Asian British -0.16 -0.77 0.45 0.31 0.60
African or African British -0.30 -1.41 0.81 0.57 0.60
Other ethnicity 1.14 0.29 2.00 0.44 0.009
Time difference: Lockdown to baseline -0.21 -0.24 -0.18 0.02 1.52e-36
n R2 adjust. R2 F p value df
32662 0.25 0.25 1854.75 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.36 6.04 6.68 0.16 3.95e-323
Depressive and anxiety disorder 5.55 5.38 5.71 0.08 0.00e+00
Only depressive disorder 3.37 3.16 3.57 0.11 1.32e-219
Only anxiety disorder 2.04 1.77 2.30 0.13 4.96e-52
Eating disorders 1.56 1.29 1.82 0.13 4.38e-31
OCDs 1.44 1.19 1.69 0.13 6.82e-29
Psychotic and bipolar disorder 0.55 -0.16 1.26 0.36 0.13
Only psychotic disorder 0.87 0.26 1.48 0.31 0.005
Only bipolar disorder 1.48 1.10 1.86 0.20 3.91e-14
PTSD 2.07 1.84 2.31 0.12 2.84e-67
ASD 1.47 1.01 1.93 0.23 3.78e-10
ADHD 1.10 0.50 1.71 0.31 3.54e-04
Personality disorder 3.05 2.72 3.39 0.17 5.49e-71
Female 0.84 0.68 0.99 0.08 5.13e-27
Non-binary/Self-defined 1.38 0.76 1.99 0.31 1.03e-05
age_category_collapsed_reordered16-18 5.94 5.54 6.34 0.20 4.13e-184
19-25 years 2.16 1.88 2.44 0.14 1.63e-51
36-45 years -0.60 -0.83 -0.36 0.12 5.81e-07
46-55 years -0.84 -1.05 -0.62 0.11 5.61e-14
56-65 years -1.91 -2.13 -1.69 0.11 1.08e-65
66-70 years -3.18 -3.46 -2.89 0.14 8.09e-108
71-75 years -3.36 -3.68 -3.04 0.16 6.23e-93
76+ years -3.22 -3.70 -2.74 0.24 1.05e-39
Mixed or multiple ethnic origins 0.37 -0.12 0.86 0.25 0.14
Asian or Asian British 0.29 -0.29 0.87 0.30 0.33
African or African British -0.26 -1.32 0.79 0.54 0.62
Other ethnicity 1.03 0.18 1.88 0.44 0.02
Key worker -0.68 -0.82 -0.54 0.07 4.66e-21
Time difference: Lockdown to baseline -0.22 -0.25 -0.19 0.02 1.38e-41
n R2 adjust. R2 F p value df
32662 0.25 0.25 1854.75 0.00e+00 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.25 1.90 2.59 0.18 2.77e-37
Anxiety disorders 2.02 1.68 2.37 0.18 2.63e-30
Eating disorders 2.31 1.27 3.35 0.53 1.43e-05
OCDs 3.91 3.01 4.82 0.46 2.59e-17
PTSD 3.93 2.95 4.91 0.50 3.25e-15
Depressive disorders 6.07 5.90 6.25 0.09 0.00e+00
Bipolar disorders 8.33 7.95 8.71 0.19 0.00e+00
Female 0.57 0.40 0.74 0.09 2.32e-11
Non-binary/Self-defined 2.11 1.44 2.78 0.34 6.82e-10
Age -285.84 -298.50 -273.17 6.46 0.00e+00
Age^2 31.24 19.79 42.69 5.84 9.08e-08
Mixed or multiple ethnic origins 0.43 -0.11 0.98 0.28 0.12
Asian or Asian British 0.02 -0.72 0.75 0.38 0.96
African or African British -0.18 -1.38 1.02 0.61 0.77
Other ethnicity 1.41 0.42 2.40 0.50 0.005
Time difference: Lockdown to baseline 0.10 0.06 0.15 0.02 1.93e-06
n R2 adjust. R2 F p value df
25344 0.31 0.31 1865.02 0.00e+00 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.66 2.32 3.00 0.17 1.80e-53
Depressive and anxiety disorder 5.83 5.65 6.02 0.09 0.00e+00
Only depressive disorder 3.60 3.37 3.84 0.12 8.27e-196
Only anxiety disorder 2.13 1.83 2.44 0.16 1.22e-41
Eating disorders 1.79 1.51 2.08 0.15 1.62e-34
OCDs 1.46 1.18 1.74 0.14 3.28e-25
Psychotic and bipolar disorder 0.34 -0.47 1.15 0.41 0.41
Only psychotic disorder 0.83 0.17 1.49 0.34 0.01
Only bipolar disorder 1.48 1.08 1.88 0.20 5.26e-13
PTSD 2.05 1.80 2.31 0.13 2.74e-55
ASD 1.57 1.04 2.10 0.27 6.15e-09
ADHD 0.77 0.06 1.47 0.36 0.03
Personality disorder 2.85 2.49 3.21 0.18 1.53e-53
Female 0.43 0.27 0.59 0.08 2.44e-07
Non-binary/Self-defined 1.09 0.43 1.74 0.34 0.001
Age -255.64 -268.55 -242.74 6.58 4.56e-319
Age^2 14.59 3.10 26.08 5.86 0.01
Mixed or multiple ethnic origins 0.34 -0.20 0.88 0.27 0.22
Asian or Asian British 0.38 -0.32 1.09 0.36 0.28
African or African British -0.23 -1.38 0.91 0.58 0.69
Other ethnicity 1.18 0.19 2.17 0.50 0.02
Key worker -0.71 -0.87 -0.56 0.08 4.35e-20
Time difference: Lockdown to baseline 0.10 0.05 0.14 0.02 4.77e-06
n R2 adjust. R2 F p value df
25344 0.31 0.31 1865.02 0.00e+00 6

PHQ prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.65 -2.63 -0.66 0.50 0.001
Anxiety disorders 1.89 0.81 2.98 0.55 6.12e-04
Eating disorders 0.01 -2.06 2.07 1.05 1.00
OCDs 1.87 0.42 3.32 0.74 0.01
PTSD 1.16 -0.51 2.83 0.85 0.17
Depressive disorders 1.24 0.25 2.22 0.50 0.01
Bipolar disorders 0.78 -0.27 1.84 0.54 0.15
n R2 adjust. R2 F p value df
11993 0.00 0.00 3.70 0.001 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.55 -2.26 -0.84 0.36 1.69e-05
Depressive and anxiety disorder 1.08 0.36 1.79 0.37 0.003
Only depressive disorder 0.94 0.16 1.71 0.39 0.02
Only anxiety disorder 1.75 0.94 2.56 0.41 2.28e-05
Eating disorders 0.37 0.02 0.72 0.18 0.04
OCDs 0.01 -0.32 0.33 0.17 0.96
Psychotic and bipolar disorder -0.79 -1.75 0.17 0.49 0.11
Only psychotic disorder 0.13 -0.66 0.92 0.40 0.75
Only bipolar disorder -0.32 -0.80 0.15 0.24 0.18
PTSD -0.17 -0.48 0.13 0.16 0.26
ASD 0.35 -0.28 0.98 0.32 0.28
ADHD 0.07 -0.79 0.93 0.44 0.87
Personality disorder -0.02 -0.44 0.41 0.22 0.93
n R2 adjust. R2 F p value df
11993 0.00 0.00 3.70 0.001 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.17 -3.31 -1.04 0.58 1.76e-04
Anxiety disorders 1.83 0.75 2.92 0.55 9.14e-04
Eating disorders -0.13 -2.19 1.93 1.05 0.90
OCDs 1.72 0.27 3.17 0.74 0.02
PTSD 0.95 -0.73 2.63 0.86 0.27
Depressive disorders 1.20 0.21 2.19 0.51 0.02
Bipolar disorders 0.83 -0.23 1.89 0.54 0.12
Female 0.31 0.03 0.58 0.14 0.03
Non-binary/Self-defined 0.07 -0.73 0.88 0.41 0.86
age_category_collapsed_reordered16-18 0.07 -0.62 0.75 0.35 0.85
19-25 years 0.07 -0.30 0.44 0.19 0.70
36-45 years 0.01 -0.31 0.33 0.16 0.95
46-55 years -0.30 -0.61 0.01 0.16 0.06
56-65 years -0.32 -0.66 0.03 0.18 0.07
66-70 years -0.23 -0.84 0.37 0.31 0.45
71-75 years -0.39 -1.19 0.41 0.41 0.34
76+ years -0.16 -1.67 1.34 0.77 0.83
Mixed or multiple ethnic origins -0.03 -0.75 0.69 0.37 0.94
Asian or Asian British -1.14 -2.32 0.04 0.60 0.06
African or African British -0.77 -2.66 1.12 0.96 0.42
Other ethnicity -0.28 -1.36 0.80 0.55 0.61
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.06
n R2 adjust. R2 F p value df
11993 0.00 0.00 3.70 0.001 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.14 -3.08 -1.21 0.48 6.68e-06
Depressive and anxiety disorder 1.09 0.37 1.81 0.37 0.003
Only depressive disorder 0.99 0.21 1.77 0.40 0.01
Only anxiety disorder 1.72 0.91 2.54 0.42 3.52e-05
Eating disorders 0.32 -0.03 0.68 0.18 0.07
OCDs -0.02 -0.34 0.31 0.17 0.92
Psychotic and bipolar disorder -0.69 -1.65 0.28 0.49 0.16
Only psychotic disorder 0.15 -0.65 0.94 0.41 0.72
Only bipolar disorder -0.22 -0.70 0.25 0.24 0.36
PTSD -0.17 -0.48 0.14 0.16 0.27
ASD 0.35 -0.29 0.99 0.33 0.29
ADHD 0.05 -0.81 0.91 0.44 0.91
Personality disorder -0.06 -0.48 0.37 0.22 0.80
Female 0.26 -0.04 0.55 0.15 0.09
Non-binary/Self-defined -0.11 -0.94 0.72 0.42 0.79
age_category_collapsed_reordered16-18 0.05 -0.64 0.74 0.35 0.90
19-25 years 0.04 -0.34 0.42 0.19 0.83
36-45 years -0.02 -0.35 0.31 0.17 0.92
46-55 years -0.32 -0.64 0.00 0.16 0.05
56-65 years -0.33 -0.69 0.04 0.19 0.08
66-70 years -0.20 -0.84 0.43 0.32 0.53
71-75 years -0.53 -1.38 0.32 0.43 0.22
76+ years 0.29 -1.36 1.94 0.84 0.73
Mixed or multiple ethnic origins 0.02 -0.73 0.77 0.38 0.96
Asian or Asian British -1.19 -2.41 0.03 0.62 0.06
African or African British -1.35 -3.29 0.59 0.99 0.17
Other ethnicity -0.22 -1.35 0.92 0.58 0.71
Key worker 0.12 -0.10 0.35 0.12 0.29
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.06
n R2 adjust. R2 F p value df
11993 0.00 0.00 3.70 0.001 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.30 -3.41 -1.18 0.57 5.43e-05
Anxiety disorders 1.84 0.76 2.92 0.55 8.70e-04
Eating disorders -0.12 -2.18 1.94 1.05 0.91
OCDs 1.72 0.27 3.17 0.74 0.02
PTSD 0.98 -0.70 2.66 0.86 0.25
Depressive disorders 1.21 0.22 2.20 0.50 0.02
Bipolar disorders 0.85 -0.21 1.91 0.54 0.12
Female 0.30 0.03 0.58 0.14 0.03
Non-binary/Self-defined 0.06 -0.74 0.87 0.41 0.88
Age -16.03 -27.79 -4.27 6.00 0.008
Age^2 0.42 -11.08 11.92 5.87 0.94
Mixed or multiple ethnic origins -0.03 -0.75 0.69 0.37 0.93
Asian or Asian British -1.13 -2.31 0.05 0.60 0.06
African or African British -0.78 -2.67 1.11 0.96 0.42
Other ethnicity -0.28 -1.36 0.80 0.55 0.61
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.06
n R2 adjust. R2 F p value df
11993 0.00 0.00 3.70 0.001 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.28 -3.18 -1.38 0.46 7.14e-07
Depressive and anxiety disorder 1.10 0.38 1.82 0.37 0.003
Only depressive disorder 1.00 0.22 1.78 0.40 0.01
Only anxiety disorder 1.73 0.91 2.55 0.42 3.20e-05
Eating disorders 0.32 -0.03 0.67 0.18 0.07
OCDs -0.02 -0.34 0.31 0.17 0.91
Psychotic and bipolar disorder -0.69 -1.65 0.27 0.49 0.16
Only psychotic disorder 0.16 -0.63 0.96 0.41 0.69
Only bipolar disorder -0.22 -0.69 0.26 0.24 0.37
PTSD -0.17 -0.48 0.13 0.16 0.26
ASD 0.34 -0.30 0.98 0.33 0.30
ADHD 0.06 -0.80 0.92 0.44 0.89
Personality disorder -0.06 -0.49 0.37 0.22 0.79
Female 0.25 -0.04 0.54 0.15 0.09
Non-binary/Self-defined -0.12 -0.95 0.71 0.42 0.77
Age -15.89 -28.30 -3.48 6.33 0.01
Age^2 0.65 -11.72 13.01 6.31 0.92
Mixed or multiple ethnic origins 0.02 -0.74 0.77 0.38 0.96
Asian or Asian British -1.19 -2.41 0.03 0.62 0.06
African or African British -1.37 -3.31 0.57 0.99 0.17
Other ethnicity -0.21 -1.35 0.92 0.58 0.71
Key worker 0.12 -0.11 0.34 0.12 0.31
Time difference: Lockdown to baseline 0.06 0.00 0.13 0.03 0.06
n R2 adjust. R2 F p value df
11993 0.00 0.00 3.70 0.001 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.19 1.30 3.07 0.45 1.23e-06
phq.sum_score_prepan 0.61 0.60 0.62 0.01 0.00e+00
Anxiety disorders 0.83 -0.13 1.80 0.49 0.09
Eating disorders 0.09 -1.75 1.92 0.94 0.93
OCDs 1.90 0.61 3.19 0.66 0.004
PTSD 1.04 -0.44 2.53 0.76 0.17
Depressive disorders 1.80 0.92 2.68 0.45 6.12e-05
Bipolar disorders 2.13 1.18 3.07 0.48 9.86e-06
n R2 adjust. R2 F p value df
11993 0.41 0.41 1167.23 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.76 2.12 3.40 0.33 3.18e-17
phq.sum_score_prepan 0.59 0.57 0.60 0.01 0.00e+00
Depressive and anxiety disorder 1.18 0.55 1.81 0.32 2.47e-04
Only depressive disorder 0.52 -0.16 1.20 0.35 0.13
Only anxiety disorder 0.40 -0.32 1.11 0.37 0.28
Eating disorders 1.02 0.72 1.33 0.16 6.68e-11
OCDs 0.68 0.39 0.96 0.15 4.12e-06
Psychotic and bipolar disorder -0.69 -1.53 0.16 0.43 0.11
Only psychotic disorder 0.19 -0.50 0.89 0.36 0.58
Only bipolar disorder 0.15 -0.27 0.56 0.21 0.49
PTSD 0.58 0.31 0.85 0.14 2.86e-05
ASD 1.04 0.48 1.59 0.28 2.62e-04
ADHD 0.46 -0.30 1.22 0.39 0.23
Personality disorder 1.28 0.90 1.66 0.19 3.03e-11
n R2 adjust. R2 F p value df
12024 0.02 0.02 41.62 1.65e-50 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.03 1.01 3.06 0.52 9.75e-05
phq.sum_score_prepan 0.58 0.57 0.59 0.01 0.00e+00
Anxiety disorders 0.75 -0.22 1.71 0.49 0.13
Eating disorders 0.00 -1.81 1.82 0.93 1.00
OCDs 1.58 0.30 2.86 0.65 0.02
PTSD 1.18 -0.30 2.66 0.76 0.12
Depressive disorders 2.00 1.12 2.88 0.45 8.24e-06
Bipolar disorders 2.48 1.54 3.42 0.48 2.52e-07
Female 0.34 0.10 0.58 0.12 0.006
Non-binary/Self-defined 0.80 0.09 1.50 0.36 0.03
age_category_collapsed_reordered16-18 1.81 1.19 2.42 0.31 7.75e-09
19-25 years 0.81 0.49 1.14 0.17 1.03e-06
36-45 years -0.20 -0.48 0.08 0.14 0.16
46-55 years -0.47 -0.75 -0.20 0.14 6.98e-04
56-65 years -1.06 -1.37 -0.76 0.16 1.50e-11
66-70 years -2.01 -2.55 -1.46 0.28 4.35e-13
71-75 years -2.46 -3.17 -1.75 0.36 1.42e-11
76+ years -2.29 -3.62 -0.97 0.68 7.11e-04
Mixed or multiple ethnic origins 0.10 -0.53 0.74 0.33 0.75
Asian or Asian British -0.80 -1.84 0.25 0.53 0.13
African or African British -0.25 -1.92 1.41 0.85 0.77
Other ethnicity 0.15 -0.80 1.10 0.49 0.76
Key worker -0.58 -0.77 -0.39 0.10 3.31e-09
Time difference: Lockdown to baseline 0.08 0.02 0.13 0.03 0.009
n R2 adjust. R2 F p value df
12024 0.02 0.02 41.62 1.65e-50 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.70 1.87 3.53 0.42 2.11e-10
phq.sum_score_prepan 0.56 0.55 0.58 0.01 0.00e+00
Depressive and anxiety disorder 1.35 0.71 1.98 0.32 2.96e-05
Only depressive disorder 0.90 0.22 1.58 0.35 0.010
Only anxiety disorder 0.30 -0.41 1.02 0.36 0.41
Eating disorders 0.92 0.62 1.23 0.16 3.68e-09
OCDs 0.57 0.28 0.86 0.15 9.46e-05
Psychotic and bipolar disorder -0.50 -1.34 0.34 0.43 0.25
Only psychotic disorder 0.24 -0.45 0.94 0.35 0.50
Only bipolar disorder 0.31 -0.10 0.73 0.21 0.14
PTSD 0.66 0.39 0.93 0.14 1.94e-06
ASD 0.68 0.13 1.24 0.29 0.02
ADHD 0.32 -0.43 1.08 0.39 0.40
Personality disorder 1.19 0.82 1.57 0.19 5.96e-10
Female 0.12 -0.14 0.37 0.13 0.37
Non-binary/Self-defined 0.28 -0.44 1.01 0.37 0.44
age_category_collapsed_reordered16-18 1.89 1.28 2.49 0.31 1.10e-09
19-25 years 0.83 0.50 1.16 0.17 8.76e-07
36-45 years -0.18 -0.47 0.11 0.15 0.23
46-55 years -0.35 -0.63 -0.07 0.14 0.02
56-65 years -0.90 -1.22 -0.58 0.16 4.07e-08
66-70 years -1.80 -2.36 -1.25 0.29 2.63e-10
71-75 years -2.30 -3.04 -1.55 0.38 1.62e-09
76+ years -1.68 -3.12 -0.23 0.74 0.02
Mixed or multiple ethnic origins 0.07 -0.59 0.73 0.34 0.83
Asian or Asian British -0.67 -1.74 0.39 0.54 0.21
African or African British -0.59 -2.28 1.11 0.87 0.50
Other ethnicity 0.21 -0.78 1.20 0.51 0.68
Key worker -0.45 -0.65 -0.25 0.10 8.96e-06
Time difference: Lockdown to baseline 0.07 0.01 0.13 0.03 0.02
n R2 adjust. R2 F p value df
12024 0.02 0.02 41.62 1.65e-50 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.77 0.77 2.78 0.51 5.39e-04
phq.sum_score_prepan 0.58 0.57 0.60 0.01 0.00e+00
Anxiety disorders 0.73 -0.23 1.69 0.49 0.14
Eating disorders -0.01 -1.83 1.81 0.93 0.99
OCDs 1.61 0.33 2.90 0.65 0.01
PTSD 1.11 -0.37 2.60 0.76 0.14
Depressive disorders 1.94 1.07 2.82 0.45 1.45e-05
Bipolar disorders 2.42 1.47 3.36 0.48 5.08e-07
Female 0.32 0.07 0.56 0.12 0.01
Non-binary/Self-defined 0.78 0.07 1.49 0.36 0.03
Age -80.86 -91.48 -70.25 5.42 5.90e-50
Age^2 -3.91 -14.34 6.52 5.32 0.46
Mixed or multiple ethnic origins 0.08 -0.56 0.72 0.33 0.81
Asian or Asian British -0.77 -1.82 0.27 0.53 0.15
African or African British -0.26 -1.93 1.40 0.85 0.76
Other ethnicity 0.16 -0.79 1.12 0.49 0.74
Key worker -0.59 -0.78 -0.40 0.10 1.71e-09
Time difference: Lockdown to baseline 0.08 0.02 0.14 0.03 0.007
n R2 adjust. R2 F p value df
12024 0.02 0.02 41.62 1.65e-50 6

Model 2b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.52 1.72 3.33 0.41 7.99e-10
phq.sum_score_prepan 0.57 0.55 0.58 0.01 0.00e+00
Depressive and anxiety disorder 1.26 0.63 1.89 0.32 9.04e-05
Only depressive disorder 0.84 0.16 1.52 0.35 0.02
Only anxiety disorder 0.26 -0.46 0.97 0.36 0.48
Eating disorders 0.93 0.62 1.24 0.16 2.88e-09
OCDs 0.56 0.28 0.85 0.15 1.16e-04
Psychotic and bipolar disorder -0.46 -1.31 0.38 0.43 0.28
Only psychotic disorder 0.27 -0.42 0.97 0.35 0.44
Only bipolar disorder 0.31 -0.11 0.73 0.21 0.14
PTSD 0.67 0.40 0.94 0.14 1.32e-06
ASD 0.74 0.18 1.30 0.29 0.009
ADHD 0.28 -0.47 1.04 0.39 0.47
Personality disorder 1.11 0.74 1.49 0.19 6.87e-09
Female 0.10 -0.16 0.35 0.13 0.46
Non-binary/Self-defined 0.26 -0.47 0.98 0.37 0.48
Age -74.08 -85.11 -63.04 5.63 3.00e-39
Age^2 -0.16 -10.98 10.66 5.52 0.98
Mixed or multiple ethnic origins 0.05 -0.61 0.71 0.34 0.87
Asian or Asian British -0.66 -1.73 0.40 0.54 0.22
African or African British -0.59 -2.29 1.10 0.87 0.49
Other ethnicity 0.20 -0.79 1.20 0.51 0.69
Key worker -0.46 -0.65 -0.26 0.10 6.81e-06
Time difference: Lockdown to baseline 0.07 0.01 0.13 0.03 0.02
n R2 adjust. R2 F p value df
12024 0.02 0.02 41.62 1.65e-50 6

PHQ prepan: sensitivity

Regression: Absolute scores

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline #### Subset of participants 3 months prior to pandemic

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.20 -0.23 4.63 1.24 0.08
phq.sum_score_prepan 0.64 0.59 0.69 0.03 1.62e-99
Depressive and anxiety disorder 0.09 -1.58 1.76 0.85 0.92
Only depressive disorder -0.11 -1.91 1.69 0.92 0.91
Only anxiety disorder -0.15 -2.15 1.85 1.02 0.88
Eating disorders 1.14 0.09 2.20 0.54 0.03
OCDs 0.04 -1.02 1.11 0.54 0.94
Psychotic and bipolar disorder -0.82 -3.46 1.83 1.35 0.55
Only psychotic disorder -0.84 -3.47 1.78 1.34 0.53
Only bipolar disorder -0.13 -1.80 1.53 0.85 0.88
PTSD 1.41 0.43 2.39 0.50 0.005
ASD 2.51 0.66 4.37 0.94 0.008
ADHD -1.75 -4.34 0.83 1.32 0.18
Personality disorder 0.46 -0.87 1.79 0.68 0.49
Female 0.41 -0.46 1.28 0.44 0.35
Non-binary/Self-defined 0.17 -3.00 3.33 1.61 0.92
age_category_collapsed_reordered16-18 1.56 -0.35 3.47 0.97 0.11
19-25 years 0.28 -1.00 1.56 0.65 0.67
36-45 years 0.24 -0.83 1.31 0.55 0.66
46-55 years -0.75 -1.82 0.32 0.55 0.17
56-65 years -0.06 -1.19 1.06 0.57 0.91
66-70 years -0.89 -2.89 1.11 1.02 0.38
71-75 years -2.96 -5.81 -0.11 1.45 0.04
76+ years 1.21 -2.30 4.72 1.79 0.50
Mixed or multiple ethnic origins -1.60 -3.90 0.70 1.17 0.17
Asian or Asian British -0.15 -3.81 3.51 1.86 0.94
African or African British -2.48 -6.81 1.85 2.21 0.26
Other ethnicity -2.58 -6.87 1.71 2.19 0.24
Key worker -0.18 -0.91 0.56 0.37 0.64
Time difference: Lockdown to baseline 0.06 -0.12 0.23 0.09 0.52
n R2 adjust. R2 F p value df
830 0.02 0.01 2.93 0.008 6

Subset of participants 6 months prior to pandemic

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.94 0.22 3.66 0.88 0.03
phq.sum_score_prepan 0.62 0.59 0.66 0.02 1.08e-190
Depressive and anxiety disorder 0.57 -0.55 1.68 0.57 0.32
Only depressive disorder 0.29 -0.93 1.52 0.62 0.64
Only anxiety disorder -0.13 -1.47 1.21 0.69 0.85
Eating disorders 1.35 0.58 2.13 0.39 5.91e-04
OCDs 0.40 -0.33 1.12 0.37 0.28
Psychotic and bipolar disorder -1.39 -3.53 0.75 1.09 0.20
Only psychotic disorder -0.05 -1.65 1.55 0.81 0.95
Only bipolar disorder -0.02 -1.11 1.07 0.55 0.97
PTSD 1.33 0.64 2.03 0.35 1.59e-04
ASD 1.25 -0.15 2.65 0.72 0.08
ADHD -1.00 -2.66 0.65 0.84 0.24
Personality disorder 1.35 0.40 2.29 0.48 0.005
Female 0.30 -0.32 0.92 0.32 0.34
Non-binary/Self-defined 0.53 -1.45 2.50 1.01 0.60
age_category_collapsed_reordered16-18 1.98 0.79 3.17 0.61 0.001
19-25 years 0.29 -0.61 1.20 0.46 0.53
36-45 years -0.38 -1.15 0.39 0.39 0.33
46-55 years -0.82 -1.58 -0.05 0.39 0.04
56-65 years -0.47 -1.29 0.34 0.41 0.25
66-70 years -1.28 -2.66 0.09 0.70 0.07
71-75 years -2.98 -4.65 -1.31 0.85 4.65e-04
76+ years -0.07 -2.60 2.45 1.29 0.95
Mixed or multiple ethnic origins -0.84 -2.44 0.76 0.82 0.30
Asian or Asian British -1.05 -3.18 1.07 1.09 0.33
African or African British -1.68 -5.27 1.91 1.83 0.36
Other ethnicity -1.30 -3.92 1.33 1.34 0.33
Key worker -0.23 -0.74 0.27 0.26 0.37
Time difference: Lockdown to baseline 0.09 -0.04 0.23 0.07 0.19
n R2 adjust. R2 F p value df
1636 0.02 0.02 5.43 1.42e-05 6

Subset of participants 9 months prior to pandemic

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.03 1.63 4.44 0.72 2.41e-05
phq.sum_score_prepan 0.60 0.57 0.63 0.01 8.22e-281
Depressive and anxiety disorder 0.78 -0.14 1.69 0.47 0.10
Only depressive disorder 0.51 -0.48 1.50 0.51 0.31
Only anxiety disorder -0.30 -1.41 0.81 0.57 0.60
Eating disorders 1.40 0.78 2.02 0.32 9.09e-06
OCDs 0.38 -0.21 0.96 0.30 0.20
Psychotic and bipolar disorder -0.73 -2.35 0.88 0.82 0.37
Only psychotic disorder 0.55 -0.74 1.84 0.66 0.40
Only bipolar disorder 0.40 -0.46 1.27 0.44 0.36
PTSD 1.17 0.63 1.72 0.28 2.57e-05
ASD 0.79 -0.34 1.93 0.58 0.17
ADHD -0.86 -2.27 0.54 0.72 0.23
Personality disorder 1.35 0.60 2.10 0.38 4.41e-04
Female -0.08 -0.57 0.41 0.25 0.75
Non-binary/Self-defined 0.11 -1.40 1.63 0.77 0.88
age_category_collapsed_reordered16-18 2.11 1.04 3.18 0.54 1.09e-04
19-25 years 0.37 -0.37 1.11 0.38 0.33
36-45 years -0.19 -0.80 0.42 0.31 0.54
46-55 years -0.43 -1.02 0.16 0.30 0.15
56-65 years -0.68 -1.32 -0.05 0.33 0.04
66-70 years -1.05 -2.10 -0.01 0.53 0.05
71-75 years -2.31 -3.60 -1.02 0.66 4.58e-04
76+ years -0.53 -2.72 1.65 1.11 0.63
Mixed or multiple ethnic origins 0.01 -1.39 1.42 0.72 0.98
Asian or Asian British -1.04 -2.77 0.70 0.88 0.24
African or African British -0.03 -2.96 2.91 1.50 0.99
Other ethnicity -1.26 -3.05 0.52 0.91 0.16
Key worker -0.37 -0.78 0.03 0.21 0.07
Time difference: Lockdown to baseline 0.00 -0.11 0.11 0.06 0.95
n R2 adjust. R2 F p value df
2714 0.03 0.03 13.11 1.12e-14 6

PHQ retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.04 2.90 3.18 0.07 0.00e+00
Anxiety disorders 0.64 0.32 0.96 0.16 8.21e-05
Eating disorders 0.55 -0.42 1.52 0.50 0.27
OCDs 1.05 0.28 1.82 0.39 0.008
PTSD 1.29 0.51 2.06 0.39 0.001
Depressive disorders 0.94 0.77 1.11 0.09 4.17e-27
Bipolar disorders 0.86 0.48 1.23 0.19 9.72e-06
n R2 adjust. R2 F p value df
20515 0.01 0.01 20.21 1.05e-23 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.08 2.95 3.22 0.07 0.00e+00
Depressive and anxiety disorder 0.74 0.56 0.92 0.09 1.08e-15
Only depressive disorder 0.41 0.17 0.65 0.12 8.67e-04
Only anxiety disorder 0.59 0.29 0.88 0.15 9.74e-05
Eating disorders 0.66 0.37 0.94 0.14 5.62e-06
OCDs 0.19 -0.08 0.47 0.14 0.16
Psychotic and bipolar disorder -0.92 -1.71 -0.14 0.40 0.02
Only psychotic disorder -0.55 -1.23 0.13 0.35 0.11
Only bipolar disorder -0.09 -0.51 0.34 0.22 0.69
PTSD 0.56 0.30 0.81 0.13 1.57e-05
ASD 0.51 0.02 1.00 0.25 0.04
ADHD 0.08 -0.57 0.73 0.33 0.80
Personality disorder 0.29 -0.07 0.65 0.18 0.11
n R2 adjust. R2 F p value df
20515 0.01 0.01 20.21 1.05e-23 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.53 4.16 4.90 0.19 4.74e-127
Anxiety disorders 0.23 -0.10 0.57 0.17 0.17
Eating disorders 0.01 -0.99 1.01 0.51 0.98
OCDs 0.29 -0.50 1.07 0.40 0.48
PTSD 0.95 0.15 1.75 0.41 0.02
Depressive disorders 0.70 0.51 0.89 0.10 3.78e-13
Bipolar disorders 0.68 0.29 1.08 0.20 6.16e-04
Female 0.74 0.55 0.94 0.10 8.94e-14
Non-binary/Self-defined 0.14 -0.52 0.80 0.34 0.67
age_category_collapsed_reordered16-18 1.35 0.93 1.77 0.22 4.11e-10
19-25 years 0.77 0.48 1.07 0.15 2.48e-07
36-45 years -0.47 -0.72 -0.21 0.13 3.52e-04
46-55 years -0.48 -0.72 -0.23 0.12 1.14e-04
56-65 years -0.63 -0.87 -0.38 0.13 5.72e-07
66-70 years -1.04 -1.40 -0.69 0.18 8.63e-09
71-75 years -1.12 -1.56 -0.68 0.22 5.65e-07
76+ years -1.35 -2.10 -0.59 0.38 4.61e-04
Mixed or multiple ethnic origins -0.22 -0.76 0.32 0.28 0.42
Asian or Asian British -0.28 -0.98 0.42 0.36 0.43
African or African British -0.60 -1.88 0.68 0.65 0.36
Other ethnicity -0.43 -1.33 0.47 0.46 0.35
Time difference: Lockdown to baseline -0.24 -0.27 -0.20 0.02 1.96e-37
n R2 adjust. R2 F p value df
20515 0.01 0.01 20.21 1.05e-23 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.36 3.98 4.73 0.19 3.49e-113
Depressive and anxiety disorder 0.58 0.38 0.78 0.10 1.04e-08
Only depressive disorder 0.45 0.20 0.71 0.13 5.60e-04
Only anxiety disorder 0.25 -0.06 0.57 0.16 0.11
Eating disorders 0.43 0.14 0.72 0.15 0.003
OCDs 0.04 -0.23 0.32 0.14 0.76
Psychotic and bipolar disorder -0.68 -1.47 0.11 0.40 0.09
Only psychotic disorder -0.42 -1.11 0.27 0.35 0.23
Only bipolar disorder 0.05 -0.38 0.48 0.22 0.83
PTSD 0.57 0.31 0.83 0.13 1.58e-05
ASD 0.19 -0.31 0.69 0.26 0.45
ADHD 0.00 -0.67 0.66 0.34 0.99
Personality disorder 0.25 -0.11 0.62 0.19 0.18
Female 0.68 0.48 0.88 0.10 1.92e-11
Non-binary/Self-defined 0.03 -0.64 0.71 0.34 0.92
age_category_collapsed_reordered16-18 1.59 1.17 2.02 0.22 1.43e-13
19-25 years 0.85 0.55 1.14 0.15 2.51e-08
36-45 years -0.42 -0.68 -0.16 0.13 0.002
46-55 years -0.41 -0.66 -0.17 0.13 0.001
56-65 years -0.50 -0.75 -0.24 0.13 1.22e-04
66-70 years -0.75 -1.12 -0.38 0.19 6.96e-05
71-75 years -0.88 -1.34 -0.43 0.23 1.41e-04
76+ years -1.14 -1.90 -0.38 0.39 0.003
Mixed or multiple ethnic origins -0.11 -0.66 0.44 0.28 0.69
Asian or Asian British 0.00 -0.69 0.68 0.35 0.99
African or African British -0.72 -1.99 0.54 0.64 0.26
Other ethnicity -0.22 -1.14 0.69 0.47 0.63
Key worker 0.26 0.09 0.42 0.08 0.002
Time difference: Lockdown to baseline -0.24 -0.27 -0.20 0.02 9.61e-37
n R2 adjust. R2 F p value df
20515 0.01 0.01 20.21 1.05e-23 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.54 2.12 2.96 0.21 1.17e-32
Anxiety disorders 0.27 -0.15 0.69 0.21 0.21
Eating disorders 0.16 -1.05 1.38 0.62 0.79
OCDs 0.16 -0.84 1.15 0.51 0.76
PTSD 1.00 -0.17 2.17 0.60 0.09
Depressive disorders 0.93 0.71 1.16 0.12 1.32e-15
Bipolar disorders 0.93 0.49 1.36 0.22 3.10e-05
Female 0.50 0.28 0.72 0.11 5.73e-06
Non-binary/Self-defined -0.51 -1.23 0.21 0.37 0.17
Age -94.43 -109.79 -79.08 7.83 2.67e-33
Age^2 8.59 -5.67 22.85 7.27 0.24
Mixed or multiple ethnic origins -0.34 -0.95 0.28 0.31 0.28
Asian or Asian British -0.54 -1.41 0.33 0.44 0.22
African or African British -0.27 -1.74 1.20 0.75 0.72
Other ethnicity -0.22 -1.27 0.83 0.54 0.68
Time difference: Lockdown to baseline -0.08 -0.13 -0.03 0.02 0.001
n R2 adjust. R2 F p value df
14828 0.01 0.01 31.26 1.47e-37 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.51 2.09 2.93 0.22 3.78e-31
Depressive and anxiety disorder 0.84 0.60 1.07 0.12 4.07e-12
Only depressive disorder 0.70 0.40 1.01 0.16 7.08e-06
Only anxiety disorder 0.28 -0.11 0.66 0.20 0.16
Eating disorders 0.36 0.04 0.68 0.16 0.03
OCDs -0.10 -0.40 0.21 0.16 0.53
Psychotic and bipolar disorder -0.54 -1.46 0.38 0.47 0.25
Only psychotic disorder -0.26 -1.01 0.49 0.38 0.50
Only bipolar disorder 0.01 -0.45 0.47 0.23 0.96
PTSD 0.64 0.35 0.93 0.15 1.51e-05
ASD -0.07 -0.65 0.52 0.30 0.83
ADHD 0.09 -0.70 0.88 0.40 0.82
Personality disorder 0.31 -0.09 0.72 0.21 0.13
Female 0.44 0.22 0.66 0.11 9.16e-05
Non-binary/Self-defined -0.65 -1.39 0.08 0.38 0.08
Age -86.23 -102.36 -70.11 8.23 1.32e-25
Age^2 16.24 1.43 31.06 7.56 0.03
Mixed or multiple ethnic origins -0.28 -0.91 0.34 0.32 0.37
Asian or Asian British -0.41 -1.27 0.45 0.44 0.35
African or African British -0.55 -2.01 0.92 0.75 0.47
Other ethnicity -0.08 -1.15 1.00 0.55 0.89
Key worker 0.27 0.09 0.45 0.09 0.004
Time difference: Lockdown to baseline -0.08 -0.13 -0.03 0.02 7.64e-04
n R2 adjust. R2 F p value df
14828 0.01 0.01 31.26 1.47e-37 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.80 1.72 1.88 0.04 0.00e+00
phq.sum_score_retro 0.77 0.76 0.78 0.01 0.00e+00
Anxiety disorders 1.88 1.66 2.11 0.11 1.22e-61
Eating disorders 2.02 1.31 2.74 0.36 2.84e-08
OCDs 2.88 2.31 3.46 0.30 1.53e-22
PTSD 2.65 2.10 3.21 0.28 1.15e-20
Depressive disorders 3.15 3.03 3.27 0.06 0.00e+00
Bipolar disorders 3.78 3.49 4.07 0.15 8.33e-140
n R2 adjust. R2 F p value df
30794 0.59 0.59 6280.68 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.98 1.90 2.06 0.04 0.00e+00
phq.sum_score_retro 0.74 0.73 0.75 0.01 0.00e+00
Depressive and anxiety disorder 3.16 3.03 3.29 0.07 0.00e+00
Only depressive disorder 1.71 1.55 1.87 0.08 1.30e-95
Only anxiety disorder 1.86 1.65 2.06 0.10 2.39e-70
Eating disorders 1.06 0.85 1.28 0.11 4.35e-22
OCDs 0.68 0.47 0.89 0.11 1.39e-10
Psychotic and bipolar disorder -0.44 -1.04 0.15 0.30 0.14
Only psychotic disorder -0.09 -0.60 0.42 0.26 0.73
Only bipolar disorder 0.41 0.09 0.73 0.16 0.01
PTSD 0.87 0.68 1.07 0.10 3.33e-19
ASD 1.20 0.82 1.57 0.19 3.39e-10
ADHD 0.61 0.11 1.10 0.25 0.02
Personality disorder 0.99 0.71 1.26 0.14 2.18e-12
n R2 adjust. R2 F p value df
30959 0.28 0.28 2029.98 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.19 3.92 4.45 0.14 3.76e-206
phq.sum_score_retro 0.71 0.70 0.72 0.01 0.00e+00
Anxiety disorders 1.19 0.96 1.42 0.12 2.19e-23
Eating disorders 1.09 0.36 1.81 0.37 0.003
OCDs 1.47 0.88 2.06 0.30 9.93e-07
PTSD 2.16 1.58 2.73 0.29 2.71e-13
Depressive disorders 2.72 2.59 2.85 0.07 0.00e+00
Bipolar disorders 3.49 3.19 3.79 0.15 3.14e-115
Female 0.80 0.67 0.92 0.06 1.35e-35
Non-binary/Self-defined 0.86 0.36 1.36 0.25 6.80e-04
age_category_collapsed_reordered16-18 2.61 2.28 2.94 0.17 4.62e-53
19-25 years 1.20 0.98 1.43 0.12 4.25e-25
36-45 years -0.62 -0.81 -0.43 0.10 2.37e-10
46-55 years -0.85 -1.03 -0.67 0.09 5.88e-21
56-65 years -1.43 -1.61 -1.25 0.09 5.93e-56
66-70 years -2.14 -2.37 -1.91 0.12 1.58e-73
71-75 years -2.28 -2.55 -2.02 0.13 2.12e-64
76+ years -2.33 -2.73 -1.94 0.20 1.31e-30
Mixed or multiple ethnic origins -0.01 -0.40 0.39 0.20 0.97
Asian or Asian British -0.28 -0.76 0.21 0.25 0.26
African or African British -0.39 -1.27 0.50 0.45 0.39
Other ethnicity 0.19 -0.50 0.88 0.35 0.59
Key worker -0.13 -0.25 -0.02 0.06 0.02
Time difference: Lockdown to baseline -0.21 -0.24 -0.19 0.01 3.54e-56
n R2 adjust. R2 F p value df
30959 0.28 0.28 2029.98 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.15 3.88 4.41 0.13 2.40e-205
phq.sum_score_retro 0.68 0.67 0.69 0.01 0.00e+00
Depressive and anxiety disorder 2.74 2.60 2.89 0.07 1.04e-296
Only depressive disorder 1.71 1.54 1.88 0.09 1.70e-84
Only anxiety disorder 1.21 0.99 1.42 0.11 4.98e-28
Eating disorders 0.75 0.54 0.97 0.11 1.06e-11
OCDs 0.44 0.23 0.65 0.11 3.16e-05
Psychotic and bipolar disorder -0.15 -0.74 0.44 0.30 0.61
Only psychotic disorder 0.12 -0.39 0.63 0.26 0.64
Only bipolar disorder 0.65 0.33 0.97 0.16 7.93e-05
PTSD 0.97 0.78 1.17 0.10 7.29e-23
ASD 0.62 0.24 1.00 0.19 0.001
ADHD 0.28 -0.22 0.78 0.25 0.27
Personality disorder 1.03 0.75 1.30 0.14 3.60e-13
Female 0.75 0.62 0.87 0.06 1.30e-31
Non-binary/Self-defined 0.49 -0.01 0.98 0.25 0.06
age_category_collapsed_reordered16-18 2.99 2.67 3.32 0.17 2.89e-72
19-25 years 1.25 1.02 1.47 0.12 7.36e-27
36-45 years -0.53 -0.72 -0.34 0.10 7.52e-08
46-55 years -0.69 -0.87 -0.52 0.09 2.93e-14
56-65 years -1.19 -1.37 -1.01 0.09 1.11e-38
66-70 years -1.82 -2.05 -1.59 0.12 1.17e-53
71-75 years -1.99 -2.25 -1.72 0.13 2.64e-49
76+ years -2.03 -2.42 -1.64 0.20 2.82e-24
Mixed or multiple ethnic origins 0.05 -0.35 0.45 0.20 0.80
Asian or Asian British 0.03 -0.44 0.50 0.24 0.90
African or African British -0.42 -1.28 0.45 0.44 0.35
Other ethnicity 0.36 -0.34 1.06 0.36 0.31
Key worker -0.05 -0.16 0.07 0.06 0.44
Time difference: Lockdown to baseline -0.22 -0.24 -0.19 0.01 1.48e-59
n R2 adjust. R2 F p value df
30959 0.28 0.28 2029.98 0.00e+00 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.65 1.38 1.93 0.14 6.97e-33
phq.sum_score_retro 0.72 0.70 0.73 0.01 0.00e+00
Anxiety disorders 1.09 0.82 1.36 0.14 2.68e-15
Eating disorders 1.14 0.32 1.96 0.42 0.006
OCDs 1.69 0.98 2.41 0.36 3.40e-06
PTSD 1.90 1.15 2.65 0.38 7.24e-07
Depressive disorders 2.82 2.67 2.97 0.07 9.31e-302
Bipolar disorders 3.58 3.27 3.90 0.16 2.80e-109
Female 0.50 0.37 0.63 0.07 3.21e-14
Non-binary/Self-defined 0.31 -0.21 0.83 0.26 0.25
Age -155.11 -165.11 -145.10 5.10 1.61e-198
Age^2 13.96 5.07 22.84 4.53 0.002
Mixed or multiple ethnic origins -0.08 -0.51 0.34 0.22 0.71
Asian or Asian British -0.24 -0.80 0.32 0.29 0.41
African or African British -0.23 -1.14 0.69 0.47 0.63
Other ethnicity 0.36 -0.43 1.14 0.40 0.37
Key worker -0.14 -0.26 -0.02 0.06 0.03
Time difference: Lockdown to baseline -0.01 -0.05 0.02 0.02 0.41
n R2 adjust. R2 F p value df
23649 0.34 0.34 2058.71 0.00e+00 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.71 1.44 1.98 0.14 1.32e-35
phq.sum_score_retro 0.69 0.68 0.70 0.01 0.00e+00
Depressive and anxiety disorder 2.90 2.74 3.06 0.08 1.35e-276
Only depressive disorder 1.83 1.64 2.02 0.10 6.00e-80
Only anxiety disorder 1.22 0.98 1.47 0.13 3.79e-22
Eating disorders 0.78 0.55 1.01 0.12 2.25e-11
OCDs 0.37 0.14 0.59 0.11 0.001
Psychotic and bipolar disorder -0.12 -0.78 0.55 0.34 0.73
Only psychotic disorder 0.24 -0.30 0.78 0.27 0.39
Only bipolar disorder 0.61 0.28 0.94 0.17 2.75e-04
PTSD 0.96 0.76 1.17 0.10 5.13e-20
ASD 0.49 0.06 0.91 0.22 0.03
ADHD 0.31 -0.26 0.88 0.29 0.28
Personality disorder 0.96 0.68 1.25 0.15 6.37e-11
Female 0.43 0.30 0.56 0.07 6.92e-11
Non-binary/Self-defined -0.04 -0.56 0.48 0.26 0.89
Age -140.98 -151.08 -130.87 5.16 1.02e-161
Age^2 15.80 7.01 24.59 4.48 4.26e-04
Mixed or multiple ethnic origins -0.08 -0.50 0.35 0.22 0.73
Asian or Asian British -0.04 -0.59 0.50 0.28 0.88
African or African British -0.34 -1.25 0.56 0.46 0.45
Other ethnicity 0.42 -0.38 1.21 0.41 0.30
Key worker -0.05 -0.17 0.07 0.06 0.45
Time difference: Lockdown to baseline -0.01 -0.05 0.02 0.02 0.41
n R2 adjust. R2 F p value df
23649 0.34 0.34 2058.71 0.00e+00 6

PHQ retro: Sensitivity

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.75 1.62 3.89 0.58 2.08e-06
Anxiety disorders 0.64 -0.62 1.90 0.64 0.32
Eating disorders 0.84 -1.60 3.28 1.24 0.50
OCDs 0.72 -0.94 2.39 0.85 0.40
PTSD 1.21 -0.70 3.12 0.98 0.21
Depressive disorders 0.98 -0.17 2.12 0.58 0.09
Bipolar disorders 0.74 -0.48 1.97 0.62 0.23
n R2 adjust. R2 F p value df
8919 0.00 0.00 0.85 0.53 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.95 2.13 3.77 0.42 1.94e-12
Depressive and anxiety disorder 0.68 -0.16 1.51 0.42 0.11
Only depressive disorder 0.48 -0.42 1.38 0.46 0.30
Only anxiety disorder 0.50 -0.44 1.44 0.48 0.30
Eating disorders 0.55 0.16 0.95 0.20 0.006
OCDs -0.12 -0.49 0.24 0.19 0.51
Psychotic and bipolar disorder -0.74 -1.85 0.38 0.57 0.19
Only psychotic disorder -0.46 -1.38 0.47 0.47 0.33
Only bipolar disorder -0.27 -0.81 0.27 0.28 0.33
PTSD 0.43 0.09 0.78 0.18 0.01
ASD 0.01 -0.70 0.71 0.36 0.99
ADHD 0.27 -0.72 1.26 0.50 0.59
Personality disorder 0.38 -0.10 0.86 0.25 0.12
n R2 adjust. R2 F p value df
8919 0.00 0.00 0.85 0.53 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.97 1.66 4.27 0.67 8.24e-06
Anxiety disorders 0.52 -0.73 1.77 0.64 0.42
Eating disorders 0.56 -1.87 2.98 1.24 0.65
OCDs 0.39 -1.27 2.05 0.85 0.64
PTSD 1.22 -0.70 3.13 0.98 0.21
Depressive disorders 1.02 -0.12 2.16 0.58 0.08
Bipolar disorders 0.94 -0.28 2.17 0.62 0.13
Female 0.54 0.22 0.87 0.17 0.001
Non-binary/Self-defined -0.40 -1.29 0.50 0.46 0.39
age_category_collapsed_reordered16-18 0.67 -0.06 1.40 0.37 0.07
19-25 years 0.60 0.21 1.00 0.20 0.003
36-45 years -0.42 -0.78 -0.06 0.18 0.02
46-55 years -0.47 -0.82 -0.12 0.18 0.009
56-65 years -1.12 -1.53 -0.72 0.21 5.27e-08
66-70 years -1.29 -2.05 -0.53 0.39 9.31e-04
71-75 years -2.13 -3.18 -1.08 0.54 7.08e-05
76+ years -1.91 -4.03 0.21 1.08 0.08
Mixed or multiple ethnic origins -0.60 -1.39 0.20 0.41 0.14
Asian or Asian British -0.85 -2.14 0.43 0.66 0.19
African or African British -0.44 -2.55 1.67 1.08 0.68
Other ethnicity -0.40 -1.61 0.82 0.62 0.52
Time difference: Lockdown to baseline -0.05 -0.12 0.02 0.04 0.17
n R2 adjust. R2 F p value df
8919 0.00 0.00 0.85 0.53 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.08 2.01 4.15 0.55 1.94e-08
Depressive and anxiety disorder 0.76 -0.07 1.60 0.43 0.07
Only depressive disorder 0.80 -0.11 1.70 0.46 0.09
Only anxiety disorder 0.42 -0.52 1.37 0.48 0.38
Eating disorders 0.40 0.01 0.80 0.20 0.05
OCDs -0.17 -0.54 0.19 0.19 0.36
Psychotic and bipolar disorder -0.48 -1.59 0.63 0.57 0.40
Only psychotic disorder -0.23 -1.15 0.70 0.47 0.63
Only bipolar disorder -0.10 -0.65 0.44 0.28 0.71
PTSD 0.48 0.13 0.83 0.18 0.007
ASD -0.08 -0.80 0.63 0.36 0.82
ADHD 0.28 -0.70 1.27 0.50 0.57
Personality disorder 0.32 -0.17 0.80 0.25 0.20
Female 0.49 0.15 0.84 0.18 0.005
Non-binary/Self-defined -0.55 -1.47 0.37 0.47 0.24
age_category_collapsed_reordered16-18 0.80 0.06 1.54 0.38 0.03
19-25 years 0.64 0.23 1.05 0.21 0.002
36-45 years -0.37 -0.74 0.00 0.19 0.05
46-55 years -0.41 -0.78 -0.04 0.19 0.03
56-65 years -1.09 -1.51 -0.66 0.22 6.08e-07
66-70 years -1.02 -1.82 -0.22 0.41 0.01
71-75 years -1.72 -2.85 -0.59 0.58 0.003
76+ years -1.75 -3.99 0.50 1.15 0.13
Mixed or multiple ethnic origins -0.58 -1.41 0.25 0.42 0.17
Asian or Asian British -0.75 -2.07 0.56 0.67 0.26
African or African British -0.89 -3.08 1.30 1.12 0.43
Other ethnicity -0.20 -1.46 1.05 0.64 0.75
Key worker 0.24 -0.01 0.50 0.13 0.06
Time difference: Lockdown to baseline -0.06 -0.14 0.01 0.04 0.10
n R2 adjust. R2 F p value df
8919 0.00 0.00 0.85 0.53 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.51 3.57 5.44 0.48 3.31e-21
phq.sum_score_retro 0.66 0.65 0.68 0.01 0.00e+00
Anxiety disorders 0.17 -0.86 1.19 0.52 0.75
Eating disorders 0.88 -1.10 2.86 1.01 0.38
OCDs 1.13 -0.24 2.50 0.70 0.10
PTSD 1.04 -0.51 2.60 0.79 0.19
Depressive disorders 1.53 0.60 2.47 0.48 0.001
Bipolar disorders 2.00 1.00 3.00 0.51 9.19e-05
n R2 adjust. R2 F p value df
10344 0.40 0.40 995.05 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.05 4.38 5.72 0.34 6.74e-49
phq.sum_score_retro 0.64 0.62 0.65 0.01 0.00e+00
Depressive and anxiety disorder 0.93 0.26 1.60 0.34 0.007
Only depressive disorder 0.37 -0.35 1.10 0.37 0.31
Only anxiety disorder -0.17 -0.93 0.59 0.39 0.66
Eating disorders 0.97 0.65 1.29 0.16 2.92e-09
OCDs 0.46 0.16 0.76 0.15 0.002
Psychotic and bipolar disorder -0.62 -1.52 0.28 0.46 0.18
Only psychotic disorder -0.06 -0.80 0.69 0.38 0.88
Only bipolar disorder 0.26 -0.18 0.70 0.23 0.25
PTSD 0.72 0.44 1.00 0.14 4.41e-07
ASD 0.71 0.13 1.29 0.30 0.02
ADHD 0.48 -0.31 1.28 0.41 0.23
Personality disorder 1.24 0.85 1.63 0.20 5.05e-10
n R2 adjust. R2 F p value df
10375 0.02 0.02 38.52 1.50e-46 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.46 3.38 5.53 0.55 5.91e-16
phq.sum_score_retro 0.64 0.63 0.66 0.01 0.00e+00
Anxiety disorders 0.17 -0.85 1.19 0.52 0.74
Eating disorders 0.86 -1.10 2.81 1.00 0.39
OCDs 0.90 -0.46 2.25 0.69 0.20
PTSD 1.36 -0.19 2.90 0.79 0.09
Depressive disorders 1.83 0.90 2.76 0.48 1.20e-04
Bipolar disorders 2.47 1.47 3.47 0.51 1.34e-06
Female 0.37 0.10 0.63 0.13 0.006
Non-binary/Self-defined 0.38 -0.35 1.11 0.37 0.31
age_category_collapsed_reordered16-18 1.87 1.26 2.49 0.31 2.66e-09
19-25 years 0.99 0.66 1.32 0.17 4.21e-09
36-45 years -0.44 -0.73 -0.15 0.15 0.003
46-55 years -0.47 -0.75 -0.18 0.15 0.001
56-65 years -1.23 -1.56 -0.90 0.17 3.59e-13
66-70 years -2.05 -2.67 -1.44 0.31 6.56e-11
71-75 years -2.89 -3.72 -2.06 0.42 8.05e-12
76+ years -2.40 -4.09 -0.71 0.86 0.005
Mixed or multiple ethnic origins -0.18 -0.84 0.47 0.34 0.58
Asian or Asian British -0.38 -1.47 0.70 0.55 0.49
African or African British 0.01 -1.74 1.77 0.90 0.99
Other ethnicity -0.07 -1.07 0.93 0.51 0.89
Key worker -0.34 -0.54 -0.14 0.10 9.84e-04
Time difference: Lockdown to baseline 0.01 -0.05 0.07 0.03 0.80
n R2 adjust. R2 F p value df
10375 0.02 0.02 38.52 1.50e-46 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.17 4.30 6.04 0.44 4.18e-31
phq.sum_score_retro 0.62 0.60 0.64 0.01 0.00e+00
Depressive and anxiety disorder 1.13 0.46 1.80 0.34 9.16e-04
Only depressive disorder 0.84 0.12 1.56 0.37 0.02
Only anxiety disorder -0.23 -0.99 0.52 0.39 0.55
Eating disorders 0.83 0.51 1.15 0.16 3.03e-07
OCDs 0.37 0.07 0.66 0.15 0.02
Psychotic and bipolar disorder -0.40 -1.29 0.49 0.46 0.38
Only psychotic disorder 0.10 -0.64 0.84 0.38 0.79
Only bipolar disorder 0.44 0.00 0.88 0.22 0.05
PTSD 0.82 0.54 1.10 0.14 1.17e-08
ASD 0.38 -0.21 0.96 0.30 0.21
ADHD 0.40 -0.40 1.19 0.40 0.33
Personality disorder 1.17 0.78 1.56 0.20 3.90e-09
Female 0.17 -0.11 0.45 0.14 0.23
Non-binary/Self-defined -0.04 -0.78 0.71 0.38 0.92
age_category_collapsed_reordered16-18 2.00 1.39 2.62 0.31 1.51e-10
19-25 years 1.00 0.67 1.34 0.17 5.10e-09
36-45 years -0.38 -0.68 -0.08 0.15 0.01
46-55 years -0.36 -0.65 -0.06 0.15 0.02
56-65 years -1.11 -1.45 -0.77 0.17 2.29e-10
66-70 years -1.80 -2.44 -1.17 0.32 2.73e-08
71-75 years -2.47 -3.34 -1.59 0.45 3.27e-08
76+ years -2.02 -3.81 -0.23 0.91 0.03
Mixed or multiple ethnic origins -0.29 -0.97 0.38 0.34 0.40
Asian or Asian British -0.24 -1.34 0.86 0.56 0.67
African or African British -0.23 -2.04 1.58 0.92 0.80
Other ethnicity 0.01 -1.02 1.03 0.52 0.99
Key worker -0.23 -0.44 -0.02 0.11 0.03
Time difference: Lockdown to baseline 0.00 -0.07 0.06 0.03 0.89
n R2 adjust. R2 F p value df
10375 0.02 0.02 38.52 1.50e-46 6

OCI-R baseline, not controlling for prior symptoms

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.34 11.53 13.16 0.42 9.64e-180
Anxiety disorders 2.31 0.88 3.74 0.73 0.002
Eating disorders 4.27 0.08 8.46 2.14 0.05
OCDs 10.28 7.63 12.93 1.35 3.09e-14
PTSD 8.12 5.24 11.00 1.47 3.29e-08
Depressive disorders 5.75 4.84 6.66 0.47 1.47e-34
Bipolar disorders 12.55 10.96 14.15 0.81 7.29e-53
n R2 adjust. R2 F p value df
5506 0.05 0.05 52.82 1.41e-63 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 13.33 12.63 14.03 0.36 1.93e-271
Depressive and anxiety disorder 2.50 1.63 3.36 0.44 1.64e-08
Only depressive disorder -0.78 -1.98 0.41 0.61 0.20
Only anxiety disorder 0.78 -0.45 2.01 0.63 0.21
Eating disorders 0.62 -0.45 1.68 0.54 0.26
OCDs 7.47 6.53 8.41 0.48 1.21e-53
Psychotic and bipolar disorder 7.02 4.50 9.54 1.29 5.11e-08
Only psychotic disorder 4.35 2.05 6.65 1.17 2.09e-04
Only bipolar disorder 3.31 1.66 4.97 0.84 8.90e-05
PTSD 1.96 1.03 2.89 0.47 3.42e-05
ASD 9.07 7.38 10.75 0.86 7.54e-26
ADHD 2.71 0.39 5.03 1.18 0.02
Personality disorder 3.43 2.16 4.71 0.65 1.23e-07
n R2 adjust. R2 F p value df
5506 0.05 0.05 52.82 1.41e-63 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.38 13.71 17.04 0.85 3.30e-71
Anxiety disorders 1.84 0.41 3.28 0.73 0.01
Eating disorders 3.36 -0.83 7.55 2.14 0.12
OCDs 8.52 5.89 11.16 1.34 2.50e-10
PTSD 7.96 5.09 10.83 1.46 5.63e-08
Depressive disorders 6.01 5.07 6.96 0.48 2.87e-35
Bipolar disorders 12.47 10.87 14.08 0.82 1.51e-51
Female -0.73 -1.67 0.21 0.48 0.13
Non-binary/Self-defined 1.61 -0.94 4.16 1.30 0.22
age_category_collapsed_reordered16-18 7.91 6.31 9.50 0.81 3.32e-22
19-25 years 1.66 0.38 2.95 0.65 0.01
36-45 years -0.49 -1.68 0.69 0.61 0.42
46-55 years -0.49 -1.58 0.59 0.55 0.37
56-65 years -1.81 -2.89 -0.72 0.55 0.001
66-70 years -2.72 -4.31 -1.13 0.81 7.77e-04
71-75 years -3.08 -5.02 -1.14 0.99 0.002
76+ years -4.78 -8.31 -1.25 1.80 0.008
Mixed or multiple ethnic origins 0.83 -1.43 3.09 1.15 0.47
Asian or Asian British 3.54 0.50 6.58 1.55 0.02
African or African British 2.32 -3.95 8.60 3.20 0.47
Other ethnicity 3.13 -0.02 6.28 1.61 0.05
Time difference: Lockdown to baseline -0.41 -0.57 -0.25 0.08 4.16e-07
n R2 adjust. R2 F p value df
5506 0.05 0.05 52.82 1.41e-63 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.69 14.10 17.29 0.81 4.80e-80
Depressive and anxiety disorder 3.35 2.45 4.24 0.46 3.23e-13
Only depressive disorder 0.33 -0.87 1.54 0.62 0.59
Only anxiety disorder 0.91 -0.32 2.15 0.63 0.15
Eating disorders 0.25 -0.81 1.31 0.54 0.64
OCDs 7.02 6.09 7.96 0.48 2.90e-48
Psychotic and bipolar disorder 6.99 4.50 9.48 1.27 3.90e-08
Only psychotic disorder 3.92 1.66 6.18 1.15 6.92e-04
Only bipolar disorder 3.26 1.62 4.91 0.84 1.03e-04
PTSD 2.28 1.36 3.21 0.47 1.41e-06
ASD 7.51 5.82 9.21 0.86 4.75e-18
ADHD 1.65 -0.64 3.95 1.17 0.16
Personality disorder 3.37 2.10 4.63 0.64 1.79e-07
Female -0.85 -1.76 0.06 0.47 0.07
Non-binary/Self-defined -1.10 -3.60 1.41 1.28 0.39
age_category_collapsed_reordered16-18 8.09 6.56 9.61 0.78 5.13e-25
19-25 years 1.69 0.46 2.92 0.63 0.007
36-45 years -0.02 -1.18 1.13 0.59 0.97
46-55 years 0.15 -0.91 1.22 0.54 0.78
56-65 years -0.65 -1.72 0.42 0.54 0.23
66-70 years -0.82 -2.40 0.77 0.81 0.31
71-75 years -1.92 -3.83 -0.01 0.97 0.05
76+ years -3.54 -7.04 -0.05 1.78 0.05
Mixed or multiple ethnic origins 0.65 -1.56 2.86 1.13 0.56
Asian or Asian British 5.19 2.33 8.06 1.46 3.88e-04
African or African British 1.28 -4.65 7.22 3.03 0.67
Other ethnicity 2.43 -0.68 5.54 1.59 0.12
Key worker -1.06 -1.76 -0.35 0.36 0.003
Time difference: Lockdown to baseline -0.39 -0.54 -0.24 0.08 5.53e-07
n R2 adjust. R2 F p value df
5506 0.05 0.05 52.82 1.41e-63 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.16 3.43 8.88 1.39 9.68e-06
Anxiety disorders 0.18 -2.63 2.99 1.43 0.90
Eating disorders 8.05 2.14 13.96 3.01 0.008
OCDs 11.14 6.59 15.69 2.32 1.68e-06
PTSD 9.60 3.66 15.54 3.03 0.002
Depressive disorders 7.16 5.35 8.98 0.93 1.58e-14
Bipolar disorders 12.37 9.88 14.85 1.27 4.57e-22
Female -0.33 -1.66 1.00 0.68 0.63
Non-binary/Self-defined 2.76 -0.74 6.26 1.78 0.12
Age -223.09 -319.84 -126.35 49.33 6.43e-06
Age^2 -37.53 -127.18 52.12 45.72 0.41
Mixed or multiple ethnic origins 1.70 -1.44 4.84 1.60 0.29
Asian or Asian British 8.95 2.90 14.99 3.08 0.004
African or African British 5.00 -4.52 14.51 4.85 0.30
Other ethnicity 4.69 0.18 9.20 2.30 0.04
Time difference: Lockdown to baseline 0.31 0.05 0.58 0.13 0.02
n R2 adjust. R2 F p value df
2442 0.07 0.06 29.25 5.42e-34 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.02 5.45 10.60 1.31 1.18e-09
Depressive and anxiety disorder 4.48 2.85 6.11 0.83 8.44e-08
Only depressive disorder 2.32 0.14 4.49 1.11 0.04
Only anxiety disorder 0.91 -1.42 3.24 1.19 0.45
Eating disorders 1.43 -0.01 2.86 0.73 0.05
OCDs 6.91 5.65 8.18 0.65 3.75e-26
Psychotic and bipolar disorder 6.18 2.53 9.84 1.86 9.26e-04
Only psychotic disorder 3.00 0.05 5.95 1.50 0.05
Only bipolar disorder 3.50 1.40 5.60 1.07 0.001
PTSD 2.22 0.96 3.48 0.64 5.45e-04
ASD 6.09 3.39 8.79 1.38 9.99e-06
ADHD 0.08 -3.75 3.91 1.95 0.97
Personality disorder 2.78 1.12 4.43 0.85 0.001
Female -0.74 -2.05 0.56 0.66 0.26
Non-binary/Self-defined 1.37 -2.09 4.82 1.76 0.44
Age -169.39 -266.76 -72.01 49.66 6.58e-04
Age^2 -38.86 -128.13 50.41 45.52 0.39
Mixed or multiple ethnic origins 1.12 -1.96 4.19 1.57 0.48
Asian or Asian British 8.94 2.96 14.92 3.05 0.003
African or African British -0.06 -9.99 9.88 5.06 0.99
Other ethnicity 2.81 -1.66 7.28 2.28 0.22
Key worker -1.40 -2.40 -0.40 0.51 0.006
Time difference: Lockdown to baseline 0.26 0.01 0.52 0.13 0.04
n R2 adjust. R2 F p value df
2442 0.07 0.06 29.25 5.42e-34 6

OCIR prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.00 -10.13 14.13 6.17 0.75
Anxiety disorders -10.07 -23.35 3.22 6.76 0.14
Eating disorders -8.00 -27.17 11.17 9.76 0.41
OCDs -12.64 -26.32 1.04 6.96 0.07
PTSD -24.50 -43.67 -5.33 9.76 0.01
Depressive disorders -10.13 -22.30 2.05 6.19 0.10
Bipolar disorders -9.66 -22.17 2.85 6.36 0.13
n R2 adjust. R2 F p value df
461 0.02 0.00 1.18 0.31 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.97 -9.82 5.88 3.99 0.62
Depressive and anxiety disorder -4.69 -12.65 3.26 4.05 0.25
Only depressive disorder -4.49 -13.22 4.24 4.44 0.31
Only anxiety disorder -8.20 -16.94 0.54 4.45 0.07
Eating disorders -0.11 -2.79 2.58 1.37 0.94
OCDs -1.25 -3.47 0.98 1.13 0.27
Psychotic and bipolar disorder 12.95 5.33 20.57 3.88 9.07e-04
Only psychotic disorder -0.95 -6.48 4.59 2.82 0.74
Only bipolar disorder -1.15 -4.80 2.50 1.86 0.54
PTSD -3.79 -6.25 -1.33 1.25 0.003
ASD -0.45 -4.77 3.88 2.20 0.84
ADHD 6.08 -0.41 12.57 3.30 0.07
Personality disorder -1.65 -4.91 1.61 1.66 0.32
n R2 adjust. R2 F p value df
461 0.02 0.00 1.18 0.31 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.73 -12.15 15.61 7.06 0.81
Anxiety disorders -9.13 -22.53 4.28 6.82 0.18
Eating disorders -6.64 -25.80 12.52 9.75 0.50
OCDs -11.81 -25.60 1.98 7.02 0.09
PTSD -22.97 -42.22 -3.71 9.80 0.02
Depressive disorders -10.12 -22.45 2.20 6.27 0.11
Bipolar disorders -10.10 -22.75 2.54 6.43 0.12
Female -2.04 -4.91 0.82 1.46 0.16
Non-binary/Self-defined -2.54 -8.26 3.19 2.91 0.38
age_category_collapsed_reordered16-18 -7.40 -14.32 -0.48 3.52 0.04
19-25 years -3.91 -6.81 -1.01 1.48 0.008
36-45 years -0.20 -3.22 2.82 1.54 0.90
46-55 years -0.20 -3.10 2.70 1.47 0.89
56-65 years -1.80 -5.35 1.75 1.81 0.32
66-70 years -0.80 -7.09 5.49 3.20 0.80
71-75 years 0.67 -11.43 12.78 6.16 0.91
Mixed or multiple ethnic origins 1.93 -4.21 8.07 3.12 0.54
Asian or Asian British -25.05 -39.75 -10.34 7.48 8.84e-04
Other ethnicity 1.40 -6.63 9.43 4.09 0.73
Time difference: Lockdown to baseline 0.48 -0.27 1.22 0.38 0.21
n R2 adjust. R2 F p value df
461 0.02 0.00 1.18 0.31 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -3.71 -14.48 7.07 5.48 0.50
Depressive and anxiety disorder -4.21 -13.00 4.57 4.47 0.35
Only depressive disorder -4.39 -13.86 5.09 4.82 0.36
Only anxiety disorder -6.76 -16.26 2.74 4.83 0.16
Eating disorders 0.17 -2.56 2.90 1.39 0.90
OCDs -1.18 -3.43 1.07 1.14 0.30
Psychotic and bipolar disorder 11.07 3.34 18.80 3.93 0.005
Only psychotic disorder -1.49 -7.14 4.17 2.88 0.61
Only bipolar disorder -1.14 -4.87 2.58 1.89 0.55
PTSD -3.44 -5.98 -0.91 1.29 0.008
ASD -0.41 -4.79 3.96 2.22 0.85
ADHD 5.05 -1.48 11.59 3.32 0.13
Personality disorder -1.01 -4.29 2.28 1.67 0.55
Female -1.99 -5.10 1.12 1.58 0.21
Non-binary/Self-defined -1.89 -7.96 4.18 3.09 0.54
age_category_collapsed_reordered16-18 -6.38 -13.25 0.49 3.49 0.07
19-25 years -3.47 -6.45 -0.50 1.51 0.02
36-45 years -0.49 -3.58 2.60 1.57 0.75
46-55 years -0.07 -3.09 2.96 1.54 0.97
56-65 years -2.03 -5.77 1.72 1.91 0.29
66-70 years -0.94 -7.31 5.43 3.24 0.77
71-75 years 2.45 -8.30 13.20 5.47 0.65
Mixed or multiple ethnic origins 2.72 -3.98 9.43 3.41 0.42
Asian or Asian British -22.95 -37.79 -8.11 7.55 0.003
Other ethnicity 1.09 -6.91 9.09 4.07 0.79
Key worker 1.19 -1.02 3.40 1.12 0.29
Time difference: Lockdown to baseline 0.52 -0.24 1.27 0.38 0.18
n R2 adjust. R2 F p value df
461 0.02 0.00 1.18 0.31 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.84 -12.78 14.45 6.93 0.90
Anxiety disorders -10.00 -23.22 3.22 6.73 0.14
Eating disorders -6.07 -25.01 12.87 9.64 0.53
OCDs -11.91 -25.40 1.58 6.86 0.08
PTSD -24.07 -43.05 -5.09 9.66 0.01
Depressive disorders -10.26 -22.36 1.84 6.16 0.10
Bipolar disorders -10.55 -22.99 1.89 6.33 0.10
Female -1.93 -4.78 0.92 1.45 0.18
Non-binary/Self-defined -2.35 -8.04 3.34 2.90 0.42
Age 44.09 -77.37 165.55 61.80 0.48
Age^2 -166.87 -292.03 -41.71 63.68 0.009
Mixed or multiple ethnic origins 1.67 -4.43 7.78 3.11 0.59
Asian or Asian British -25.30 -39.96 -10.64 7.46 7.58e-04
Other ethnicity 1.91 -6.05 9.88 4.05 0.64
Time difference: Lockdown to baseline 0.46 -0.27 1.20 0.37 0.22
n R2 adjust. R2 F p value df
461 0.02 0.00 1.18 0.31 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -3.72 -14.08 6.64 5.27 0.48
Depressive and anxiety disorder -4.92 -13.51 3.68 4.37 0.26
Only depressive disorder -5.54 -14.81 3.74 4.72 0.24
Only anxiety disorder -7.95 -17.28 1.38 4.74 0.09
Eating disorders 0.13 -2.59 2.85 1.38 0.92
OCDs -1.26 -3.50 0.97 1.13 0.27
Psychotic and bipolar disorder 10.67 2.96 18.37 3.92 0.007
Only psychotic disorder -1.46 -7.04 4.12 2.84 0.61
Only bipolar disorder -1.38 -5.08 2.31 1.88 0.46
PTSD -3.64 -6.16 -1.12 1.28 0.005
ASD -0.23 -4.58 4.13 2.22 0.92
ADHD 5.38 -1.11 11.86 3.30 0.10
Personality disorder -1.16 -4.42 2.11 1.66 0.49
Female -2.04 -5.14 1.05 1.57 0.19
Non-binary/Self-defined -1.90 -7.92 4.12 3.06 0.54
Age 43.48 -82.96 169.93 64.32 0.50
Age^2 -132.59 -260.35 -4.83 64.99 0.04
Mixed or multiple ethnic origins 2.71 -3.96 9.39 3.40 0.42
Asian or Asian British -23.00 -37.79 -8.22 7.52 0.002
Other ethnicity 1.39 -6.54 9.32 4.04 0.73
Key worker 1.23 -0.98 3.43 1.12 0.27
Time difference: Lockdown to baseline 0.50 -0.24 1.25 0.38 0.19
n R2 adjust. R2 F p value df
461 0.02 0.00 1.18 0.31 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.46 -1.49 20.41 5.57 0.09
ocir.sum_score_prepan 0.66 0.59 0.72 0.03 3.75e-65
Anxiety disorders -11.47 -23.37 0.44 6.06 0.06
Eating disorders -9.26 -26.44 7.92 8.74 0.29
OCDs -9.17 -21.44 3.10 6.24 0.14
PTSD -20.94 -38.13 -3.75 8.75 0.02
Depressive disorders -8.48 -19.39 2.43 5.55 0.13
Bipolar disorders -6.31 -17.53 4.92 5.71 0.27
n R2 adjust. R2 F p value df
461 0.49 0.48 62.80 7.79e-63 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.70 -1.50 12.89 3.66 0.12
ocir.sum_score_prepan 0.64 0.57 0.71 0.04 1.22e-53
Depressive and anxiety disorder -4.17 -11.31 2.97 3.63 0.25
Only depressive disorder -5.37 -13.21 2.46 3.99 0.18
Only anxiety disorder -8.62 -16.46 -0.78 3.99 0.03
Eating disorders 0.48 -1.94 2.89 1.23 0.70
OCDs 2.28 0.17 4.39 1.07 0.03
Psychotic and bipolar disorder 11.83 4.99 18.67 3.48 7.37e-04
Only psychotic disorder 0.58 -4.40 5.55 2.53 0.82
Only bipolar disorder 0.87 -2.43 4.17 1.68 0.61
PTSD -2.65 -4.87 -0.43 1.13 0.02
ASD 0.22 -3.66 4.10 1.97 0.91
ADHD 4.02 -1.82 9.85 2.97 0.18
Personality disorder -0.69 -3.62 2.25 1.49 0.65
n R2 adjust. R2 F p value df
1873 0.03 0.03 9.40 3.43e-10 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 13.35 -2.05 28.75 7.83 0.09
ocir.sum_score_prepan 0.67 0.61 0.74 0.03 3.92e-63
Anxiety disorders -15.91 -30.60 -1.22 7.47 0.03
Eating disorders -13.43 -32.72 5.85 9.81 0.17
OCDs -14.01 -28.97 0.95 7.61 0.07
PTSD -25.33 -44.69 -5.98 9.85 0.01
Depressive disorders -13.55 -27.42 0.32 7.06 0.06
Bipolar disorders -11.59 -25.69 2.52 7.18 0.11
Female -1.34 -3.96 1.27 1.33 0.31
Non-binary/Self-defined -1.34 -6.56 3.88 2.66 0.61
age_category_collapsed_reordered16-18 -6.36 -12.72 0.00 3.24 0.05
19-25 years -1.93 -4.61 0.75 1.36 0.16
36-45 years 0.05 -2.70 2.80 1.40 0.97
46-55 years 0.33 -2.32 2.98 1.35 0.81
56-65 years -1.28 -4.54 1.97 1.66 0.44
66-70 years -1.43 -7.21 4.36 2.94 0.63
71-75 years -3.50 -14.59 7.59 5.64 0.54
Mixed or multiple ethnic origins 0.20 -5.40 5.79 2.85 0.94
Asian or Asian British -16.52 -30.07 -2.98 6.89 0.02
Other ethnicity 4.05 -3.28 11.39 3.73 0.28
Key worker 0.24 -1.69 2.17 0.98 0.80
Time difference: Lockdown to baseline 0.35 -0.33 1.03 0.35 0.31
n R2 adjust. R2 F p value df
1873 0.03 0.03 9.40 3.43e-10 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.89 -5.04 14.82 5.05 0.33
ocir.sum_score_prepan 0.65 0.57 0.72 0.04 6.31e-51
Depressive and anxiety disorder -5.03 -12.99 2.93 4.05 0.22
Only depressive disorder -6.08 -14.67 2.51 4.37 0.17
Only anxiety disorder -8.82 -17.44 -0.20 4.38 0.04
Eating disorders 0.93 -1.55 3.41 1.26 0.46
OCDs 2.33 0.17 4.50 1.10 0.03
Psychotic and bipolar disorder 10.56 3.55 17.56 3.56 0.003
Only psychotic disorder 0.15 -4.98 5.29 2.61 0.95
Only bipolar disorder 0.65 -2.75 4.04 1.73 0.71
PTSD -2.35 -4.66 -0.04 1.17 0.05
ASD -0.13 -4.09 3.84 2.02 0.95
ADHD 3.38 -2.55 9.31 3.02 0.26
Personality disorder -0.16 -3.14 2.81 1.52 0.91
Female -1.95 -4.77 0.86 1.43 0.17
Non-binary/Self-defined -1.31 -6.81 4.19 2.80 0.64
age_category_collapsed_reordered16-18 -5.33 -11.56 0.90 3.17 0.09
19-25 years -1.37 -4.11 1.36 1.39 0.32
36-45 years -0.10 -2.90 2.70 1.42 0.94
46-55 years 1.36 -1.40 4.12 1.40 0.33
56-65 years -1.93 -5.32 1.47 1.73 0.27
66-70 years -1.19 -6.96 4.58 2.94 0.69
71-75 years -0.08 -9.84 9.68 4.96 0.99
Mixed or multiple ethnic origins 0.09 -6.01 6.19 3.10 0.98
Asian or Asian British -12.68 -26.30 0.94 6.93 0.07
Other ethnicity 3.67 -3.60 10.94 3.70 0.32
Key worker 0.09 -1.92 2.11 1.02 0.93
Time difference: Lockdown to baseline 0.47 -0.22 1.15 0.35 0.18
n R2 adjust. R2 F p value df
1873 0.03 0.03 9.40 3.43e-10 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 11.54 -3.40 26.48 7.60 0.13
ocir.sum_score_prepan 0.67 0.61 0.74 0.03 1.32e-64
Anxiety disorders -15.13 -29.48 -0.77 7.30 0.04
Eating disorders -11.52 -30.43 7.38 9.62 0.23
OCDs -12.50 -27.01 2.01 7.38 0.09
PTSD -24.50 -43.44 -5.56 9.64 0.01
Depressive disorders -12.25 -25.74 1.23 6.86 0.07
Bipolar disorders -10.43 -24.17 3.32 6.99 0.14
Female -1.26 -3.86 1.34 1.32 0.34
Non-binary/Self-defined -1.17 -6.34 4.01 2.63 0.66
Age 4.97 -107.16 117.10 57.05 0.93
Age^2 -138.61 -253.83 -23.39 58.63 0.02
Mixed or multiple ethnic origins 0.14 -5.40 5.69 2.82 0.96
Asian or Asian British -16.84 -30.31 -3.37 6.85 0.01
Other ethnicity 4.19 -3.06 11.44 3.69 0.26
Key worker 0.15 -1.77 2.08 0.98 0.88
Time difference: Lockdown to baseline 0.34 -0.33 1.01 0.34 0.32
n R2 adjust. R2 F p value df
1873 0.03 0.03 9.40 3.43e-10 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.99 -4.56 14.54 4.86 0.30
ocir.sum_score_prepan 0.65 0.58 0.72 0.04 5.45e-53
Depressive and anxiety disorder -5.00 -12.78 2.78 3.96 0.21
Only depressive disorder -6.50 -14.90 1.90 4.27 0.13
Only anxiety disorder -9.10 -17.55 -0.65 4.30 0.03
Eating disorders 0.80 -1.67 3.26 1.25 0.53
OCDs 2.13 -0.01 4.27 1.09 0.05
Psychotic and bipolar disorder 10.35 3.37 17.33 3.55 0.004
Only psychotic disorder -0.07 -5.14 4.99 2.58 0.98
Only bipolar disorder 0.64 -2.73 4.02 1.72 0.71
PTSD -2.55 -4.84 -0.25 1.17 0.03
ASD 0.15 -3.79 4.10 2.01 0.94
ADHD 3.39 -2.50 9.27 2.99 0.26
Personality disorder -0.37 -3.33 2.60 1.51 0.81
Female -1.94 -4.74 0.86 1.42 0.17
Non-binary/Self-defined -1.21 -6.66 4.24 2.77 0.66
Age 12.53 -102.14 127.20 58.33 0.83
Age^2 -116.94 -232.66 -1.21 58.87 0.05
Mixed or multiple ethnic origins 0.29 -5.77 6.35 3.09 0.93
Asian or Asian British -13.24 -26.78 0.30 6.89 0.06
Other ethnicity 3.58 -3.62 10.78 3.66 0.33
Key worker 0.06 -1.95 2.07 1.02 0.95
Time difference: Lockdown to baseline 0.42 -0.26 1.10 0.34 0.22
n R2 adjust. R2 F p value df
1873 0.03 0.03 9.40 3.43e-10 6

OCIR retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.87 3.16 4.58 0.36 3.40e-26
Anxiety disorders -0.58 -1.82 0.67 0.64 0.36
Eating disorders -3.63 -7.20 -0.06 1.82 0.05
OCDs -1.87 -4.16 0.42 1.17 0.11
PTSD 1.25 -1.19 3.70 1.25 0.31
Depressive disorders -3.76 -4.55 -2.97 0.40 1.37e-20
Bipolar disorders -3.66 -4.97 -2.35 0.67 4.34e-08
n R2 adjust. R2 F p value df
4580 0.03 0.02 20.52 7.79e-24 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.83 3.19 4.47 0.33 4.95e-31
Depressive and anxiety disorder -4.38 -5.16 -3.60 0.40 6.75e-28
Only depressive disorder -2.10 -3.19 -1.02 0.55 1.50e-04
Only anxiety disorder -1.43 -2.54 -0.31 0.57 0.01
Eating disorders -0.26 -1.19 0.67 0.48 0.59
OCDs 0.32 -0.49 1.13 0.41 0.43
Psychotic and bipolar disorder 2.21 0.02 4.40 1.12 0.05
Only psychotic disorder 0.57 -1.39 2.53 1.00 0.57
Only bipolar disorder -0.56 -1.93 0.82 0.70 0.43
PTSD 0.21 -0.58 1.00 0.40 0.60
ASD 1.83 0.35 3.32 0.76 0.02
ADHD 2.29 0.19 4.39 1.07 0.03
Personality disorder -0.61 -1.70 0.47 0.55 0.27
n R2 adjust. R2 F p value df
4580 0.03 0.02 20.52 7.79e-24 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 11.16 9.83 12.49 0.68 6.08e-59
Anxiety disorders -0.15 -1.34 1.03 0.60 0.80
Eating disorders -2.14 -5.45 1.17 1.69 0.21
OCDs -0.31 -2.46 1.84 1.10 0.78
PTSD 1.06 -1.24 3.36 1.17 0.37
Depressive disorders -2.01 -2.78 -1.24 0.39 3.43e-07
Bipolar disorders -1.75 -2.99 -0.50 0.63 0.006
Female 0.45 -0.29 1.19 0.38 0.24
Non-binary/Self-defined 0.14 -1.87 2.15 1.02 0.89
age_category_collapsed_reordered16-18 4.16 2.78 5.54 0.70 3.81e-09
19-25 years -0.46 -1.47 0.54 0.51 0.36
36-45 years 0.29 -0.63 1.20 0.46 0.54
46-55 years 0.31 -0.53 1.15 0.43 0.47
56-65 years 2.12 1.27 2.96 0.43 9.76e-07
66-70 years 2.04 0.77 3.32 0.65 0.002
71-75 years 2.83 1.26 4.40 0.80 4.03e-04
76+ years 0.53 -2.66 3.73 1.63 0.74
Mixed or multiple ethnic origins 1.18 -0.57 2.92 0.89 0.19
Asian or Asian British 2.45 -0.20 5.10 1.35 0.07
African or African British 0.16 -4.88 5.20 2.57 0.95
Other ethnicity -0.25 -2.64 2.13 1.22 0.84
Time difference: Lockdown to baseline -1.66 -1.78 -1.54 0.06 5.47e-142
n R2 adjust. R2 F p value df
4580 0.03 0.02 20.52 7.79e-24 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 11.20 9.85 12.54 0.69 5.09e-58
Depressive and anxiety disorder -2.52 -3.29 -1.76 0.39 1.03e-10
Only depressive disorder -1.45 -2.49 -0.41 0.53 0.006
Only anxiety disorder -0.73 -1.79 0.33 0.54 0.18
Eating disorders -0.09 -0.96 0.78 0.44 0.83
OCDs 0.39 -0.37 1.15 0.39 0.31
Psychotic and bipolar disorder 2.26 0.22 4.29 1.04 0.03
Only psychotic disorder 0.29 -1.53 2.11 0.93 0.75
Only bipolar disorder -0.32 -1.62 0.97 0.66 0.62
PTSD 0.16 -0.59 0.91 0.38 0.68
ASD 0.99 -0.43 2.40 0.72 0.17
ADHD 1.72 -0.23 3.66 0.99 0.08
Personality disorder -0.24 -1.25 0.77 0.52 0.64
Female 0.30 -0.46 1.06 0.39 0.43
Non-binary/Self-defined -0.66 -2.72 1.40 1.05 0.53
age_category_collapsed_reordered16-18 4.02 2.65 5.40 0.70 1.03e-08
19-25 years -0.47 -1.49 0.55 0.52 0.36
36-45 years 0.24 -0.69 1.17 0.48 0.61
46-55 years 0.28 -0.59 1.14 0.44 0.53
56-65 years 1.85 0.97 2.73 0.45 3.94e-05
66-70 years 2.18 0.85 3.52 0.68 0.001
71-75 years 2.14 0.52 3.76 0.83 0.010
76+ years 0.02 -3.33 3.37 1.71 0.99
Mixed or multiple ethnic origins 1.39 -0.41 3.19 0.92 0.13
Asian or Asian British 2.32 -0.29 4.92 1.33 0.08
African or African British -0.61 -5.84 4.61 2.66 0.82
Other ethnicity -0.16 -2.65 2.32 1.27 0.90
Key worker -0.09 -0.67 0.48 0.29 0.75
Time difference: Lockdown to baseline -1.61 -1.73 -1.48 0.06 1.65e-131
n R2 adjust. R2 F p value df
4580 0.03 0.02 20.52 7.79e-24 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -3.81 -5.41 -2.22 0.81 3.00e-06
Anxiety disorders -0.48 -2.13 1.16 0.84 0.56
Eating disorders 1.22 -2.21 4.65 1.75 0.49
OCDs -1.12 -3.76 1.52 1.35 0.40
PTSD -2.84 -6.28 0.60 1.76 0.11
Depressive disorders -0.89 -1.95 0.16 0.54 0.10
Bipolar disorders -1.24 -2.69 0.20 0.74 0.09
Female -0.39 -1.17 0.39 0.40 0.32
Non-binary/Self-defined -0.35 -2.39 1.68 1.04 0.73
Age 93.66 38.04 149.28 28.36 9.74e-04
Age^2 -24.39 -75.68 26.90 26.15 0.35
Mixed or multiple ethnic origins 2.58 0.75 4.42 0.94 0.006
Asian or Asian British 0.03 -3.47 3.54 1.79 0.98
African or African British 1.60 -3.92 7.12 2.81 0.57
Other ethnicity 1.06 -1.56 3.68 1.33 0.43
Time difference: Lockdown to baseline -0.01 -0.17 0.14 0.08 0.87
n R2 adjust. R2 F p value df
2385 0.00 0.00 1.87 0.08 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -3.52 -5.11 -1.93 0.81 1.42e-05
Depressive and anxiety disorder -0.70 -1.70 0.31 0.51 0.17
Only depressive disorder -1.16 -2.50 0.18 0.68 0.09
Only anxiety disorder -1.07 -2.50 0.35 0.73 0.14
Eating disorders 0.46 -0.42 1.34 0.45 0.31
OCDs -0.24 -1.01 0.54 0.39 0.55
Psychotic and bipolar disorder 0.50 -1.75 2.75 1.15 0.66
Only psychotic disorder 0.13 -1.69 1.94 0.92 0.89
Only bipolar disorder -0.24 -1.51 1.04 0.65 0.72
PTSD -0.56 -1.33 0.21 0.39 0.16
ASD 0.01 -1.65 1.67 0.85 0.99
ADHD 2.03 -0.36 4.42 1.22 0.10
Personality disorder -0.87 -1.89 0.14 0.52 0.09
Female -0.57 -1.37 0.23 0.41 0.16
Non-binary/Self-defined -0.93 -3.04 1.17 1.07 0.39
Age 83.90 25.33 142.47 29.87 0.005
Age^2 -29.91 -83.48 23.66 27.32 0.27
Mixed or multiple ethnic origins 2.75 0.87 4.64 0.96 0.004
Asian or Asian British -1.48 -5.12 2.16 1.86 0.42
African or African British -0.61 -6.65 5.43 3.08 0.84
Other ethnicity 1.43 -1.29 4.15 1.39 0.30
Key worker 0.10 -0.51 0.72 0.31 0.74
Time difference: Lockdown to baseline -0.03 -0.19 0.12 0.08 0.68
n R2 adjust. R2 F p value df
2385 0.00 0.00 1.87 0.08 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.42 5.72 7.12 0.36 5.01e-70
ocir.sum_score_retro 0.73 0.71 0.75 0.01 0.00e+00
Anxiety disorders 0.19 -0.99 1.36 0.60 0.75
Eating disorders -1.55 -4.91 1.81 1.71 0.37
OCDs 1.43 -0.74 3.60 1.11 0.20
PTSD 3.21 0.91 5.51 1.17 0.006
Depressive disorders -1.36 -2.12 -0.59 0.39 5.20e-04
Bipolar disorders 0.37 -0.90 1.65 0.65 0.57
n R2 adjust. R2 F p value df
4580 0.52 0.51 693.97 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.91 6.27 7.56 0.33 2.08e-93
ocir.sum_score_retro 0.70 0.68 0.73 0.01 0.00e+00
Depressive and anxiety disorder -2.54 -3.28 -1.80 0.38 2.15e-11
Only depressive disorder -1.69 -2.71 -0.68 0.52 0.001
Only anxiety disorder -0.70 -1.74 0.35 0.53 0.19
Eating disorders -0.08 -0.95 0.79 0.44 0.85
OCDs 2.48 1.71 3.25 0.39 3.42e-10
Psychotic and bipolar disorder 3.46 1.41 5.50 1.04 9.23e-04
Only psychotic disorder 1.71 -0.12 3.54 0.93 0.07
Only bipolar disorder 0.58 -0.71 1.87 0.66 0.38
PTSD 0.77 0.03 1.51 0.38 0.04
ASD 3.76 2.36 5.15 0.71 1.32e-07
ADHD 2.12 0.17 4.08 1.00 0.03
Personality disorder 0.66 -0.35 1.68 0.52 0.20
n R2 adjust. R2 F p value df
5455 0.06 0.05 53.30 3.86e-64 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.70 11.41 14.00 0.66 6.39e-79
ocir.sum_score_retro 0.77 0.75 0.79 0.01 0.00e+00
Anxiety disorders 0.27 -0.86 1.39 0.57 0.64
Eating disorders -0.82 -3.97 2.33 1.61 0.61
OCDs 1.68 -0.39 3.74 1.05 0.11
PTSD 2.70 0.49 4.91 1.13 0.02
Depressive disorders -0.37 -1.12 0.38 0.38 0.33
Bipolar disorders 1.20 -0.02 2.42 0.62 0.05
Female 0.39 -0.31 1.10 0.36 0.28
Non-binary/Self-defined 0.75 -1.16 2.66 0.97 0.44
age_category_collapsed_reordered16-18 4.76 3.43 6.09 0.68 2.37e-12
19-25 years -0.13 -1.09 0.83 0.49 0.78
36-45 years 0.00 -0.87 0.86 0.44 0.99
46-55 years 0.10 -0.70 0.90 0.41 0.80
56-65 years 1.28 0.46 2.09 0.41 0.002
66-70 years 0.99 -0.25 2.22 0.63 0.12
71-75 years 1.06 -0.46 2.58 0.77 0.17
76+ years -0.63 -3.72 2.46 1.58 0.69
Mixed or multiple ethnic origins 1.12 -0.56 2.79 0.85 0.19
Asian or Asian British 3.14 0.62 5.66 1.29 0.01
African or African British 0.32 -4.47 5.11 2.45 0.90
Other ethnicity 0.58 -1.70 2.87 1.17 0.62
Key worker -0.45 -0.99 0.08 0.27 0.10
Time difference: Lockdown to baseline -1.42 -1.54 -1.30 0.06 7.09e-113
n R2 adjust. R2 F p value df
5455 0.06 0.05 53.30 3.86e-64 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.79 11.51 14.07 0.65 1.21e-81
ocir.sum_score_retro 0.75 0.72 0.77 0.01 0.00e+00
Depressive and anxiety disorder -1.21 -1.94 -0.47 0.37 0.001
Only depressive disorder -1.01 -1.99 -0.03 0.50 0.04
Only anxiety disorder -0.29 -1.30 0.71 0.51 0.57
Eating disorders -0.04 -0.86 0.79 0.42 0.93
OCDs 2.12 1.39 2.85 0.37 1.40e-08
Psychotic and bipolar disorder 3.32 1.38 5.25 0.98 7.68e-04
Only psychotic disorder 1.21 -0.51 2.93 0.88 0.17
Only bipolar disorder 0.56 -0.67 1.78 0.63 0.37
PTSD 0.70 -0.01 1.41 0.36 0.05
ASD 2.50 1.15 3.84 0.69 2.72e-04
ADHD 1.53 -0.31 3.38 0.94 0.10
Personality disorder 0.74 -0.22 1.70 0.49 0.13
Female 0.17 -0.55 0.88 0.37 0.65
Non-binary/Self-defined -0.53 -2.48 1.43 1.00 0.60
age_category_collapsed_reordered16-18 5.03 3.72 6.33 0.67 4.96e-14
19-25 years 0.04 -0.92 1.01 0.49 0.93
36-45 years 0.11 -0.77 1.00 0.45 0.80
46-55 years 0.25 -0.57 1.08 0.42 0.54
56-65 years 1.31 0.47 2.14 0.43 0.002
66-70 years 1.55 0.29 2.81 0.64 0.02
71-75 years 1.18 -0.36 2.72 0.79 0.13
76+ years -0.82 -3.99 2.35 1.62 0.61
Mixed or multiple ethnic origins 1.16 -0.55 2.86 0.87 0.18
Asian or Asian British 3.38 0.91 5.84 1.26 0.007
African or African British -0.84 -5.78 4.11 2.52 0.74
Other ethnicity 0.58 -1.77 2.93 1.20 0.63
Key worker -0.42 -0.96 0.13 0.28 0.13
Time difference: Lockdown to baseline -1.35 -1.47 -1.23 0.06 1.83e-101
n R2 adjust. R2 F p value df
5455 0.06 0.05 53.30 3.86e-64 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.67 -3.21 -0.13 0.78 0.03
ocir.sum_score_retro 0.81 0.79 0.83 0.01 0.00e+00
Anxiety disorders -0.37 -1.92 1.17 0.79 0.64
Eating disorders 2.52 -0.70 5.73 1.64 0.12
OCDs 1.19 -1.30 3.68 1.27 0.35
PTSD -0.45 -3.69 2.79 1.65 0.79
Depressive disorders 0.62 -0.39 1.63 0.52 0.23
Bipolar disorders 1.45 0.06 2.85 0.71 0.04
Female -0.33 -1.06 0.40 0.37 0.37
Non-binary/Self-defined 0.23 -1.68 2.13 0.97 0.81
Age 27.04 -26.43 80.51 27.27 0.32
Age^2 -32.77 -81.83 16.29 25.02 0.19
Mixed or multiple ethnic origins 2.46 0.71 4.21 0.89 0.006
Asian or Asian British 1.73 -1.56 5.02 1.68 0.30
African or African British 2.16 -3.01 7.33 2.64 0.41
Other ethnicity 1.63 -0.87 4.13 1.27 0.20
Key worker -0.36 -0.92 0.20 0.29 0.21
Time difference: Lockdown to baseline 0.04 -0.11 0.18 0.07 0.61
n R2 adjust. R2 F p value df
2391 0.07 0.07 29.22 6.27e-34 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -1.09 -2.60 0.41 0.77 0.15
ocir.sum_score_retro 0.79 0.77 0.82 0.01 0.00e+00
Depressive and anxiety disorder 0.40 -0.54 1.35 0.48 0.40
Only depressive disorder -0.40 -1.66 0.85 0.64 0.53
Only anxiety disorder -0.64 -1.97 0.70 0.68 0.35
Eating disorders 0.64 -0.19 1.46 0.42 0.13
OCDs 1.24 0.50 1.98 0.38 0.001
Psychotic and bipolar disorder 1.76 -0.35 3.87 1.08 0.10
Only psychotic disorder 0.75 -0.94 2.44 0.86 0.39
Only bipolar disorder 0.51 -0.68 1.71 0.61 0.40
PTSD -0.01 -0.73 0.72 0.37 0.98
ASD 1.31 -0.24 2.87 0.79 0.10
ADHD 1.72 -0.51 3.96 1.14 0.13
Personality disorder -0.10 -1.06 0.85 0.49 0.83
Female -0.59 -1.34 0.16 0.38 0.12
Non-binary/Self-defined -0.48 -2.45 1.49 1.00 0.63
Age 32.90 -22.13 87.93 28.06 0.24
Age^2 -32.01 -82.08 18.07 25.53 0.21
Mixed or multiple ethnic origins 2.44 0.68 4.21 0.90 0.007
Asian or Asian British 0.65 -2.76 4.06 1.74 0.71
African or African British -0.51 -6.16 5.13 2.88 0.86
Other ethnicity 1.70 -0.84 4.24 1.30 0.19
Key worker -0.22 -0.80 0.35 0.29 0.44
Time difference: Lockdown to baseline 0.02 -0.12 0.17 0.07 0.76
n R2 adjust. R2 F p value df
2391 0.07 0.07 29.22 6.27e-34 6

OCIR retro

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -2.83 -6.89 1.22 2.07 0.17
Anxiety disorders -2.22 -6.59 2.15 2.23 0.32
Eating disorders -2.17 -8.85 4.52 3.41 0.53
OCDs -3.45 -8.38 1.49 2.52 0.17
PTSD -5.17 -11.03 0.70 2.99 0.08
Depressive disorders -2.57 -6.64 1.51 2.08 0.22
Bipolar disorders -2.82 -7.04 1.39 2.15 0.19
n R2 adjust. R2 F p value df
1833 0.00 0.00 0.62 0.71 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -3.69 -6.52 -0.87 1.44 0.01
Depressive and anxiety disorder -1.42 -4.27 1.44 1.46 0.33
Only depressive disorder -1.99 -5.10 1.12 1.59 0.21
Only anxiety disorder -2.05 -5.16 1.07 1.59 0.20
Eating disorders 0.14 -0.85 1.12 0.50 0.79
OCDs -0.26 -1.11 0.58 0.43 0.54
Psychotic and bipolar disorder 0.76 -1.82 3.33 1.31 0.56
Only psychotic disorder -0.04 -2.04 1.96 1.02 0.97
Only bipolar disorder -0.26 -1.65 1.13 0.71 0.71
PTSD -0.48 -1.31 0.36 0.43 0.26
ASD -0.16 -1.97 1.65 0.92 0.86
ADHD 1.24 -1.46 3.93 1.37 0.37
Personality disorder -0.75 -1.86 0.36 0.57 0.18
n R2 adjust. R2 F p value df
1833 0.00 0.00 0.62 0.71 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -3.49 -7.92 0.93 2.26 0.12
Anxiety disorders -2.31 -6.67 2.05 2.22 0.30
Eating disorders -2.07 -8.75 4.62 3.41 0.54
OCDs -3.38 -8.31 1.54 2.51 0.18
PTSD -5.32 -11.19 0.56 3.00 0.08
Depressive disorders -2.85 -6.93 1.23 2.08 0.17
Bipolar disorders -3.28 -7.50 0.95 2.15 0.13
Female -0.46 -1.41 0.50 0.49 0.35
Non-binary/Self-defined -0.20 -2.48 2.07 1.16 0.86
age_category_collapsed_reordered16-18 0.31 -2.13 2.74 1.24 0.81
19-25 years -0.47 -1.60 0.67 0.58 0.42
36-45 years 1.19 0.19 2.19 0.51 0.02
46-55 years 0.98 0.00 1.96 0.50 0.05
56-65 years 1.23 0.12 2.35 0.57 0.03
66-70 years 2.37 0.14 4.61 1.14 0.04
71-75 years 3.06 -0.17 6.28 1.64 0.06
76+ years 2.11 -4.93 9.14 3.59 0.56
Mixed or multiple ethnic origins 2.32 0.22 4.42 1.07 0.03
Asian or Asian British 0.14 -4.10 4.38 2.16 0.95
African or African British 2.38 -3.90 8.66 3.20 0.46
Other ethnicity 1.30 -1.47 4.08 1.42 0.36
Time difference: Lockdown to baseline 0.08 -0.12 0.28 0.10 0.44
n R2 adjust. R2 F p value df
1833 0.00 0.00 0.62 0.71 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -4.07 -7.52 -0.62 1.76 0.02
Depressive and anxiety disorder -1.65 -4.57 1.28 1.49 0.27
Only depressive disorder -2.52 -5.69 0.66 1.62 0.12
Only anxiety disorder -2.13 -5.29 1.03 1.61 0.19
Eating disorders 0.38 -0.61 1.37 0.51 0.45
OCDs -0.15 -1.00 0.70 0.43 0.72
Psychotic and bipolar disorder 0.36 -2.21 2.94 1.31 0.78
Only psychotic disorder -0.37 -2.38 1.63 1.02 0.71
Only bipolar disorder -0.32 -1.72 1.08 0.72 0.66
PTSD -0.46 -1.30 0.39 0.43 0.29
ASD -0.06 -1.88 1.76 0.93 0.95
ADHD 1.36 -1.36 4.07 1.38 0.33
Personality disorder -0.74 -1.85 0.37 0.57 0.19
Female -0.76 -1.76 0.24 0.51 0.14
Non-binary/Self-defined -0.82 -3.21 1.57 1.22 0.50
age_category_collapsed_reordered16-18 0.51 -1.94 2.95 1.25 0.69
19-25 years -0.49 -1.65 0.68 0.59 0.41
36-45 years 1.25 0.22 2.29 0.53 0.02
46-55 years 0.96 -0.06 1.97 0.52 0.06
56-65 years 1.09 -0.07 2.25 0.59 0.07
66-70 years 2.26 -0.03 4.56 1.17 0.05
71-75 years 2.89 -0.36 6.15 1.66 0.08
76+ years 0.91 -7.26 9.09 4.17 0.83
Mixed or multiple ethnic origins 2.45 0.27 4.63 1.11 0.03
Asian or Asian British -1.13 -5.85 3.58 2.40 0.64
African or African British -0.51 -7.55 6.53 3.59 0.89
Other ethnicity 1.67 -1.24 4.57 1.48 0.26
Key worker 0.11 -0.60 0.83 0.37 0.75
Time difference: Lockdown to baseline 0.07 -0.14 0.27 0.11 0.54
n R2 adjust. R2 F p value df
1833 0.00 0.00 0.62 0.71 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.58 -2.26 5.41 1.95 0.42
ocir.sum_score_retro 0.80 0.78 0.83 0.01 0.00e+00
Anxiety disorders -3.74 -7.83 0.35 2.08 0.07
Eating disorders -2.66 -8.91 3.60 3.19 0.41
OCDs -2.11 -6.73 2.51 2.36 0.37
PTSD -4.34 -9.82 1.15 2.80 0.12
Depressive disorders -2.66 -6.47 1.15 1.94 0.17
Bipolar disorders -1.92 -5.87 2.02 2.01 0.34
n R2 adjust. R2 F p value df
1833 0.71 0.71 644.81 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.14 -1.55 3.83 1.37 0.41
ocir.sum_score_retro 0.78 0.76 0.81 0.01 0.00e+00
Depressive and anxiety disorder -2.11 -4.77 0.55 1.35 0.12
Only depressive disorder -3.03 -5.93 -0.14 1.48 0.04
Only anxiety disorder -3.28 -6.18 -0.39 1.48 0.03
Eating disorders 0.29 -0.63 1.21 0.47 0.53
OCDs 1.45 0.63 2.26 0.41 5.00e-04
Psychotic and bipolar disorder 1.84 -0.56 4.24 1.22 0.13
Only psychotic disorder 0.37 -1.49 2.23 0.95 0.70
Only bipolar disorder 0.39 -0.91 1.68 0.66 0.56
PTSD 0.06 -0.72 0.84 0.40 0.87
ASD 1.15 -0.54 2.84 0.86 0.18
ADHD 1.06 -1.45 3.57 1.28 0.41
Personality disorder 0.25 -0.78 1.29 0.53 0.63
n R2 adjust. R2 F p value df
1837 0.03 0.03 8.98 1.08e-09 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.42 -2.94 5.77 2.22 0.52
ocir.sum_score_retro 0.80 0.78 0.83 0.01 0.00e+00
Anxiety disorders -4.65 -8.89 -0.41 2.16 0.03
Eating disorders -3.27 -9.62 3.09 3.24 0.31
OCDs -2.94 -7.68 1.81 2.42 0.22
PTSD -5.14 -10.76 0.47 2.86 0.07
Depressive disorders -3.68 -7.67 0.31 2.03 0.07
Bipolar disorders -2.92 -7.05 1.20 2.10 0.16
Female -0.34 -1.23 0.55 0.46 0.46
Non-binary/Self-defined 0.23 -1.90 2.36 1.09 0.84
age_category_collapsed_reordered16-18 0.87 -1.40 3.15 1.16 0.45
19-25 years -0.27 -1.33 0.80 0.54 0.62
36-45 years 0.78 -0.16 1.72 0.48 0.10
46-55 years 0.86 -0.06 1.77 0.47 0.07
56-65 years 0.73 -0.32 1.78 0.53 0.17
66-70 years 1.36 -0.75 3.47 1.07 0.21
71-75 years 0.92 -2.11 3.95 1.54 0.55
76+ years 1.61 -4.97 8.18 3.35 0.63
Mixed or multiple ethnic origins 1.96 -0.05 3.97 1.02 0.06
Asian or Asian British 2.24 -1.73 6.21 2.03 0.27
African or African British 3.24 -2.63 9.11 2.99 0.28
Other ethnicity 1.90 -0.75 4.54 1.35 0.16
Key worker -0.41 -1.05 0.24 0.33 0.22
Time difference: Lockdown to baseline 0.15 -0.04 0.34 0.10 0.13
n R2 adjust. R2 F p value df
1837 0.03 0.03 8.98 1.08e-09 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.33 -2.93 3.58 1.66 0.84
ocir.sum_score_retro 0.78 0.76 0.81 0.01 0.00e+00
Depressive and anxiety disorder -2.31 -5.03 0.41 1.39 0.10
Only depressive disorder -3.37 -6.33 -0.42 1.51 0.03
Only anxiety disorder -3.39 -6.33 -0.44 1.50 0.02
Eating disorders 0.47 -0.45 1.40 0.47 0.31
OCDs 1.51 0.70 2.33 0.42 2.85e-04
Psychotic and bipolar disorder 1.51 -0.90 3.91 1.22 0.22
Only psychotic disorder 0.06 -1.81 1.93 0.95 0.95
Only bipolar disorder 0.37 -0.94 1.68 0.67 0.58
PTSD 0.05 -0.74 0.84 0.40 0.91
ASD 1.08 -0.63 2.78 0.87 0.22
ADHD 1.06 -1.47 3.58 1.29 0.41
Personality disorder 0.20 -0.84 1.24 0.53 0.70
Female -0.72 -1.65 0.22 0.48 0.13
Non-binary/Self-defined -0.42 -2.64 1.81 1.13 0.71
age_category_collapsed_reordered16-18 1.13 -1.15 3.42 1.16 0.33
19-25 years -0.16 -1.24 0.93 0.55 0.77
36-45 years 0.91 -0.06 1.87 0.49 0.07
46-55 years 1.03 0.09 1.98 0.48 0.03
56-65 years 0.74 -0.34 1.82 0.55 0.18
66-70 years 1.58 -0.55 3.72 1.09 0.15
71-75 years 1.46 -1.57 4.50 1.55 0.34
76+ years 0.83 -6.78 8.44 3.88 0.83
Mixed or multiple ethnic origins 1.94 -0.09 3.97 1.03 0.06
Asian or Asian British 1.47 -2.93 5.87 2.24 0.51
African or African British 0.05 -6.50 6.60 3.34 0.99
Other ethnicity 1.93 -0.77 4.63 1.38 0.16
Key worker -0.24 -0.91 0.43 0.34 0.48
Time difference: Lockdown to baseline 0.15 -0.05 0.34 0.10 0.14
n R2 adjust. R2 F p value df
1837 0.03 0.03 8.98 1.08e-09 6

PCL baseline, not controlling for prior symptoms

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.44 8.35 8.54 0.05 0.00e+00
Anxiety disorders 3.49 3.24 3.74 0.13 9.52e-163
Eating disorders 3.57 2.77 4.37 0.41 2.26e-18
OCDs 5.56 4.91 6.20 0.33 3.78e-63
PTSD 6.26 5.62 6.89 0.32 7.90e-83
Depressive disorders 6.41 6.29 6.53 0.06 0.00e+00
Bipolar disorders 8.85 8.54 9.16 0.16 0.00e+00
n R2 adjust. R2 F p value df
32567 0.27 0.27 1987.28 0.00e+00 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.65 8.57 8.74 0.04 0.00e+00
Depressive and anxiety disorder 6.11 5.98 6.24 0.07 0.00e+00
Only depressive disorder 2.78 2.61 2.95 0.09 1.85e-216
Only anxiety disorder 3.28 3.06 3.50 0.11 6.19e-185
Eating disorders 1.34 1.11 1.57 0.12 5.16e-30
OCDs 1.74 1.52 1.97 0.11 1.82e-53
Psychotic and bipolar disorder 1.21 0.59 1.84 0.32 1.50e-04
Only psychotic disorder 0.72 0.19 1.26 0.27 0.008
Only bipolar disorder 1.16 0.82 1.50 0.17 1.61e-11
PTSD 2.86 2.65 3.06 0.10 7.16e-163
ASD 1.99 1.59 2.39 0.20 2.03e-22
ADHD 1.21 0.67 1.74 0.27 9.18e-06
Personality disorder 2.82 2.52 3.11 0.15 4.00e-78
n R2 adjust. R2 F p value df
32567 0.27 0.27 1987.28 0.00e+00 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.89 9.61 10.18 0.15 0.00e+00
Anxiety disorders 2.43 2.17 2.69 0.13 1.77e-75
Eating disorders 2.12 1.33 2.92 0.41 1.87e-07
OCDs 3.29 2.64 3.94 0.33 2.58e-23
PTSD 5.39 4.75 6.03 0.33 1.62e-60
Depressive disorders 5.34 5.20 5.47 0.07 0.00e+00
Bipolar disorders 7.67 7.36 7.98 0.16 0.00e+00
Female 0.77 0.63 0.91 0.07 1.06e-27
Non-binary/Self-defined 2.17 1.62 2.72 0.28 8.12e-15
age_category_collapsed_reordered16-18 3.72 3.36 4.09 0.19 8.37e-87
19-25 years 1.86 1.61 2.12 0.13 5.42e-47
36-45 years -0.73 -0.94 -0.52 0.11 1.10e-11
46-55 years -1.26 -1.45 -1.06 0.10 1.82e-36
56-65 years -2.17 -2.36 -1.97 0.10 1.37e-105
66-70 years -2.89 -3.14 -2.64 0.13 4.60e-115
71-75 years -3.05 -3.33 -2.76 0.15 9.12e-97
76+ years -2.92 -3.35 -2.49 0.22 6.93e-40
Mixed or multiple ethnic origins 0.56 0.12 1.00 0.22 0.01
Asian or Asian British 0.20 -0.34 0.74 0.28 0.46
African or African British 0.68 -0.30 1.66 0.50 0.17
Other ethnicity 1.02 0.27 1.78 0.38 0.008
Time difference: Lockdown to baseline -0.01 -0.04 0.02 0.01 0.42
n R2 adjust. R2 F p value df
32567 0.27 0.27 1987.28 0.00e+00 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.96 9.68 10.24 0.14 0.00e+00
Depressive and anxiety disorder 5.22 5.08 5.36 0.07 0.00e+00
Only depressive disorder 2.64 2.46 2.82 0.09 5.39e-177
Only anxiety disorder 2.43 2.20 2.66 0.12 6.09e-95
Eating disorders 0.86 0.63 1.09 0.12 1.83e-13
OCDs 1.30 1.08 1.52 0.11 7.18e-31
Psychotic and bipolar disorder 1.44 0.82 2.06 0.32 4.85e-06
Only psychotic disorder 0.77 0.24 1.30 0.27 0.005
Only bipolar disorder 1.25 0.92 1.59 0.17 2.80e-13
PTSD 2.86 2.66 3.07 0.10 7.38e-163
ASD 1.07 0.67 1.47 0.21 1.95e-07
ADHD 0.60 0.07 1.13 0.27 0.03
Personality disorder 2.53 2.24 2.83 0.15 5.50e-64
Female 0.69 0.55 0.82 0.07 6.12e-24
Non-binary/Self-defined 1.20 0.66 1.73 0.27 1.12e-05
age_category_collapsed_reordered16-18 3.78 3.43 4.13 0.18 6.03e-99
19-25 years 1.74 1.49 1.98 0.12 5.45e-44
36-45 years -0.58 -0.79 -0.38 0.10 2.61e-08
46-55 years -0.86 -1.05 -0.67 0.10 1.09e-18
56-65 years -1.62 -1.81 -1.43 0.10 6.72e-62
66-70 years -2.37 -2.62 -2.12 0.13 4.25e-79
71-75 years -2.56 -2.84 -2.28 0.14 3.64e-71
76+ years -2.40 -2.82 -1.98 0.21 2.56e-29
Mixed or multiple ethnic origins 0.52 0.09 0.95 0.22 0.02
Asian or Asian British 0.77 0.26 1.28 0.26 0.003
African or African British 0.63 -0.29 1.56 0.47 0.18
Other ethnicity 0.84 0.10 1.59 0.38 0.03
Key worker -0.55 -0.67 -0.42 0.06 4.00e-18
Time difference: Lockdown to baseline -0.03 -0.05 0.00 0.01 0.07
n R2 adjust. R2 F p value df
32567 0.27 0.27 1987.28 0.00e+00 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.31 6.99 7.63 0.16 0.00e+00
Anxiety disorders 2.44 2.11 2.76 0.16 1.64e-49
Eating disorders 2.32 1.35 3.28 0.49 2.68e-06
OCDs 3.91 3.07 4.75 0.43 8.31e-20
PTSD 5.53 4.62 6.43 0.46 7.52e-33
Depressive disorders 5.73 5.56 5.89 0.08 0.00e+00
Bipolar disorders 7.95 7.60 8.31 0.18 0.00e+00
Female 0.54 0.38 0.69 0.08 1.40e-11
Non-binary/Self-defined 2.05 1.43 2.67 0.32 9.48e-11
Age -233.98 -245.75 -222.21 6.00 1.94e-321
Age^2 36.66 26.02 47.29 5.43 1.47e-11
Mixed or multiple ethnic origins 0.59 0.08 1.10 0.26 0.02
Asian or Asian British 0.61 -0.08 1.29 0.35 0.08
African or African British 0.86 -0.25 1.97 0.57 0.13
Other ethnicity 1.41 0.49 2.33 0.47 0.003
Time difference: Lockdown to baseline 0.13 0.09 0.17 0.02 3.13e-11
n R2 adjust. R2 F p value df
25270 0.31 0.31 1882.63 0.00e+00 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.59 7.28 7.90 0.16 0.00e+00
Depressive and anxiety disorder 5.70 5.53 5.87 0.09 0.00e+00
Only depressive disorder 2.94 2.72 3.15 0.11 4.51e-155
Only anxiety disorder 2.67 2.38 2.95 0.14 5.36e-75
Eating disorders 1.09 0.82 1.35 0.13 6.40e-16
OCDs 1.31 1.06 1.56 0.13 4.24e-24
Psychotic and bipolar disorder 1.06 0.32 1.81 0.38 0.005
Only psychotic disorder 0.44 -0.17 1.04 0.31 0.16
Only bipolar disorder 1.23 0.86 1.60 0.19 6.56e-11
PTSD 2.88 2.65 3.12 0.12 1.83e-125
ASD 1.36 0.88 1.85 0.25 3.67e-08
ADHD 0.64 -0.02 1.29 0.33 0.06
Personality disorder 2.48 2.14 2.81 0.17 5.13e-48
Female 0.41 0.26 0.56 0.08 7.45e-08
Non-binary/Self-defined 0.96 0.36 1.56 0.31 0.002
Age -196.14 -208.00 -184.28 6.05 3.27e-225
Age^2 24.22 13.67 34.77 5.38 6.83e-06
Mixed or multiple ethnic origins 0.46 -0.04 0.95 0.25 0.07
Asian or Asian British 1.05 0.40 1.69 0.33 0.001
African or African British 0.77 -0.28 1.82 0.54 0.15
Other ethnicity 1.08 0.17 1.99 0.46 0.02
Key worker -0.58 -0.72 -0.44 0.07 3.46e-16
Time difference: Lockdown to baseline 0.13 0.09 0.17 0.02 1.19e-11
n R2 adjust. R2 F p value df
25270 0.31 0.31 1882.63 0.00e+00 6

PCL prepan

Regression: Change scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.28 -0.70 1.25 0.50 0.58
Anxiety disorders -0.06 -1.14 1.02 0.55 0.92
Eating disorders -0.66 -2.70 1.37 1.04 0.52
OCDs -0.05 -1.48 1.39 0.73 0.95
PTSD -1.68 -3.33 -0.02 0.84 0.05
Depressive disorders -0.03 -1.01 0.96 0.50 0.96
Bipolar disorders -0.24 -1.29 0.82 0.54 0.66
n R2 adjust. R2 F p value df
11874 0.00 0.00 1.20 0.30 6

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 0.39 -0.31 1.09 0.36 0.27
Depressive and anxiety disorder 0.02 -0.68 0.73 0.36 0.95
Only depressive disorder -0.16 -0.92 0.61 0.39 0.69
Only anxiety disorder -0.21 -1.01 0.59 0.41 0.61
Eating disorders 0.13 -0.21 0.48 0.18 0.45
OCDs -0.08 -0.40 0.24 0.16 0.64
Psychotic and bipolar disorder -0.69 -1.63 0.24 0.48 0.15
Only psychotic disorder -0.03 -0.82 0.75 0.40 0.93
Only bipolar disorder 0.06 -0.41 0.53 0.24 0.79
PTSD -0.89 -1.20 -0.59 0.15 7.68e-09
ASD -0.12 -0.74 0.51 0.32 0.72
ADHD -0.23 -1.09 0.63 0.44 0.60
Personality disorder -0.29 -0.71 0.13 0.22 0.18
n R2 adjust. R2 F p value df
11874 0.00 0.00 1.20 0.30 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.42 -1.55 0.71 0.58 0.47
Anxiety disorders -0.08 -1.16 1.00 0.55 0.89
Eating disorders -0.77 -2.81 1.26 1.04 0.46
OCDs -0.22 -1.65 1.21 0.73 0.76
PTSD -1.69 -3.34 -0.03 0.85 0.05
Depressive disorders 0.03 -0.96 1.01 0.50 0.96
Bipolar disorders -0.07 -1.12 0.98 0.54 0.90
Female 0.57 0.29 0.84 0.14 4.56e-05
Non-binary/Self-defined 0.06 -0.73 0.85 0.40 0.89
age_category_collapsed_reordered16-18 -0.09 -0.77 0.60 0.35 0.81
19-25 years 0.40 0.03 0.76 0.19 0.03
36-45 years -0.41 -0.72 -0.09 0.16 0.01
46-55 years -0.60 -0.91 -0.30 0.16 1.19e-04
56-65 years -0.30 -0.64 0.05 0.18 0.09
66-70 years -0.43 -1.02 0.17 0.31 0.16
71-75 years -0.40 -1.20 0.39 0.40 0.32
76+ years 0.15 -1.32 1.62 0.75 0.84
Mixed or multiple ethnic origins 0.40 -0.31 1.11 0.36 0.27
Asian or Asian British -0.18 -1.36 1.01 0.61 0.77
African or African British -0.94 -2.80 0.92 0.95 0.32
Other ethnicity -0.45 -1.52 0.61 0.54 0.40
Time difference: Lockdown to baseline 0.06 -0.01 0.12 0.03 0.07
n R2 adjust. R2 F p value df
11874 0.00 0.00 1.20 0.30 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.36 -1.28 0.56 0.47 0.44
Depressive and anxiety disorder 0.08 -0.64 0.79 0.36 0.83
Only depressive disorder -0.03 -0.80 0.74 0.39 0.94
Only anxiety disorder -0.23 -1.04 0.57 0.41 0.57
Eating disorders 0.00 -0.34 0.35 0.18 0.99
OCDs -0.11 -0.44 0.21 0.16 0.49
Psychotic and bipolar disorder -0.58 -1.52 0.35 0.48 0.22
Only psychotic disorder 0.07 -0.72 0.86 0.40 0.86
Only bipolar disorder 0.20 -0.27 0.67 0.24 0.41
PTSD -0.87 -1.18 -0.57 0.16 1.90e-08
ASD -0.12 -0.75 0.52 0.32 0.72
ADHD -0.22 -1.08 0.64 0.44 0.62
Personality disorder -0.44 -0.86 -0.01 0.22 0.04
Female 0.69 0.40 0.98 0.15 3.50e-06
Non-binary/Self-defined 0.17 -0.65 0.99 0.42 0.68
age_category_collapsed_reordered16-18 -0.17 -0.85 0.51 0.35 0.62
19-25 years 0.30 -0.07 0.67 0.19 0.12
36-45 years -0.45 -0.78 -0.13 0.17 0.007
46-55 years -0.55 -0.87 -0.23 0.16 8.29e-04
56-65 years -0.33 -0.69 0.04 0.18 0.08
66-70 years -0.63 -1.26 0.01 0.32 0.05
71-75 years -0.65 -1.49 0.19 0.43 0.13
76+ years 0.11 -1.51 1.74 0.83 0.89
Mixed or multiple ethnic origins 0.45 -0.29 1.19 0.38 0.24
Asian or Asian British 0.22 -1.00 1.45 0.63 0.72
African or African British -1.19 -3.10 0.72 0.97 0.22
Other ethnicity 0.11 -1.01 1.22 0.57 0.85
Key worker -0.21 -0.44 0.01 0.11 0.06
Time difference: Lockdown to baseline 0.07 0.00 0.13 0.03 0.04
n R2 adjust. R2 F p value df
11874 0.00 0.00 1.20 0.30 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.66 -1.77 0.44 0.57 0.24
Anxiety disorders -0.07 -1.15 1.01 0.55 0.90
Eating disorders -0.83 -2.86 1.20 1.04 0.42
OCDs -0.24 -1.67 1.19 0.73 0.74
PTSD -1.68 -3.34 -0.02 0.85 0.05
Depressive disorders 0.04 -0.94 1.03 0.50 0.93
Bipolar disorders -0.06 -1.11 0.99 0.54 0.91
Female 0.57 0.30 0.85 0.14 3.74e-05
Non-binary/Self-defined 0.07 -0.72 0.86 0.40 0.87
Age -25.83 -37.44 -14.22 5.92 1.31e-05
Age^2 17.47 6.11 28.84 5.80 0.003
Mixed or multiple ethnic origins 0.39 -0.31 1.10 0.36 0.28
Asian or Asian British -0.19 -1.38 0.99 0.61 0.75
African or African British -0.95 -2.81 0.91 0.95 0.32
Other ethnicity -0.46 -1.53 0.61 0.54 0.40
Time difference: Lockdown to baseline 0.06 -0.01 0.12 0.03 0.08
n R2 adjust. R2 F p value df
11874 0.00 0.00 1.20 0.30 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept -0.66 -1.55 0.23 0.45 0.15
Depressive and anxiety disorder 0.11 -0.60 0.82 0.36 0.76
Only depressive disorder 0.00 -0.77 0.77 0.39 1.00
Only anxiety disorder -0.21 -1.01 0.60 0.41 0.61
Eating disorders 0.00 -0.35 0.34 0.18 0.99
OCDs -0.12 -0.44 0.21 0.16 0.48
Psychotic and bipolar disorder -0.57 -1.51 0.37 0.48 0.23
Only psychotic disorder 0.05 -0.73 0.84 0.40 0.90
Only bipolar disorder 0.19 -0.28 0.67 0.24 0.42
PTSD -0.88 -1.19 -0.58 0.16 1.42e-08
ASD -0.15 -0.78 0.48 0.32 0.64
ADHD -0.23 -1.09 0.63 0.44 0.60
Personality disorder -0.42 -0.85 0.00 0.22 0.05
Female 0.69 0.40 0.98 0.15 2.71e-06
Non-binary/Self-defined 0.19 -0.63 1.01 0.42 0.65
Age -25.48 -37.77 -13.20 6.27 4.80e-05
Age^2 11.30 -0.94 23.54 6.25 0.07
Mixed or multiple ethnic origins 0.45 -0.30 1.19 0.38 0.24
Asian or Asian British 0.21 -1.02 1.43 0.63 0.74
African or African British -1.20 -3.11 0.71 0.97 0.22
Other ethnicity 0.10 -1.02 1.21 0.57 0.87
Key worker -0.21 -0.43 0.01 0.11 0.07
Time difference: Lockdown to baseline 0.07 0.00 0.13 0.03 0.04
n R2 adjust. R2 F p value df
11874 0.00 0.00 1.20 0.30 6

Regression: Absolute scores

Model 0a: Disorder_hierarchical, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.09 5.20 6.98 0.45 1.24e-40
pcl.sum_score_prepan 0.57 0.55 0.58 0.01 0.00e+00
Anxiety disorders -0.32 -1.28 0.64 0.49 0.51
Eating disorders -0.18 -1.99 1.63 0.92 0.85
OCDs 0.51 -0.76 1.79 0.65 0.43
PTSD 0.03 -1.43 1.50 0.75 0.97
Depressive disorders 0.87 -0.01 1.74 0.45 0.05
Bipolar disorders 1.40 0.47 2.34 0.48 0.003
n R2 adjust. R2 F p value df
11874 0.33 0.32 817.59 0.00e+00 7

Model 0b: Overlapping disorders, Unadjusted

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.83 6.17 7.48 0.33 7.35e-91
pcl.sum_score_prepan 0.53 0.52 0.55 0.01 0.00e+00
Depressive and anxiety disorder 0.51 -0.12 1.13 0.32 0.11
Only depressive disorder -0.51 -1.19 0.16 0.34 0.14
Only anxiety disorder -0.63 -1.34 0.08 0.36 0.08
Eating disorders 0.59 0.29 0.89 0.16 1.40e-04
OCDs 0.61 0.33 0.90 0.15 2.59e-05
Psychotic and bipolar disorder -0.40 -1.23 0.42 0.42 0.34
Only psychotic disorder -0.05 -0.74 0.65 0.35 0.89
Only bipolar disorder 0.35 -0.07 0.76 0.21 0.10
PTSD 0.73 0.46 1.01 0.14 1.43e-07
ASD 0.65 0.10 1.20 0.28 0.02
ADHD 0.24 -0.51 1.00 0.39 0.53
Personality disorder 1.08 0.71 1.46 0.19 1.71e-08
n R2 adjust. R2 F p value df
11940 0.01 0.01 30.02 6.05e-36 6

Model 1a: Disorder hierarchical, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.79 4.77 6.81 0.52 1.43e-28
pcl.sum_score_prepan 0.54 0.52 0.55 0.01 0.00e+00
Anxiety disorders -0.35 -1.30 0.60 0.48 0.47
Eating disorders -0.23 -2.01 1.56 0.91 0.80
OCDs 0.22 -1.04 1.48 0.64 0.73
PTSD 0.40 -1.06 1.86 0.74 0.59
Depressive disorders 1.08 0.21 1.94 0.44 0.02
Bipolar disorders 1.75 0.82 2.68 0.47 2.27e-04
Female 0.57 0.33 0.81 0.12 2.94e-06
Non-binary/Self-defined 0.84 0.15 1.54 0.35 0.02
age_category_collapsed_reordered16-18 1.07 0.47 1.68 0.31 4.75e-04
19-25 years 0.89 0.57 1.21 0.16 5.85e-08
36-45 years -0.47 -0.74 -0.19 0.14 9.59e-04
46-55 years -0.70 -0.97 -0.43 0.14 3.17e-07
56-65 years -0.97 -1.28 -0.67 0.16 3.99e-10
66-70 years -1.99 -2.53 -1.46 0.27 2.90e-13
71-75 years -2.37 -3.07 -1.67 0.36 4.06e-11
76+ years -2.21 -3.50 -0.92 0.66 7.85e-04
Mixed or multiple ethnic origins 0.33 -0.29 0.96 0.32 0.30
Asian or Asian British 0.15 -0.90 1.19 0.53 0.79
African or African British 0.06 -1.57 1.69 0.83 0.94
Other ethnicity 0.16 -0.78 1.10 0.48 0.73
Key worker -0.66 -0.85 -0.47 0.10 7.14e-12
Time difference: Lockdown to baseline 0.09 0.04 0.15 0.03 9.23e-04
n R2 adjust. R2 F p value df
11940 0.01 0.01 30.02 6.05e-36 6

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed_reordered + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.46 5.62 7.30 0.43 5.67e-51
pcl.sum_score_prepan 0.51 0.50 0.53 0.01 0.00e+00
Depressive and anxiety disorder 0.70 0.07 1.32 0.32 0.03
Only depressive disorder -0.13 -0.80 0.55 0.34 0.71
Only anxiety disorder -0.64 -1.35 0.06 0.36 0.07
Eating disorders 0.43 0.12 0.73 0.15 0.006
OCDs 0.52 0.23 0.80 0.14 3.53e-04
Psychotic and bipolar disorder -0.19 -1.01 0.63 0.42 0.65
Only psychotic disorder 0.04 -0.65 0.72 0.35 0.92
Only bipolar disorder 0.51 0.10 0.93 0.21 0.01
PTSD 0.85 0.57 1.12 0.14 1.20e-09
ASD 0.37 -0.19 0.92 0.28 0.19
ADHD 0.16 -0.59 0.91 0.38 0.68
Personality disorder 0.92 0.55 1.30 0.19 1.43e-06
Female 0.47 0.21 0.72 0.13 3.21e-04
Non-binary/Self-defined 0.47 -0.25 1.18 0.36 0.20
age_category_collapsed_reordered16-18 1.18 0.58 1.78 0.31 1.12e-04
19-25 years 0.87 0.54 1.19 0.17 2.18e-07
36-45 years -0.48 -0.77 -0.19 0.15 0.001
46-55 years -0.57 -0.85 -0.29 0.14 6.43e-05
56-65 years -0.78 -1.10 -0.46 0.16 1.33e-06
66-70 years -1.84 -2.39 -1.28 0.28 8.75e-11
71-75 years -2.22 -2.95 -1.48 0.38 3.86e-09
76+ years -1.76 -3.19 -0.34 0.73 0.02
Mixed or multiple ethnic origins 0.24 -0.41 0.89 0.33 0.47
Asian or Asian British 0.52 -0.55 1.60 0.55 0.34
African or African British -0.02 -1.69 1.65 0.85 0.98
Other ethnicity 0.35 -0.63 1.32 0.50 0.49
Key worker -0.59 -0.79 -0.40 0.10 2.64e-09
Time difference: Lockdown to baseline 0.09 0.04 0.15 0.03 0.001
n R2 adjust. R2 F p value df
11940 0.01 0.01 30.02 6.05e-36 6

Model 2a: Disorder hierarchical, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.43 4.43 6.43 0.51 2.81e-26
pcl.sum_score_prepan 0.54 0.53 0.56 0.01 0.00e+00
Anxiety disorders -0.37 -1.32 0.58 0.48 0.45
Eating disorders -0.30 -2.09 1.48 0.91 0.74
OCDs 0.22 -1.04 1.48 0.64 0.73
PTSD 0.31 -1.14 1.77 0.74 0.67
Depressive disorders 1.04 0.17 1.91 0.44 0.02
Bipolar disorders 1.70 0.77 2.63 0.47 3.51e-04
Female 0.56 0.32 0.80 0.12 4.16e-06
Non-binary/Self-defined 0.85 0.16 1.54 0.35 0.02
Age -79.27 -89.66 -68.88 5.30 3.91e-50
Age^2 2.83 -7.45 13.10 5.24 0.59
Mixed or multiple ethnic origins 0.31 -0.31 0.94 0.32 0.33
Asian or Asian British 0.15 -0.90 1.19 0.53 0.78
African or African British 0.05 -1.58 1.68 0.83 0.95
Other ethnicity 0.17 -0.77 1.11 0.48 0.72
Key worker -0.67 -0.86 -0.48 0.10 3.99e-12
Time difference: Lockdown to baseline 0.10 0.04 0.15 0.03 8.12e-04
n R2 adjust. R2 F p value df
11940 0.01 0.01 30.02 6.05e-36 6

Model 2b: Overlapping disorders, Adjusted with age^2

Model 0a + Gender_collapsed + age^2 + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.14 5.33 6.96 0.41 2.72e-49
pcl.sum_score_prepan 0.51 0.50 0.53 0.01 0.00e+00
Depressive and anxiety disorder 0.66 0.03 1.28 0.32 0.04
Only depressive disorder -0.14 -0.82 0.53 0.34 0.68
Only anxiety disorder -0.67 -1.37 0.04 0.36 0.06
Eating disorders 0.43 0.13 0.74 0.15 0.005
OCDs 0.51 0.23 0.79 0.14 4.12e-04
Psychotic and bipolar disorder -0.17 -0.99 0.66 0.42 0.69
Only psychotic disorder 0.04 -0.65 0.72 0.35 0.92
Only bipolar disorder 0.50 0.09 0.91 0.21 0.02
PTSD 0.85 0.57 1.12 0.14 1.17e-09
ASD 0.39 -0.16 0.94 0.28 0.17
ADHD 0.10 -0.65 0.86 0.38 0.79
Personality disorder 0.88 0.51 1.26 0.19 4.03e-06
Female 0.46 0.21 0.71 0.13 3.88e-04
Non-binary/Self-defined 0.47 -0.24 1.19 0.36 0.19
Age -71.24 -82.10 -60.38 5.54 1.45e-37
Age^2 6.03 -4.69 16.75 5.47 0.27
Mixed or multiple ethnic origins 0.23 -0.42 0.88 0.33 0.50
Asian or Asian British 0.52 -0.56 1.59 0.55 0.35
African or African British -0.03 -1.70 1.64 0.85 0.97
Other ethnicity 0.33 -0.65 1.31 0.50 0.51
Key worker -0.60 -0.79 -0.40 0.10 2.46e-09
Time difference: Lockdown to baseline 0.10 0.04 0.15 0.03 0.001
n R2 adjust. R2 F p value df
11940 0.01 0.01 30.02 6.05e-36 6

SENSITIVITY based on highest level of education

GAD prepan

Regression: Absolute scores

GAD baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.51 6.17 6.85 0.17 4.16e-303
Depressive and anxiety disorder 4.54 4.39 4.68 0.07 0.00e+00
Only depressive disorder 1.83 1.65 2.02 0.10 5.27e-82
Only anxiety disorder 3.05 2.82 3.29 0.12 2.00e-141
Eating disorders 0.92 0.69 1.16 0.12 1.63e-14
OCDs 1.43 1.20 1.65 0.12 9.22e-35
Psychotic and bipolar disorder 0.65 0.01 1.29 0.33 0.05
Only psychotic disorder 0.46 -0.09 1.01 0.28 0.10
Only bipolar disorder 0.62 0.27 0.96 0.18 4.47e-04
PTSD 1.53 1.31 1.74 0.11 1.13e-45
ASD 1.37 0.96 1.78 0.21 7.67e-11
ADHD 0.44 -0.10 0.98 0.28 0.11
Personality disorder 1.69 1.39 1.99 0.15 5.48e-28
Female 0.96 0.82 1.10 0.07 3.16e-42
Non-binary/Self-defined 0.70 0.16 1.24 0.28 0.01
age_category_collapsed_reordered16-18 2.72 2.35 3.09 0.19 6.72e-46
age_category_collapsed_reordered19-25 1.55 1.30 1.80 0.13 3.62e-34
age_category_collapsed_reordered36-45 -0.71 -0.92 -0.50 0.11 2.26e-11
age_category_collapsed_reordered46-55 -1.32 -1.52 -1.13 0.10 6.80e-40
age_category_collapsed_reordered56-65 -2.22 -2.42 -2.03 0.10 1.74e-107
age_category_collapsed_reordered66-70 -3.14 -3.40 -2.89 0.13 9.40e-127
age_category_collapsed_reordered71-75 -3.35 -3.65 -3.06 0.15 1.82e-107
age_category_collapsed_reordered76+ -3.25 -3.70 -2.80 0.23 1.10e-44
Mixed or multiple ethnic origins 0.11 -0.33 0.54 0.22 0.62
Asian or Asian British 0.15 -0.37 0.67 0.26 0.57
African or African British -0.45 -1.40 0.50 0.49 0.35
Other ethnicity 0.93 0.16 1.71 0.39 0.02
Key worker -0.30 -0.43 -0.18 0.06 2.81e-06
Time difference: Lockdown to baseline -0.26 -0.28 -0.23 0.01 1.10e-67
Highest education NVQ -0.45 -0.73 -0.16 0.15 0.002
Highest education A-Levels -0.56 -0.77 -0.35 0.11 1.56e-07
Highest education University -1.00 -1.19 -0.81 0.10 1.10e-25
n R2 adjust. R2 F p value df
32679 0.21 0.21 1485.53 0.00e+00 6

GAD retro

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.05 3.76 4.35 0.15 3.89e-157
gad.sum_score_retro 0.65 0.64 0.66 0.01 0.00e+00
Depressive and anxiety disorder 2.49 2.35 2.63 0.07 2.68e-273
Only depressive disorder 1.07 0.91 1.23 0.08 4.92e-38
Only anxiety disorder 1.82 1.61 2.02 0.10 3.27e-67
Eating disorders 0.49 0.29 0.70 0.10 2.73e-06
OCDs 0.45 0.26 0.65 0.10 7.35e-06
Psychotic and bipolar disorder 0.29 -0.27 0.86 0.29 0.30
Only psychotic disorder 0.18 -0.31 0.67 0.25 0.47
Only bipolar disorder 0.32 0.01 0.62 0.16 0.04
PTSD 0.75 0.57 0.93 0.09 1.41e-15
ASD 0.67 0.31 1.03 0.18 2.49e-04
ADHD 0.12 -0.35 0.59 0.24 0.62
Personality disorder 0.57 0.30 0.83 0.13 2.36e-05
Female 0.81 0.69 0.93 0.06 5.29e-40
Non-binary/Self-defined 0.10 -0.37 0.57 0.24 0.67
age_category_collapsed_reordered16-18 0.83 0.51 1.15 0.16 4.29e-07
age_category_collapsed_reordered19-25 0.92 0.71 1.14 0.11 2.94e-17
age_category_collapsed_reordered36-45 -0.53 -0.71 -0.35 0.09 9.20e-09
age_category_collapsed_reordered46-55 -0.89 -1.06 -0.72 0.09 1.53e-24
age_category_collapsed_reordered56-65 -1.29 -1.46 -1.12 0.09 5.12e-49
age_category_collapsed_reordered66-70 -1.81 -2.04 -1.59 0.11 1.96e-57
age_category_collapsed_reordered71-75 -2.00 -2.26 -1.74 0.13 2.04e-52
age_category_collapsed_reordered76+ -2.07 -2.46 -1.68 0.20 2.21e-25
Mixed or multiple ethnic origins -0.24 -0.61 0.14 0.19 0.21
Asian or Asian British -0.14 -0.58 0.31 0.23 0.55
African or African British -0.68 -1.50 0.13 0.42 0.10
Other ethnicity 0.55 -0.12 1.23 0.34 0.11
Key worker 0.05 -0.06 0.16 0.06 0.38
Time difference: Lockdown to baseline -0.22 -0.24 -0.19 0.01 3.06e-65
Highest education NVQ -0.26 -0.51 -0.01 0.13 0.04
Highest education A-Levels -0.28 -0.46 -0.10 0.09 0.002
Highest education University -0.39 -0.55 -0.23 0.08 2.15e-06
n R2 adjust. R2 F p value df
30973 0.25 0.25 1678.24 0.00e+00 6

GAD prepan

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.10 2.17 4.03 0.47 6.34e-11
pcl.sum_score_prepan 0.36 0.35 0.38 0.01 0.00e+00
Depressive and anxiety disorder 0.93 0.29 1.57 0.33 0.004
Only depressive disorder -0.82 -1.52 -0.13 0.35 0.02
Only anxiety disorder 0.76 0.03 1.48 0.37 0.04
Eating disorders 0.79 0.48 1.11 0.16 6.88e-07
OCDs 0.84 0.55 1.14 0.15 1.68e-08
Psychotic and bipolar disorder -0.32 -1.17 0.53 0.43 0.46
Only psychotic disorder 0.09 -0.62 0.80 0.36 0.81
Only bipolar disorder 0.18 -0.25 0.60 0.22 0.42
PTSD 0.13 -0.15 0.41 0.14 0.36
ASD 0.79 0.22 1.36 0.29 0.007
ADHD -0.04 -0.81 0.73 0.39 0.92
Personality disorder 0.58 0.19 0.96 0.20 0.004
Female 0.54 0.28 0.80 0.13 5.05e-05
Non-binary/Self-defined 0.19 -0.54 0.92 0.37 0.61
age_category_collapsed_reordered16-18 1.04 0.41 1.68 0.32 0.001
age_category_collapsed_reordered19-25 1.00 0.67 1.34 0.17 5.06e-09
age_category_collapsed_reordered36-45 -0.49 -0.79 -0.20 0.15 9.84e-04
age_category_collapsed_reordered46-55 -0.91 -1.20 -0.62 0.15 6.51e-10
age_category_collapsed_reordered56-65 -1.67 -2.00 -1.34 0.17 3.81e-23
age_category_collapsed_reordered66-70 -2.38 -2.96 -1.79 0.30 1.64e-15
age_category_collapsed_reordered71-75 -2.62 -3.41 -1.83 0.40 8.53e-11
age_category_collapsed_reordered76+ -2.32 -3.81 -0.83 0.76 0.002
Mixed or multiple ethnic origins 0.01 -0.65 0.67 0.34 0.98
Asian or Asian British -0.07 -1.17 1.03 0.56 0.90
African or African British -0.90 -2.68 0.87 0.91 0.32
Other ethnicity 0.85 -0.17 1.87 0.52 0.10
Key worker -0.25 -0.45 -0.05 0.10 0.02
Time difference: Lockdown to baseline 0.00 -0.06 0.06 0.03 0.95
Highest education NVQ -0.18 -0.66 0.30 0.24 0.47
Highest education A-Levels -0.90 -1.28 -0.51 0.20 5.25e-06
Highest education University -1.15 -1.51 -0.79 0.18 3.38e-10
n R2 adjust. R2 F p value df
12028 0.00 0.00 8.99 7.92e-10 6

PHQ baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.69 7.31 8.07 0.19 0.00e+00
Depressive and anxiety disorder 5.50 5.33 5.66 0.08 0.00e+00
Only depressive disorder 3.43 3.22 3.64 0.11 7.32e-220
Only anxiety disorder 2.03 1.77 2.30 0.14 5.41e-51
Eating disorders 1.59 1.33 1.86 0.14 6.57e-32
OCDs 1.35 1.10 1.61 0.13 3.69e-25
Psychotic and bipolar disorder 0.45 -0.27 1.18 0.37 0.22
Only psychotic disorder 0.88 0.26 1.49 0.32 0.006
Only bipolar disorder 1.44 1.05 1.83 0.20 3.51e-13
PTSD 2.05 1.82 2.29 0.12 2.33e-64
ASD 1.54 1.08 2.01 0.24 7.69e-11
ADHD 1.01 0.40 1.62 0.31 0.001
Personality disorder 2.86 2.52 3.20 0.17 1.67e-60
Female 0.85 0.69 1.00 0.08 1.16e-26
Non-binary/Self-defined 1.38 0.76 1.99 0.31 1.12e-05
age_category_collapsed_reordered16-18 5.01 4.59 5.43 0.21 3.79e-119
age_category_collapsed_reordered19-25 2.04 1.76 2.32 0.14 7.27e-46
age_category_collapsed_reordered36-45 -0.68 -0.91 -0.44 0.12 1.72e-08
age_category_collapsed_reordered46-55 -1.09 -1.31 -0.87 0.11 3.32e-22
age_category_collapsed_reordered56-65 -2.19 -2.41 -1.97 0.11 1.15e-82
age_category_collapsed_reordered66-70 -3.41 -3.70 -3.13 0.15 3.51e-118
age_category_collapsed_reordered71-75 -3.54 -3.87 -3.20 0.17 1.40e-94
age_category_collapsed_reordered76+ -3.42 -3.93 -2.91 0.26 4.03e-39
Mixed or multiple ethnic origins 0.38 -0.11 0.87 0.25 0.13
Asian or Asian British 0.33 -0.25 0.92 0.30 0.27
African or African British -0.31 -1.39 0.76 0.55 0.57
Other ethnicity 0.99 0.12 1.86 0.45 0.03
Key worker -0.60 -0.74 -0.46 0.07 1.07e-16
Time difference: Lockdown to baseline -0.24 -0.27 -0.21 0.02 1.33e-46
Highest education NVQ -0.70 -1.03 -0.38 0.16 1.71e-05
Highest education A-Levels -0.62 -0.86 -0.39 0.12 2.12e-07
Highest education University -1.44 -1.65 -1.23 0.11 4.70e-41
n R2 adjust. R2 F p value df
32662 0.25 0.25 1854.75 0.00e+00 6

PHQ retro

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.72 4.40 5.04 0.16 9.69e-183
phq.sum_score_retro 0.67 0.66 0.68 0.01 0.00e+00
Depressive and anxiety disorder 2.77 2.62 2.92 0.08 7.05e-290
Only depressive disorder 1.77 1.60 1.95 0.09 4.60e-86
Only anxiety disorder 1.23 1.01 1.45 0.11 3.91e-28
Eating disorders 0.77 0.54 0.99 0.11 1.28e-11
OCDs 0.43 0.22 0.65 0.11 7.11e-05
Psychotic and bipolar disorder -0.15 -0.76 0.45 0.31 0.62
Only psychotic disorder 0.12 -0.40 0.65 0.27 0.65
Only bipolar disorder 0.66 0.33 0.99 0.17 8.34e-05
PTSD 1.00 0.80 1.20 0.10 5.44e-23
ASD 0.69 0.31 1.08 0.20 4.55e-04
ADHD 0.25 -0.26 0.76 0.26 0.33
Personality disorder 0.95 0.67 1.24 0.14 4.46e-11
Female 0.74 0.61 0.86 0.07 3.04e-29
Non-binary/Self-defined 0.48 -0.02 0.98 0.26 0.06
age_category_collapsed_reordered16-18 2.68 2.34 3.03 0.18 6.00e-52
age_category_collapsed_reordered19-25 1.22 0.99 1.45 0.12 2.12e-25
age_category_collapsed_reordered36-45 -0.56 -0.76 -0.37 0.10 1.82e-08
age_category_collapsed_reordered46-55 -0.79 -0.97 -0.61 0.09 2.25e-17
age_category_collapsed_reordered56-65 -1.33 -1.51 -1.14 0.09 5.52e-45
age_category_collapsed_reordered66-70 -1.92 -2.16 -1.68 0.12 8.36e-56
age_category_collapsed_reordered71-75 -2.07 -2.34 -1.79 0.14 3.34e-48
age_category_collapsed_reordered76+ -2.10 -2.52 -1.68 0.22 1.64e-22
Mixed or multiple ethnic origins 0.05 -0.35 0.46 0.20 0.79
Asian or Asian British -0.02 -0.49 0.46 0.24 0.95
African or African British -0.46 -1.34 0.41 0.45 0.30
Other ethnicity 0.36 -0.36 1.09 0.37 0.33
Key worker -0.05 -0.17 0.07 0.06 0.40
Time difference: Lockdown to baseline -0.22 -0.25 -0.19 0.01 2.64e-58
Highest education NVQ -0.42 -0.69 -0.15 0.14 0.002
Highest education A-Levels -0.31 -0.50 -0.12 0.10 0.002
Highest education University -0.57 -0.74 -0.39 0.09 1.72e-10
n R2 adjust. R2 F p value df
30959 0.28 0.28 2029.98 0.00e+00 6

PHQ prepan

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.09 3.05 5.12 0.53 1.05e-14
pcl.sum_score_prepan 0.43 0.41 0.45 0.01 0.00e+00
Depressive and anxiety disorder 1.17 0.45 1.88 0.36 0.001
Only depressive disorder 1.00 0.23 1.78 0.39 0.01
Only anxiety disorder -1.07 -1.88 -0.27 0.41 0.009
Eating disorders 1.41 1.06 1.76 0.18 2.67e-15
OCDs 0.71 0.38 1.03 0.17 2.23e-05
Psychotic and bipolar disorder -0.57 -1.52 0.38 0.48 0.24
Only psychotic disorder 0.38 -0.41 1.18 0.41 0.34
Only bipolar disorder 0.76 0.29 1.23 0.24 0.002
PTSD 0.18 -0.14 0.49 0.16 0.27
ASD 0.74 0.10 1.38 0.33 0.02
ADHD 0.14 -0.72 1.00 0.44 0.75
Personality disorder 1.37 0.93 1.80 0.22 5.87e-10
Female 0.12 -0.17 0.41 0.15 0.41
Non-binary/Self-defined 0.53 -0.28 1.35 0.42 0.20
age_category_collapsed_reordered16-18 2.39 1.68 3.10 0.36 3.66e-11
age_category_collapsed_reordered19-25 1.32 0.95 1.69 0.19 4.80e-12
age_category_collapsed_reordered36-45 -0.44 -0.77 -0.11 0.17 0.008
age_category_collapsed_reordered46-55 -0.60 -0.92 -0.28 0.16 2.76e-04
age_category_collapsed_reordered56-65 -1.46 -1.83 -1.10 0.19 6.73e-15
age_category_collapsed_reordered66-70 -2.91 -3.56 -2.26 0.33 2.14e-18
age_category_collapsed_reordered71-75 -3.22 -4.10 -2.34 0.45 6.95e-13
age_category_collapsed_reordered76+ -2.65 -4.33 -0.97 0.86 0.002
Mixed or multiple ethnic origins 0.37 -0.37 1.10 0.38 0.33
Asian or Asian British -0.06 -1.29 1.16 0.62 0.92
African or African British -0.71 -2.69 1.27 1.01 0.48
Other ethnicity 0.45 -0.68 1.59 0.58 0.44
Key worker -0.72 -0.94 -0.49 0.11 3.85e-10
Time difference: Lockdown to baseline 0.05 -0.02 0.11 0.03 0.16
Highest education NVQ -0.24 -0.78 0.29 0.27 0.38
Highest education A-Levels -0.96 -1.39 -0.53 0.22 1.33e-05
Highest education University -1.56 -1.96 -1.16 0.20 2.42e-14
n R2 adjust. R2 F p value df
12024 0.02 0.02 41.62 1.65e-50 6

OCIR baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 18.75 16.87 20.63 0.96 4.94e-82
Depressive and anxiety disorder 3.14 2.24 4.04 0.46 1.13e-11
Only depressive disorder 0.36 -0.85 1.57 0.62 0.56
Only anxiety disorder 0.82 -0.43 2.06 0.64 0.20
Eating disorders 0.37 -0.70 1.44 0.54 0.50
OCDs 7.03 6.09 7.97 0.48 9.11e-48
Psychotic and bipolar disorder 7.05 4.47 9.62 1.32 8.91e-08
Only psychotic disorder 4.27 1.97 6.57 1.17 2.73e-04
Only bipolar disorder 2.81 1.15 4.47 0.85 8.89e-04
PTSD 2.07 1.14 3.01 0.48 1.41e-05
ASD 7.45 5.74 9.17 0.87 1.75e-17
ADHD 2.35 0.01 4.69 1.19 0.05
Personality disorder 2.85 1.57 4.13 0.65 1.24e-05
Female -0.88 -1.81 0.04 0.47 0.06
Non-binary/Self-defined -1.03 -3.53 1.47 1.27 0.42
age_category_collapsed_reordered16-18 6.38 4.71 8.05 0.85 7.40e-14
age_category_collapsed_reordered19-25 1.52 0.29 2.75 0.63 0.02
age_category_collapsed_reordered36-45 -0.14 -1.29 1.02 0.59 0.82
age_category_collapsed_reordered46-55 -0.26 -1.33 0.81 0.55 0.63
age_category_collapsed_reordered56-65 -1.36 -2.44 -0.27 0.55 0.01
age_category_collapsed_reordered66-70 -1.33 -2.94 0.29 0.82 0.11
age_category_collapsed_reordered71-75 -2.33 -4.33 -0.34 1.02 0.02
age_category_collapsed_reordered76+ -3.89 -7.58 -0.19 1.89 0.04
Mixed or multiple ethnic origins 0.66 -1.54 2.85 1.12 0.56
Asian or Asian British 5.40 2.54 8.27 1.46 2.16e-04
African or African British 1.20 -4.67 7.08 3.00 0.69
Other ethnicity 2.84 -0.30 5.98 1.60 0.08
Key worker -0.81 -1.52 -0.10 0.36 0.02
Time difference: Lockdown to baseline -0.44 -0.59 -0.29 0.08 2.58e-08
Highest education NVQ -1.05 -2.97 0.88 0.98 0.29
Highest education A-Levels -2.06 -3.15 -0.96 0.56 2.46e-04
Highest education University -3.17 -4.19 -2.14 0.52 1.34e-09
n R2 adjust. R2 F p value df
5506 0.05 0.05 52.82 1.41e-63 6

OCIR retro

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 14.27 12.75 15.78 0.77 8.64e-73
ocir.sum_score_retro 0.74 0.72 0.77 0.01 0.00e+00
Depressive and anxiety disorder -1.20 -1.94 -0.46 0.38 0.001
Only depressive disorder -0.91 -1.90 0.08 0.51 0.07
Only anxiety disorder -0.39 -1.41 0.62 0.52 0.45
Eating disorders -0.11 -0.94 0.73 0.43 0.80
OCDs 2.16 1.42 2.90 0.38 1.19e-08
Psychotic and bipolar disorder 4.15 2.14 6.16 1.03 5.37e-05
Only psychotic disorder 1.49 -0.28 3.25 0.90 0.10
Only bipolar disorder 0.43 -0.81 1.68 0.63 0.50
PTSD 0.62 -0.10 1.34 0.37 0.09
ASD 2.43 1.06 3.79 0.70 5.04e-04
ADHD 1.74 -0.14 3.62 0.96 0.07
Personality disorder 0.66 -0.31 1.64 0.50 0.18
Female 0.10 -0.63 0.83 0.37 0.79
Non-binary/Self-defined -0.58 -2.54 1.38 1.00 0.56
age_category_collapsed_reordered16-18 4.44 3.03 5.85 0.72 6.98e-10
age_category_collapsed_reordered19-25 0.14 -0.83 1.11 0.49 0.77
age_category_collapsed_reordered36-45 0.21 -0.67 1.10 0.45 0.64
age_category_collapsed_reordered46-55 0.24 -0.59 1.07 0.42 0.57
age_category_collapsed_reordered56-65 0.98 0.13 1.84 0.44 0.02
age_category_collapsed_reordered66-70 1.31 0.03 2.60 0.66 0.05
age_category_collapsed_reordered71-75 1.02 -0.60 2.64 0.83 0.22
age_category_collapsed_reordered76+ -1.84 -5.23 1.56 1.73 0.29
Mixed or multiple ethnic origins 1.20 -0.51 2.90 0.87 0.17
Asian or Asian British 3.60 1.15 6.05 1.25 0.004
African or African British -1.12 -6.03 3.80 2.51 0.66
Other ethnicity 0.54 -1.83 2.90 1.21 0.66
Key worker -0.36 -0.91 0.19 0.28 0.20
Time difference: Lockdown to baseline -1.33 -1.46 -1.21 0.06 1.86e-96
Highest education NVQ -3.74 -5.16 -2.31 0.73 3.03e-07
Highest education A-Levels -1.92 -2.80 -1.04 0.45 2.04e-05
Highest education University -1.38 -2.20 -0.57 0.42 8.90e-04
n R2 adjust. R2 F p value df
5455 0.06 0.05 53.30 3.86e-64 6

OCIR prepan

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 8.66 2.93 14.38 2.92 0.003
pcl.sum_score_prepan 0.61 0.51 0.70 0.05 3.45e-35
Depressive and anxiety disorder -4.64 -8.98 -0.29 2.22 0.04
Only depressive disorder -5.24 -9.97 -0.52 2.41 0.03
Only anxiety disorder -6.10 -10.81 -1.39 2.40 0.01
Eating disorders 0.54 -0.99 2.06 0.78 0.49
OCDs 7.14 5.82 8.46 0.67 1.55e-25
Psychotic and bipolar disorder 6.00 1.88 10.12 2.10 0.004
Only psychotic disorder 1.32 -1.74 4.39 1.56 0.40
Only bipolar disorder 1.87 -0.34 4.07 1.12 0.10
PTSD -0.22 -1.55 1.11 0.68 0.74
ASD 4.60 1.74 7.46 1.46 0.002
ADHD 0.32 -3.94 4.59 2.17 0.88
Personality disorder 1.55 -0.18 3.29 0.88 0.08
Female -0.12 -1.66 1.42 0.79 0.88
Non-binary/Self-defined 1.38 -2.26 5.02 1.86 0.46
age_category_collapsed_reordered16-18 1.13 -2.70 4.96 1.95 0.56
age_category_collapsed_reordered19-25 0.61 -1.16 2.38 0.90 0.50
age_category_collapsed_reordered36-45 -0.84 -2.43 0.76 0.81 0.30
age_category_collapsed_reordered46-55 0.32 -1.23 1.88 0.79 0.68
age_category_collapsed_reordered56-65 -1.33 -3.13 0.46 0.91 0.14
age_category_collapsed_reordered66-70 -0.32 -3.84 3.20 1.79 0.86
age_category_collapsed_reordered71-75 -2.00 -7.05 3.06 2.58 0.44
age_category_collapsed_reordered76+ 1.27 -9.51 12.04 5.49 0.82
Mixed or multiple ethnic origins 1.46 -1.85 4.78 1.69 0.39
Asian or Asian British 6.57 -1.05 14.19 3.89 0.09
African or African British 2.37 -8.32 13.05 5.45 0.66
Other ethnicity 3.28 -1.14 7.70 2.25 0.15
Key worker -0.75 -1.85 0.35 0.56 0.18
Time difference: Lockdown to baseline 0.28 -0.04 0.60 0.16 0.09
Highest education NVQ 0.78 -1.71 3.27 1.27 0.54
Highest education A-Levels -1.86 -3.83 0.10 1.00 0.06
Highest education University -2.67 -4.52 -0.83 0.94 0.004
n R2 adjust. R2 F p value df
1873 0.03 0.03 9.40 3.43e-10 6

PCL baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 10.62 10.29 10.96 0.17 0.00e+00
Depressive and anxiety disorder 5.16 5.01 5.30 0.07 0.00e+00
Only depressive disorder 2.64 2.46 2.83 0.09 1.39e-170
Only anxiety disorder 2.43 2.20 2.66 0.12 2.42e-92
Eating disorders 0.91 0.68 1.15 0.12 1.79e-14
OCDs 1.24 1.02 1.47 0.11 3.03e-27
Psychotic and bipolar disorder 1.31 0.67 1.94 0.32 5.21e-05
Only psychotic disorder 0.77 0.22 1.31 0.28 0.006
Only bipolar disorder 1.23 0.89 1.57 0.17 1.98e-12
PTSD 2.83 2.62 3.04 0.11 5.98e-154
ASD 1.08 0.68 1.49 0.21 2.00e-07
ADHD 0.55 0.01 1.09 0.28 0.05
Personality disorder 2.43 2.13 2.73 0.15 6.97e-57
Female 0.70 0.57 0.84 0.07 4.79e-24
Non-binary/Self-defined 1.24 0.70 1.78 0.27 6.53e-06
age_category_collapsed_reordered16-18 3.36 2.99 3.73 0.19 2.75e-70
age_category_collapsed_reordered19-25 1.70 1.46 1.95 0.13 1.26e-41
age_category_collapsed_reordered36-45 -0.63 -0.84 -0.43 0.11 2.00e-09
age_category_collapsed_reordered46-55 -0.98 -1.18 -0.79 0.10 3.03e-23
age_category_collapsed_reordered56-65 -1.77 -1.97 -1.58 0.10 1.39e-70
age_category_collapsed_reordered66-70 -2.49 -2.74 -2.24 0.13 2.42e-82
age_category_collapsed_reordered71-75 -2.65 -2.94 -2.36 0.15 1.64e-69
age_category_collapsed_reordered76+ -2.45 -2.90 -2.00 0.23 1.08e-26
Mixed or multiple ethnic origins 0.57 0.14 1.00 0.22 0.010
Asian or Asian British 0.69 0.17 1.20 0.26 0.009
African or African British 0.57 -0.37 1.51 0.48 0.24
Other ethnicity 0.80 0.03 1.56 0.39 0.04
Key worker -0.50 -0.62 -0.37 0.06 4.24e-15
Time difference: Lockdown to baseline -0.04 -0.06 -0.01 0.01 0.01
Highest education NVQ -0.16 -0.44 0.12 0.14 0.27
Highest education A-Levels -0.32 -0.53 -0.11 0.11 0.002
Highest education University -0.71 -0.90 -0.53 0.09 3.79e-14
n R2 adjust. R2 F p value df
32567 0.27 0.27 1987.28 0.00e+00 6

#PCL prepan ### Model 1b: Overlapping disorders, Adjusted Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 7.36 6.44 8.27 0.47 4.36e-55
pcl.sum_score_prepan 0.50 0.49 0.52 0.01 0.00e+00
Depressive and anxiety disorder 0.65 0.01 1.28 0.32 0.05
Only depressive disorder -0.18 -0.86 0.51 0.35 0.62
Only anxiety disorder -0.66 -1.37 0.06 0.36 0.07
Eating disorders 0.50 0.19 0.81 0.16 0.001
OCDs 0.49 0.20 0.77 0.15 9.24e-04
Psychotic and bipolar disorder -0.18 -1.01 0.66 0.43 0.68
Only psychotic disorder 0.00 -0.70 0.71 0.36 0.99
Only bipolar disorder 0.57 0.15 0.99 0.21 0.008
PTSD 0.81 0.54 1.09 0.14 8.79e-09
ASD 0.34 -0.22 0.91 0.29 0.23
ADHD 0.16 -0.61 0.93 0.39 0.68
Personality disorder 0.90 0.51 1.28 0.19 4.40e-06
Female 0.44 0.18 0.70 0.13 8.13e-04
Non-binary/Self-defined 0.45 -0.27 1.17 0.37 0.22
age_category_collapsed_reordered16-18 1.02 0.40 1.65 0.32 0.001
age_category_collapsed_reordered19-25 0.90 0.57 1.23 0.17 1.04e-07
age_category_collapsed_reordered36-45 -0.54 -0.83 -0.25 0.15 2.68e-04
age_category_collapsed_reordered46-55 -0.67 -0.95 -0.38 0.15 4.29e-06
age_category_collapsed_reordered56-65 -0.96 -1.28 -0.63 0.17 7.86e-09
age_category_collapsed_reordered66-70 -1.81 -2.39 -1.23 0.30 8.82e-10
age_category_collapsed_reordered71-75 -2.32 -3.10 -1.54 0.40 5.57e-09
age_category_collapsed_reordered76+ -2.10 -3.56 -0.64 0.75 0.005
Mixed or multiple ethnic origins 0.34 -0.31 0.99 0.33 0.31
Asian or Asian British 0.47 -0.62 1.56 0.56 0.40
African or African British -0.20 -1.95 1.54 0.89 0.82
Other ethnicity 0.28 -0.72 1.29 0.51 0.58
Key worker -0.53 -0.73 -0.33 0.10 1.40e-07
Time difference: Lockdown to baseline 0.09 0.03 0.15 0.03 0.003
Highest education NVQ -0.06 -0.54 0.41 0.24 0.80
Highest education A-Levels -0.64 -1.02 -0.26 0.19 0.001
Highest education University -0.79 -1.14 -0.44 0.18 1.21e-05
n R2 adjust. R2 F p value df
11940 0.01 0.01 30.02 6.05e-36 6

Sensitivity anlayses based on employment prior to covid

Function change to include employment prior to covid as predictors

GAD baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.43 5.14 5.72 0.15 2.91e-293
Depressive and anxiety disorder 4.39 4.25 4.54 0.07 0.00e+00
Only depressive disorder 1.75 1.57 1.93 0.09 2.07e-78
Only anxiety disorder 3.00 2.77 3.23 0.12 1.19e-141
Eating disorders 0.97 0.73 1.21 0.12 2.53e-15
OCDs 1.36 1.13 1.59 0.12 6.45e-31
Psychotic and bipolar disorder 0.98 0.31 1.65 0.34 0.004
Only psychotic disorder 0.22 -0.35 0.78 0.29 0.45
Only bipolar disorder 0.47 0.11 0.83 0.18 0.010
PTSD 1.44 1.22 1.66 0.11 6.78e-39
ASD 1.26 0.84 1.68 0.22 5.77e-09
ADHD 0.42 -0.14 0.97 0.28 0.14
Personality disorder 1.43 1.11 1.75 0.16 2.02e-18
Female 0.92 0.79 1.06 0.07 4.13e-41
Non-binary/Self-defined 0.70 0.15 1.25 0.28 0.01
age_category_collapsed_reordered16-18 3.09 2.71 3.47 0.19 6.20e-57
age_category_collapsed_reordered19-25 1.57 1.32 1.83 0.13 8.14e-34
age_category_collapsed_reordered36-45 -0.77 -0.99 -0.56 0.11 6.49e-13
age_category_collapsed_reordered46-55 -1.30 -1.50 -1.10 0.10 1.46e-38
age_category_collapsed_reordered56-65 -2.00 -2.20 -1.79 0.11 4.99e-80
age_category_collapsed_reordered66-70 -2.61 -2.90 -2.32 0.15 6.07e-70
age_category_collapsed_reordered71-75 -2.84 -3.16 -2.51 0.17 8.40e-66
age_category_collapsed_reordered76+ -2.70 -3.15 -2.25 0.23 5.08e-32
Mixed or multiple ethnic origins 0.15 -0.28 0.59 0.22 0.48
Asian or Asian British 0.05 -0.46 0.56 0.26 0.85
African or African British -0.41 -1.38 0.55 0.49 0.40
Other ethnicity 0.74 -0.02 1.51 0.39 0.06
Time difference: Lockdown to baseline -0.25 -0.28 -0.22 0.01 6.45e-67
Key worker 0.05 -0.09 0.20 0.07 0.47
Retired -0.19 -0.40 0.02 0.11 0.08
Student 0.60 0.27 0.92 0.16 2.77e-04
Unemployed 1.80 1.54 2.07 0.13 2.33e-41
n R2 adjust. R2 F p value df
32679 0.21 0.21 1485.53 0.00e+00 6

GAD retro

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.64 3.39 3.88 0.13 5.83e-177
gad.sum_score_retro 0.66 0.65 0.67 0.01 0.00e+00
Depressive and anxiety disorder 2.41 2.27 2.54 0.07 2.00e-262
Only depressive disorder 1.02 0.86 1.18 0.08 1.50e-36
Only anxiety disorder 1.76 1.56 1.97 0.10 4.85e-66
Eating disorders 0.55 0.34 0.76 0.11 2.52e-07
OCDs 0.47 0.27 0.68 0.10 4.01e-06
Psychotic and bipolar disorder 0.72 0.14 1.30 0.30 0.02
Only psychotic disorder 0.00 -0.50 0.50 0.25 1.00
Only bipolar disorder 0.32 0.00 0.64 0.16 0.05
PTSD 0.77 0.58 0.96 0.10 1.49e-15
ASD 0.65 0.28 1.02 0.19 5.64e-04
ADHD 0.10 -0.39 0.58 0.25 0.70
Personality disorder 0.44 0.17 0.72 0.14 0.002
Female 0.78 0.66 0.89 0.06 3.12e-39
Non-binary/Self-defined 0.13 -0.34 0.60 0.24 0.59
age_category_collapsed_reordered16-18 0.89 0.56 1.21 0.17 9.99e-08
age_category_collapsed_reordered19-25 0.89 0.67 1.11 0.11 1.03e-15
age_category_collapsed_reordered36-45 -0.57 -0.75 -0.39 0.09 9.59e-10
age_category_collapsed_reordered46-55 -0.87 -1.04 -0.70 0.09 1.10e-23
age_category_collapsed_reordered56-65 -1.19 -1.37 -1.01 0.09 3.65e-39
age_category_collapsed_reordered66-70 -1.58 -1.83 -1.33 0.13 2.29e-35
age_category_collapsed_reordered71-75 -1.78 -2.06 -1.50 0.14 9.33e-36
age_category_collapsed_reordered76+ -1.82 -2.20 -1.43 0.20 2.57e-20
Mixed or multiple ethnic origins -0.19 -0.56 0.18 0.19 0.31
Asian or Asian British -0.19 -0.62 0.25 0.22 0.40
African or African British -0.65 -1.48 0.18 0.42 0.12
Other ethnicity 0.40 -0.27 1.07 0.34 0.24
Time difference: Lockdown to baseline -0.22 -0.24 -0.19 0.01 2.91e-67
Key worker 0.19 0.06 0.31 0.06 0.003
Retired -0.12 -0.30 0.06 0.09 0.20
Student 0.34 0.07 0.61 0.14 0.02
Unemployed 0.42 0.19 0.64 0.12 3.38e-04
n R2 adjust. R2 F p value df
30973 0.25 0.25 1678.24 0.00e+00 6

GAD prepan

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.00 2.20 3.80 0.41 1.91e-13
gad.sum_score_prepan 0.48 0.46 0.49 0.01 0.00e+00
Depressive and anxiety disorder 0.85 0.25 1.45 0.31 0.006
Only depressive disorder -0.03 -0.68 0.62 0.33 0.93
Only anxiety disorder 0.08 -0.60 0.76 0.35 0.81
Eating disorders 0.70 0.40 1.00 0.15 5.34e-06
OCDs 0.53 0.25 0.81 0.14 2.40e-04
Psychotic and bipolar disorder -0.17 -1.02 0.68 0.43 0.70
Only psychotic disorder 0.21 -0.48 0.90 0.35 0.55
Only bipolar disorder 0.24 -0.17 0.66 0.21 0.25
PTSD 0.78 0.51 1.04 0.14 1.73e-08
ASD 0.74 0.18 1.30 0.29 0.009
ADHD -0.24 -1.01 0.52 0.39 0.53
Personality disorder 0.58 0.19 0.97 0.20 0.003
Female 0.40 0.15 0.64 0.13 0.002
Non-binary/Self-defined 0.44 -0.27 1.14 0.36 0.23
age_category_collapsed_reordered16-18 1.08 0.49 1.67 0.30 3.64e-04
age_category_collapsed_reordered19-25 0.79 0.46 1.11 0.17 1.91e-06
age_category_collapsed_reordered36-45 -0.21 -0.49 0.07 0.14 0.15
age_category_collapsed_reordered46-55 -0.56 -0.84 -0.28 0.14 7.33e-05
age_category_collapsed_reordered56-65 -0.90 -1.25 -0.56 0.18 2.58e-07
age_category_collapsed_reordered66-70 -1.67 -2.28 -1.05 0.31 1.11e-07
age_category_collapsed_reordered71-75 -1.89 -2.67 -1.12 0.40 1.76e-06
age_category_collapsed_reordered76+ -1.35 -2.73 0.02 0.70 0.05
Mixed or multiple ethnic origins 0.22 -0.42 0.85 0.32 0.51
Asian or Asian British -0.12 -1.14 0.90 0.52 0.82
African or African British -0.66 -2.35 1.03 0.86 0.45
Other ethnicity 0.39 -0.57 1.35 0.49 0.42
Time difference: Lockdown to baseline 0.00 -0.06 0.05 0.03 0.92
Key worker 0.15 -0.08 0.37 0.11 0.19
Retired 0.07 -0.35 0.49 0.21 0.75
Student 0.31 -0.14 0.76 0.23 0.17
Unemployed 0.98 0.63 1.34 0.18 4.59e-08
n R2 adjust. R2 F p value df
12028 0.00 0.00 8.99 7.92e-10 6

PHQ baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.03 5.71 6.36 0.16 3.80e-286
Depressive and anxiety disorder 5.25 5.09 5.41 0.08 0.00e+00
Only depressive disorder 3.26 3.06 3.47 0.10 1.82e-209
Only anxiety disorder 1.97 1.71 2.23 0.13 1.12e-49
Eating disorders 1.55 1.28 1.82 0.14 1.81e-29
OCDs 1.29 1.03 1.55 0.13 2.57e-22
Psychotic and bipolar disorder 0.47 -0.28 1.23 0.38 0.22
Only psychotic disorder 0.48 -0.16 1.11 0.32 0.14
Only bipolar disorder 1.19 0.79 1.59 0.21 7.85e-09
PTSD 1.80 1.56 2.04 0.12 1.65e-47
ASD 1.25 0.77 1.72 0.24 3.09e-07
ADHD 1.20 0.57 1.82 0.32 1.73e-04
Personality disorder 2.42 2.06 2.78 0.18 2.21e-39
Female 0.86 0.71 1.01 0.08 1.39e-28
Non-binary/Self-defined 1.36 0.74 1.98 0.31 1.63e-05
age_category_collapsed_reordered16-18 5.52 5.09 5.95 0.22 1.45e-139
age_category_collapsed_reordered19-25 2.06 1.77 2.34 0.15 3.50e-45
age_category_collapsed_reordered36-45 -0.78 -1.01 -0.54 0.12 1.41e-10
age_category_collapsed_reordered46-55 -1.10 -1.32 -0.88 0.11 1.57e-22
age_category_collapsed_reordered56-65 -1.94 -2.17 -1.71 0.12 2.52e-60
age_category_collapsed_reordered66-70 -2.76 -3.08 -2.43 0.17 8.55e-62
age_category_collapsed_reordered71-75 -2.93 -3.29 -2.57 0.19 9.47e-56
age_category_collapsed_reordered76+ -2.78 -3.29 -2.28 0.26 3.86e-27
Mixed or multiple ethnic origins 0.43 -0.06 0.91 0.25 0.08
Asian or Asian British 0.24 -0.34 0.81 0.29 0.42
African or African British -0.43 -1.51 0.66 0.55 0.44
Other ethnicity 1.02 0.16 1.88 0.44 0.02
Time difference: Lockdown to baseline -0.23 -0.26 -0.20 0.02 5.19e-44
Key worker 0.03 -0.13 0.19 0.08 0.71
Retired -0.04 -0.28 0.19 0.12 0.72
Student 1.07 0.71 1.43 0.18 6.60e-09
Unemployed 3.27 2.97 3.56 0.15 7.25e-104
n R2 adjust. R2 F p value df
32662 0.25 0.25 1854.75 0.00e+00 6

PHQ retro

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.10 3.84 4.37 0.14 4.96e-193
phq.sum_score_retro 0.68 0.66 0.69 0.01 0.00e+00
Depressive and anxiety disorder 2.68 2.53 2.83 0.07 3.84e-277
Only depressive disorder 1.69 1.52 1.86 0.09 2.24e-81
Only anxiety disorder 1.18 0.96 1.40 0.11 9.64e-27
Eating disorders 0.79 0.56 1.01 0.12 7.75e-12
OCDs 0.46 0.24 0.67 0.11 3.82e-05
Psychotic and bipolar disorder 0.02 -0.61 0.65 0.32 0.95
Only psychotic disorder -0.05 -0.59 0.49 0.28 0.85
Only bipolar disorder 0.64 0.30 0.99 0.18 2.59e-04
PTSD 0.93 0.73 1.13 0.10 3.86e-19
ASD 0.55 0.15 0.95 0.20 0.007
ADHD 0.34 -0.19 0.86 0.27 0.21
Personality disorder 0.80 0.50 1.10 0.15 1.97e-07
Female 0.74 0.61 0.86 0.06 1.20e-30
Non-binary/Self-defined 0.54 0.03 1.05 0.26 0.04
age_category_collapsed_reordered16-18 2.82 2.46 3.17 0.18 5.88e-55
age_category_collapsed_reordered19-25 1.20 0.96 1.43 0.12 1.97e-23
age_category_collapsed_reordered36-45 -0.59 -0.79 -0.40 0.10 3.85e-09
age_category_collapsed_reordered46-55 -0.77 -0.95 -0.59 0.09 1.94e-16
age_category_collapsed_reordered56-65 -1.16 -1.35 -0.97 0.10 3.13e-32
age_category_collapsed_reordered66-70 -1.59 -1.86 -1.32 0.14 6.05e-31
age_category_collapsed_reordered71-75 -1.75 -2.05 -1.45 0.15 7.25e-30
age_category_collapsed_reordered76+ -1.77 -2.19 -1.35 0.21 1.04e-16
Mixed or multiple ethnic origins 0.12 -0.28 0.52 0.20 0.55
Asian or Asian British 0.00 -0.47 0.47 0.24 1.00
African or African British -0.43 -1.32 0.46 0.46 0.34
Other ethnicity 0.48 -0.24 1.20 0.37 0.19
Time difference: Lockdown to baseline -0.22 -0.25 -0.19 0.01 4.59e-58
Key worker 0.11 -0.02 0.24 0.07 0.10
Retired -0.19 -0.39 0.00 0.10 0.06
Student 0.44 0.15 0.74 0.15 0.003
Unemployed 0.65 0.40 0.90 0.13 2.92e-07
n R2 adjust. R2 F p value df
30959 0.28 0.28 2029.98 0.00e+00 6

PHQ prepan

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.51 1.66 3.37 0.44 7.90e-09
phq.sum_score_prepan 0.54 0.53 0.56 0.01 0.00e+00
Depressive and anxiety disorder 1.25 0.61 1.90 0.33 1.29e-04
Only depressive disorder 0.80 0.11 1.49 0.35 0.02
Only anxiety disorder 0.20 -0.53 0.92 0.37 0.59
Eating disorders 0.95 0.63 1.27 0.16 8.00e-09
OCDs 0.51 0.21 0.82 0.15 7.98e-04
Psychotic and bipolar disorder -0.82 -1.73 0.09 0.46 0.08
Only psychotic disorder 0.14 -0.59 0.88 0.38 0.70
Only bipolar disorder 0.27 -0.17 0.72 0.23 0.23
PTSD 0.57 0.28 0.86 0.15 9.92e-05
ASD 0.66 0.06 1.25 0.30 0.03
ADHD 0.35 -0.47 1.16 0.42 0.41
Personality disorder 0.90 0.49 1.31 0.21 1.73e-05
Female 0.15 -0.12 0.41 0.13 0.28
Non-binary/Self-defined 0.28 -0.48 1.03 0.38 0.47
age_category_collapsed_reordered16-18 1.92 1.28 2.55 0.32 3.07e-09
age_category_collapsed_reordered19-25 0.88 0.54 1.23 0.18 5.57e-07
age_category_collapsed_reordered36-45 -0.26 -0.56 0.05 0.15 0.10
age_category_collapsed_reordered46-55 -0.54 -0.83 -0.24 0.15 3.83e-04
age_category_collapsed_reordered56-65 -1.03 -1.39 -0.66 0.19 3.50e-08
age_category_collapsed_reordered66-70 -1.82 -2.47 -1.17 0.33 4.80e-08
age_category_collapsed_reordered71-75 -2.31 -3.14 -1.48 0.42 4.64e-08
age_category_collapsed_reordered76+ -1.71 -3.18 -0.23 0.75 0.02
Mixed or multiple ethnic origins 0.25 -0.43 0.92 0.34 0.48
Asian or Asian British -0.70 -1.78 0.38 0.55 0.20
African or African British -0.20 -1.99 1.60 0.92 0.83
Other ethnicity 0.16 -0.87 1.19 0.53 0.76
Time difference: Lockdown to baseline 0.08 0.01 0.14 0.03 0.01
Key worker 0.06 -0.18 0.29 0.12 0.64
Retired 0.40 -0.05 0.84 0.23 0.08
Student 0.55 0.07 1.02 0.24 0.02
Unemployed 1.42 1.05 1.80 0.19 1.81e-13
n R2 adjust. R2 F p value df
12024 0.02 0.02 41.62 1.65e-50 6

OCIR baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.55 13.93 17.18 0.83 1.41e-75
Depressive and anxiety disorder 3.06 2.16 3.96 0.46 2.95e-11
Only depressive disorder 0.39 -0.81 1.60 0.62 0.52
Only anxiety disorder 1.00 -0.23 2.22 0.62 0.11
Eating disorders 0.59 -0.52 1.69 0.56 0.30
OCDs 6.39 5.42 7.36 0.49 1.78e-37
Psychotic and bipolar disorder 6.53 3.92 9.14 1.33 9.80e-07
Only psychotic disorder 3.52 1.06 5.98 1.26 0.005
Only bipolar disorder 2.98 1.24 4.73 0.89 7.81e-04
PTSD 1.99 1.01 2.97 0.50 6.59e-05
ASD 7.23 5.45 9.00 0.91 2.01e-15
ADHD 2.14 -0.25 4.53 1.22 0.08
Personality disorder 2.70 1.30 4.11 0.72 1.65e-04
Female -1.11 -2.03 -0.19 0.47 0.02
Non-binary/Self-defined -0.89 -3.43 1.65 1.30 0.49
age_category_collapsed_reordered16-18 8.54 6.87 10.21 0.85 2.00e-23
age_category_collapsed_reordered19-25 1.93 0.67 3.18 0.64 0.003
age_category_collapsed_reordered36-45 -0.42 -1.61 0.77 0.61 0.49
age_category_collapsed_reordered46-55 -0.25 -1.35 0.86 0.56 0.66
age_category_collapsed_reordered56-65 -0.62 -1.79 0.55 0.60 0.30
age_category_collapsed_reordered66-70 0.28 -1.56 2.12 0.94 0.77
age_category_collapsed_reordered71-75 -0.79 -2.93 1.35 1.09 0.47
age_category_collapsed_reordered76+ -2.52 -6.10 1.06 1.83 0.17
Mixed or multiple ethnic origins 0.88 -1.33 3.09 1.13 0.43
Asian or Asian British 5.32 2.47 8.17 1.45 2.50e-04
African or African British -0.45 -7.25 6.36 3.47 0.90
Other ethnicity 3.05 -0.25 6.34 1.68 0.07
Time difference: Lockdown to baseline -0.44 -0.60 -0.29 0.08 2.72e-08
Key worker 0.02 -0.81 0.85 0.42 0.96
Retired -0.45 -1.76 0.86 0.67 0.50
Student -0.09 -1.60 1.42 0.77 0.90
Unemployed 3.73 2.46 5.00 0.65 8.65e-09
n R2 adjust. R2 F p value df
5506 0.05 0.05 52.82 1.41e-63 6

OCIR retro

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.95 11.63 14.27 0.67 3.15e-79
ocir.sum_score_retro 0.74 0.71 0.76 0.01 0.00e+00
Depressive and anxiety disorder -1.13 -1.87 -0.39 0.38 0.003
Only depressive disorder -0.96 -1.95 0.03 0.51 0.06
Only anxiety disorder -0.18 -1.18 0.83 0.51 0.73
Eating disorders 0.05 -0.83 0.92 0.45 0.92
OCDs 1.93 1.16 2.70 0.39 9.08e-07
Psychotic and bipolar disorder 3.06 1.04 5.09 1.03 0.003
Only psychotic disorder 0.73 -1.17 2.63 0.97 0.45
Only bipolar disorder 0.41 -0.89 1.72 0.67 0.54
PTSD 0.49 -0.27 1.25 0.39 0.21
ASD 2.41 0.99 3.83 0.72 8.79e-04
ADHD 1.92 -0.04 3.88 1.00 0.05
Personality disorder 0.60 -0.48 1.68 0.55 0.28
Female -0.02 -0.75 0.71 0.37 0.96
Non-binary/Self-defined -0.31 -2.32 1.71 1.03 0.77
age_category_collapsed_reordered16-18 5.16 3.75 6.58 0.72 1.09e-12
age_category_collapsed_reordered19-25 0.15 -0.84 1.14 0.50 0.77
age_category_collapsed_reordered36-45 -0.26 -1.17 0.66 0.47 0.58
age_category_collapsed_reordered46-55 -0.01 -0.86 0.85 0.44 0.99
age_category_collapsed_reordered56-65 1.20 0.28 2.12 0.47 0.01
age_category_collapsed_reordered66-70 1.91 0.45 3.38 0.75 0.01
age_category_collapsed_reordered71-75 1.57 -0.16 3.30 0.88 0.08
age_category_collapsed_reordered76+ -0.49 -3.72 2.74 1.65 0.76
Mixed or multiple ethnic origins 1.09 -0.64 2.81 0.88 0.22
Asian or Asian British 3.72 1.25 6.19 1.26 0.003
African or African British -0.78 -6.52 4.95 2.93 0.79
Other ethnicity 1.56 -0.95 4.07 1.28 0.22
Time difference: Lockdown to baseline -1.36 -1.48 -1.23 0.06 1.07e-95
Key worker -0.09 -0.74 0.56 0.33 0.78
Retired -0.33 -1.37 0.71 0.53 0.54
Student -0.26 -1.50 0.99 0.63 0.69
Unemployed 1.38 0.38 2.38 0.51 0.007
n R2 adjust. R2 F p value df
5455 0.06 0.05 53.30 3.86e-64 6

OCIR prepan

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.39 -6.55 13.33 5.05 0.50
ocir.sum_score_prepan 0.65 0.57 0.73 0.04 2.08e-45
Depressive and anxiety disorder -4.41 -12.18 3.36 3.95 0.27
Only depressive disorder -5.27 -13.66 3.12 4.27 0.22
Only anxiety disorder -7.72 -16.17 0.72 4.29 0.07
Eating disorders 0.96 -1.62 3.54 1.31 0.47
OCDs 1.44 -0.82 3.70 1.15 0.21
Psychotic and bipolar disorder 10.01 2.01 18.01 4.07 0.01
Only psychotic disorder -0.38 -6.01 5.24 2.86 0.89
Only bipolar disorder -0.93 -4.56 2.70 1.85 0.61
PTSD -2.55 -5.07 -0.03 1.28 0.05
ASD 1.02 -3.21 5.24 2.15 0.64
ADHD 0.68 -6.22 7.58 3.51 0.85
Personality disorder 0.61 -2.59 3.81 1.63 0.71
Female -1.97 -4.98 1.05 1.53 0.20
Non-binary/Self-defined -1.14 -7.03 4.75 3.00 0.70
age_category_collapsed_reordered16-18 -4.50 -10.66 1.66 3.13 0.15
age_category_collapsed_reordered19-25 -0.92 -3.76 1.93 1.45 0.53
age_category_collapsed_reordered36-45 -0.64 -3.51 2.24 1.46 0.66
age_category_collapsed_reordered46-55 2.11 -0.86 5.08 1.51 0.16
age_category_collapsed_reordered56-65 -4.28 -8.53 -0.03 2.16 0.05
age_category_collapsed_reordered66-70 -3.86 -10.56 2.85 3.41 0.26
age_category_collapsed_reordered71-75 -2.79 -12.84 7.25 5.11 0.58
Mixed or multiple ethnic origins -0.24 -6.52 6.04 3.19 0.94
Asian or Asian British -13.18 -26.48 0.12 6.76 0.05
Other ethnicity 2.26 -5.39 9.92 3.89 0.56
Time difference: Lockdown to baseline 0.62 -0.10 1.33 0.36 0.09
Key worker 0.22 -2.12 2.55 1.19 0.85
Retired 3.55 -1.14 8.24 2.39 0.14
Student -1.57 -5.36 2.23 1.93 0.42
Unemployed 0.70 -2.46 3.86 1.61 0.66
n R2 adjust. R2 F p value df
1873 0.03 0.03 9.40 3.43e-10 6

PCL baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.77 9.49 10.05 0.14 0.00e+00
Depressive and anxiety disorder 5.00 4.86 5.15 0.07 0.00e+00
Only depressive disorder 2.58 2.40 2.76 0.09 4.64e-171
Only anxiety disorder 2.40 2.17 2.62 0.12 9.15e-94
Eating disorders 0.82 0.58 1.06 0.12 9.75e-12
OCDs 1.19 0.97 1.42 0.12 9.47e-25
Psychotic and bipolar disorder 1.50 0.84 2.15 0.34 8.22e-06
Only psychotic disorder 0.43 -0.13 0.98 0.28 0.13
Only bipolar disorder 0.98 0.62 1.33 0.18 6.63e-08
PTSD 2.69 2.48 2.91 0.11 4.58e-134
ASD 1.05 0.63 1.47 0.21 8.16e-07
ADHD 0.68 0.13 1.24 0.28 0.02
Personality disorder 2.14 1.82 2.45 0.16 4.91e-40
Female 0.71 0.58 0.84 0.07 1.25e-25
Non-binary/Self-defined 1.22 0.68 1.76 0.28 9.71e-06
age_category_collapsed_reordered16-18 3.44 3.07 3.82 0.19 4.21e-72
age_category_collapsed_reordered19-25 1.65 1.40 1.90 0.13 6.06e-38
age_category_collapsed_reordered36-45 -0.70 -0.91 -0.50 0.11 3.53e-11
age_category_collapsed_reordered46-55 -1.04 -1.23 -0.85 0.10 4.69e-26
age_category_collapsed_reordered56-65 -1.63 -1.83 -1.42 0.10 3.02e-55
age_category_collapsed_reordered66-70 -2.03 -2.31 -1.74 0.15 3.74e-44
age_category_collapsed_reordered71-75 -2.20 -2.52 -1.88 0.16 1.50e-41
age_category_collapsed_reordered76+ -2.02 -2.46 -1.57 0.23 4.54e-19
Mixed or multiple ethnic origins 0.53 0.10 0.95 0.22 0.02
Asian or Asian British 0.69 0.18 1.19 0.26 0.007
African or African British 0.56 -0.39 1.51 0.48 0.25
Other ethnicity 0.79 0.04 1.54 0.38 0.04
Time difference: Lockdown to baseline -0.03 -0.06 -0.01 0.01 0.02
Key worker -0.08 -0.22 0.06 0.07 0.26
Retired -0.13 -0.34 0.08 0.11 0.22
Student 0.72 0.40 1.03 0.16 9.01e-06
Unemployed 2.37 2.11 2.63 0.13 5.98e-72
n R2 adjust. R2 F p value df
32567 0.27 0.27 1987.28 0.00e+00 6

#PCL prepan ### Model 1b: Overlapping disorders, Adjusted Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.29 5.43 7.15 0.44 3.13e-46
pcl.sum_score_prepan 0.50 0.48 0.52 0.01 0.00e+00
Depressive and anxiety disorder 0.64 0.01 1.27 0.32 0.05
Only depressive disorder -0.13 -0.82 0.55 0.35 0.70
Only anxiety disorder -0.65 -1.36 0.07 0.36 0.08
Eating disorders 0.43 0.11 0.75 0.16 0.008
OCDs 0.46 0.16 0.76 0.15 0.002
Psychotic and bipolar disorder -0.23 -1.12 0.65 0.45 0.61
Only psychotic disorder -0.13 -0.86 0.60 0.37 0.73
Only bipolar disorder 0.44 0.00 0.88 0.23 0.05
PTSD 0.80 0.51 1.09 0.15 5.26e-08
ASD 0.45 -0.14 1.04 0.30 0.14
ADHD 0.34 -0.48 1.16 0.42 0.41
Personality disorder 0.65 0.25 1.06 0.21 0.002
Female 0.52 0.25 0.78 0.13 1.05e-04
Non-binary/Self-defined 0.52 -0.22 1.27 0.38 0.17
age_category_collapsed_reordered16-18 1.15 0.52 1.77 0.32 3.18e-04
age_category_collapsed_reordered19-25 0.87 0.53 1.21 0.17 6.28e-07
age_category_collapsed_reordered36-45 -0.59 -0.89 -0.29 0.15 1.07e-04
age_category_collapsed_reordered46-55 -0.71 -1.00 -0.41 0.15 2.25e-06
age_category_collapsed_reordered56-65 -0.83 -1.19 -0.47 0.18 6.52e-06
age_category_collapsed_reordered66-70 -1.59 -2.24 -0.95 0.33 1.33e-06
age_category_collapsed_reordered71-75 -1.94 -2.76 -1.12 0.42 3.66e-06
age_category_collapsed_reordered76+ -1.53 -2.98 -0.07 0.74 0.04
Mixed or multiple ethnic origins 0.35 -0.31 1.02 0.34 0.30
Asian or Asian British 0.53 -0.55 1.62 0.55 0.33
African or African British 0.37 -1.39 2.14 0.90 0.68
Other ethnicity 0.19 -0.82 1.21 0.52 0.71
Time difference: Lockdown to baseline 0.10 0.04 0.16 0.03 7.03e-04
Key worker -0.25 -0.48 -0.01 0.12 0.04
Retired -0.03 -0.47 0.41 0.22 0.88
Student 0.27 -0.20 0.74 0.24 0.26
Unemployed 1.21 0.83 1.58 0.19 2.20e-10
n R2 adjust. R2 F p value df
11940 0.01 0.01 30.02 6.05e-36 6

Sensitivity anlayses based on employment change

Function change to include employment change as predictors

GAD baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 9.24 8.63 9.85 0.31 1.13e-188
Depressive and anxiety disorder 4.77 4.59 4.96 0.09 0.00e+00
Only depressive disorder 1.98 1.74 2.22 0.12 3.94e-57
Only anxiety disorder 3.28 2.98 3.58 0.15 1.87e-100
Eating disorders 0.69 0.40 0.97 0.14 1.94e-06
OCDs 1.36 1.09 1.62 0.14 3.65e-23
Psychotic and bipolar disorder 0.59 -0.17 1.35 0.39 0.13
Only psychotic disorder 0.24 -0.42 0.91 0.34 0.47
Only bipolar disorder 0.71 0.30 1.12 0.21 6.25e-04
PTSD 1.47 1.22 1.72 0.13 1.10e-30
ASD 1.05 0.55 1.55 0.25 3.70e-05
ADHD 0.41 -0.23 1.05 0.33 0.21
Personality disorder 1.96 1.61 2.31 0.18 3.92e-28
Female 0.98 0.80 1.15 0.09 6.41e-27
Non-binary/Self-defined 0.78 0.10 1.46 0.35 0.02
19-25 years -2.04 -2.61 -1.47 0.29 2.25e-12
26-35 years -3.53 -4.07 -2.99 0.27 8.94e-38
36-45 years -4.19 -4.73 -3.65 0.28 8.73e-52
46-55 years -4.65 -5.19 -4.12 0.27 9.12e-65
56-65 years -5.22 -5.77 -4.68 0.28 2.70e-79
66-70 years -6.53 -7.22 -5.84 0.35 8.47e-76
71-75 years -6.03 -6.88 -5.18 0.43 9.89e-44
76+ years -5.29 -6.68 -3.90 0.71 8.82e-14
Mixed or multiple ethnic origins 0.00 -0.52 0.52 0.26 0.99
Asian or Asian British 0.24 -0.42 0.89 0.34 0.48
African or African British -0.34 -1.45 0.77 0.57 0.54
Other ethnicity 0.53 -0.41 1.48 0.48 0.27
Key worker -0.50 -0.64 -0.35 0.08 3.95e-11
Time difference: Lockdown to baseline -0.24 -0.28 -0.21 0.02 1.10e-41
Increased employment 0.31 -0.06 0.68 0.19 0.10
Furloughed -0.32 -0.59 -0.05 0.14 0.02
employment_changeEmployment not changed -0.33 -0.53 -0.12 0.11 0.002

GAD retro

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.64 3.39 3.88 0.13 5.83e-177
gad.sum_score_retro 0.66 0.65 0.67 0.01 0.00e+00
Depressive and anxiety disorder 2.41 2.27 2.54 0.07 2.00e-262
Only depressive disorder 1.02 0.86 1.18 0.08 1.50e-36
Only anxiety disorder 1.76 1.56 1.97 0.10 4.85e-66
Eating disorders 0.55 0.34 0.76 0.11 2.52e-07
OCDs 0.47 0.27 0.68 0.10 4.01e-06
Psychotic and bipolar disorder 0.72 0.14 1.30 0.30 0.02
Only psychotic disorder 0.00 -0.50 0.50 0.25 1.00
Only bipolar disorder 0.32 0.00 0.64 0.16 0.05
PTSD 0.77 0.58 0.96 0.10 1.49e-15
ASD 0.65 0.28 1.02 0.19 5.64e-04
ADHD 0.10 -0.39 0.58 0.25 0.70
Personality disorder 0.44 0.17 0.72 0.14 0.002
Female 0.78 0.66 0.89 0.06 3.12e-39
Non-binary/Self-defined 0.13 -0.34 0.60 0.24 0.59
age_category_collapsed_reordered16-18 0.89 0.56 1.21 0.17 9.99e-08
age_category_collapsed_reordered19-25 0.89 0.67 1.11 0.11 1.03e-15
age_category_collapsed_reordered36-45 -0.57 -0.75 -0.39 0.09 9.59e-10
age_category_collapsed_reordered46-55 -0.87 -1.04 -0.70 0.09 1.10e-23
age_category_collapsed_reordered56-65 -1.19 -1.37 -1.01 0.09 3.65e-39
age_category_collapsed_reordered66-70 -1.58 -1.83 -1.33 0.13 2.29e-35
age_category_collapsed_reordered71-75 -1.78 -2.06 -1.50 0.14 9.33e-36
age_category_collapsed_reordered76+ -1.82 -2.20 -1.43 0.20 2.57e-20
Mixed or multiple ethnic origins -0.19 -0.56 0.18 0.19 0.31
Asian or Asian British -0.19 -0.62 0.25 0.22 0.40
African or African British -0.65 -1.48 0.18 0.42 0.12
Other ethnicity 0.40 -0.27 1.07 0.34 0.24
Key worker 0.19 0.06 0.31 0.06 0.003
Retired -0.12 -0.30 0.06 0.09 0.20
Student 0.34 0.07 0.61 0.14 0.02
Unemployed 0.42 0.19 0.64 0.12 3.38e-04
Time difference: Lockdown to baseline -0.22 -0.24 -0.19 0.01 2.91e-67

GAD prepan

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.00 2.20 3.80 0.41 1.91e-13
gad.sum_score_prepan 0.48 0.46 0.49 0.01 0.00e+00
Depressive and anxiety disorder 0.85 0.25 1.45 0.31 0.006
Only depressive disorder -0.03 -0.68 0.62 0.33 0.93
Only anxiety disorder 0.08 -0.60 0.76 0.35 0.81
Eating disorders 0.70 0.40 1.00 0.15 5.34e-06
OCDs 0.53 0.25 0.81 0.14 2.40e-04
Psychotic and bipolar disorder -0.17 -1.02 0.68 0.43 0.70
Only psychotic disorder 0.21 -0.48 0.90 0.35 0.55
Only bipolar disorder 0.24 -0.17 0.66 0.21 0.25
PTSD 0.78 0.51 1.04 0.14 1.73e-08
ASD 0.74 0.18 1.30 0.29 0.009
ADHD -0.24 -1.01 0.52 0.39 0.53
Personality disorder 0.58 0.19 0.97 0.20 0.003
Female 0.40 0.15 0.64 0.13 0.002
Non-binary/Self-defined 0.44 -0.27 1.14 0.36 0.23
age_category_collapsed_reordered16-18 1.08 0.49 1.67 0.30 3.64e-04
age_category_collapsed_reordered19-25 0.79 0.46 1.11 0.17 1.91e-06
age_category_collapsed_reordered36-45 -0.21 -0.49 0.07 0.14 0.15
age_category_collapsed_reordered46-55 -0.56 -0.84 -0.28 0.14 7.33e-05
age_category_collapsed_reordered56-65 -0.90 -1.25 -0.56 0.18 2.58e-07
age_category_collapsed_reordered66-70 -1.67 -2.28 -1.05 0.31 1.11e-07
age_category_collapsed_reordered71-75 -1.89 -2.67 -1.12 0.40 1.76e-06
age_category_collapsed_reordered76+ -1.35 -2.73 0.02 0.70 0.05
Mixed or multiple ethnic origins 0.22 -0.42 0.85 0.32 0.51
Asian or Asian British -0.12 -1.14 0.90 0.52 0.82
African or African British -0.66 -2.35 1.03 0.86 0.45
Other ethnicity 0.39 -0.57 1.35 0.49 0.42
Key worker 0.15 -0.08 0.37 0.11 0.19
Retired 0.07 -0.35 0.49 0.21 0.75
Student 0.31 -0.14 0.76 0.23 0.17
Unemployed 0.98 0.63 1.34 0.18 4.59e-08
Time difference: Lockdown to baseline 0.00 -0.06 0.05 0.03 0.92

GAD retro GLAD and EDGI sensitivity

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 3.72 2.96 4.48 0.39 1.26e-21
gad.sum_score_retro 0.63 0.61 0.65 0.01 0.00e+00
Depressive and anxiety disorder 0.88 0.30 1.46 0.29 0.003
Only depressive disorder -0.14 -0.76 0.48 0.32 0.66
Only anxiety disorder 0.58 -0.07 1.23 0.33 0.08
Eating disorders 0.66 0.37 0.95 0.15 8.31e-06
OCDs 0.41 0.14 0.69 0.14 0.003
Psychotic and bipolar disorder 0.31 -0.50 1.13 0.42 0.45
Only psychotic disorder -0.17 -0.84 0.50 0.34 0.62
Only bipolar disorder 0.08 -0.32 0.49 0.21 0.69
PTSD 0.81 0.55 1.07 0.13 9.02e-10
ASD 0.59 0.06 1.13 0.28 0.03
ADHD 0.12 -0.62 0.86 0.38 0.74
Personality disorder 0.52 0.15 0.89 0.19 0.006
Female 0.50 0.26 0.73 0.12 4.23e-05
Non-binary/Self-defined -0.13 -0.81 0.56 0.35 0.71
age_category_collapsed_reordered16-18 0.71 0.14 1.28 0.29 0.02
age_category_collapsed_reordered19-25 0.91 0.59 1.22 0.16 1.34e-08
age_category_collapsed_reordered36-45 -0.48 -0.75 -0.21 0.14 5.18e-04
age_category_collapsed_reordered46-55 -0.80 -1.07 -0.54 0.14 4.04e-09
age_category_collapsed_reordered56-65 -1.28 -1.61 -0.95 0.17 3.18e-14
age_category_collapsed_reordered66-70 -1.80 -2.39 -1.21 0.30 2.39e-09
age_category_collapsed_reordered71-75 -2.11 -2.86 -1.37 0.38 2.91e-08
age_category_collapsed_reordered76+ -2.36 -3.69 -1.02 0.68 5.40e-04
Mixed or multiple ethnic origins -0.28 -0.88 0.33 0.31 0.37
Asian or Asian British 0.10 -0.88 1.08 0.50 0.84
African or African British -0.61 -2.24 1.02 0.83 0.46
Other ethnicity 0.25 -0.68 1.18 0.48 0.60
Key worker 0.25 0.03 0.46 0.11 0.02
Retired -0.03 -0.43 0.37 0.21 0.89
Student 0.52 0.09 0.95 0.22 0.02
Unemployed 0.67 0.33 1.01 0.17 1.18e-04
Time difference: Lockdown to baseline -0.04 -0.09 0.02 0.03 0.17

PHQ baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.44 11.76 13.13 0.35 6.35e-269
Depressive and anxiety disorder 5.67 5.46 5.88 0.11 0.00e+00
Only depressive disorder 3.56 3.29 3.84 0.14 5.09e-143
Only anxiety disorder 2.13 1.79 2.46 0.17 3.98e-35
Eating disorders 1.37 1.06 1.69 0.16 1.65e-17
OCDs 1.35 1.05 1.65 0.15 1.57e-18
Psychotic and bipolar disorder 0.22 -0.64 1.07 0.43 0.62
Only psychotic disorder 0.59 -0.16 1.33 0.38 0.12
Only bipolar disorder 1.49 1.04 1.95 0.23 1.54e-10
PTSD 1.90 1.62 2.18 0.14 2.74e-40
ASD 1.38 0.82 1.94 0.29 1.35e-06
ADHD 1.06 0.34 1.78 0.37 0.004
Personality disorder 3.21 2.81 3.60 0.20 1.20e-57
Female 0.82 0.62 1.02 0.10 8.40e-16
Non-binary/Self-defined 1.31 0.55 2.08 0.39 7.22e-04
19-25 years -3.88 -4.52 -3.24 0.33 9.39e-33
26-35 years -5.94 -6.54 -5.33 0.31 1.92e-82
36-45 years -6.53 -7.14 -5.93 0.31 4.27e-98
46-55 years -6.74 -7.34 -6.14 0.31 2.45e-106
56-65 years -7.49 -8.10 -6.88 0.31 8.88e-128
66-70 years -8.84 -9.62 -8.07 0.40 1.62e-109
71-75 years -8.41 -9.36 -7.45 0.49 2.75e-66
76+ years -8.64 -10.19 -7.08 0.79 1.93e-27
Mixed or multiple ethnic origins 0.43 -0.15 1.01 0.30 0.15
Asian or Asian British 0.41 -0.32 1.15 0.38 0.27
African or African British -0.13 -1.38 1.11 0.63 0.83
Other ethnicity 0.63 -0.43 1.69 0.54 0.24
Key worker -0.88 -1.04 -0.71 0.08 2.09e-25
Time difference: Lockdown to baseline -0.20 -0.24 -0.16 0.02 4.62e-24
Increased employment 0.00 -0.41 0.41 0.21 1.00
Furloughed -0.34 -0.64 -0.04 0.15 0.03
employment_changeEmployment not changed -0.31 -0.55 -0.08 0.12 0.009

PHQ retro

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.10 3.84 4.37 0.14 4.96e-193
phq.sum_score_retro 0.68 0.66 0.69 0.01 0.00e+00
Depressive and anxiety disorder 2.68 2.53 2.83 0.07 3.84e-277
Only depressive disorder 1.69 1.52 1.86 0.09 2.24e-81
Only anxiety disorder 1.18 0.96 1.40 0.11 9.64e-27
Eating disorders 0.79 0.56 1.01 0.12 7.75e-12
OCDs 0.46 0.24 0.67 0.11 3.82e-05
Psychotic and bipolar disorder 0.02 -0.61 0.65 0.32 0.95
Only psychotic disorder -0.05 -0.59 0.49 0.28 0.85
Only bipolar disorder 0.64 0.30 0.99 0.18 2.59e-04
PTSD 0.93 0.73 1.13 0.10 3.86e-19
ASD 0.55 0.15 0.95 0.20 0.007
ADHD 0.34 -0.19 0.86 0.27 0.21
Personality disorder 0.80 0.50 1.10 0.15 1.97e-07
Female 0.74 0.61 0.86 0.06 1.20e-30
Non-binary/Self-defined 0.54 0.03 1.05 0.26 0.04
age_category_collapsed_reordered16-18 2.82 2.46 3.17 0.18 5.88e-55
age_category_collapsed_reordered19-25 1.20 0.96 1.43 0.12 1.97e-23
age_category_collapsed_reordered36-45 -0.59 -0.79 -0.40 0.10 3.85e-09
age_category_collapsed_reordered46-55 -0.77 -0.95 -0.59 0.09 1.94e-16
age_category_collapsed_reordered56-65 -1.16 -1.35 -0.97 0.10 3.13e-32
age_category_collapsed_reordered66-70 -1.59 -1.86 -1.32 0.14 6.05e-31
age_category_collapsed_reordered71-75 -1.75 -2.05 -1.45 0.15 7.25e-30
age_category_collapsed_reordered76+ -1.77 -2.19 -1.35 0.21 1.04e-16
Mixed or multiple ethnic origins 0.12 -0.28 0.52 0.20 0.55
Asian or Asian British 0.00 -0.47 0.47 0.24 1.00
African or African British -0.43 -1.32 0.46 0.46 0.34
Other ethnicity 0.48 -0.24 1.20 0.37 0.19
Key worker 0.11 -0.02 0.24 0.07 0.10
Retired -0.19 -0.39 0.00 0.10 0.06
Student 0.44 0.15 0.74 0.15 0.003
Unemployed 0.65 0.40 0.90 0.13 2.92e-07
Time difference: Lockdown to baseline -0.22 -0.25 -0.19 0.01 4.59e-58

PHQ prepan

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 2.51 1.66 3.37 0.44 7.90e-09
phq.sum_score_prepan 0.54 0.53 0.56 0.01 0.00e+00
Depressive and anxiety disorder 1.25 0.61 1.90 0.33 1.29e-04
Only depressive disorder 0.80 0.11 1.49 0.35 0.02
Only anxiety disorder 0.20 -0.53 0.92 0.37 0.59
Eating disorders 0.95 0.63 1.27 0.16 8.00e-09
OCDs 0.51 0.21 0.82 0.15 7.98e-04
Psychotic and bipolar disorder -0.82 -1.73 0.09 0.46 0.08
Only psychotic disorder 0.14 -0.59 0.88 0.38 0.70
Only bipolar disorder 0.27 -0.17 0.72 0.23 0.23
PTSD 0.57 0.28 0.86 0.15 9.92e-05
ASD 0.66 0.06 1.25 0.30 0.03
ADHD 0.35 -0.47 1.16 0.42 0.41
Personality disorder 0.90 0.49 1.31 0.21 1.73e-05
Female 0.15 -0.12 0.41 0.13 0.28
Non-binary/Self-defined 0.28 -0.48 1.03 0.38 0.47
age_category_collapsed_reordered16-18 1.92 1.28 2.55 0.32 3.07e-09
age_category_collapsed_reordered19-25 0.88 0.54 1.23 0.18 5.57e-07
age_category_collapsed_reordered36-45 -0.26 -0.56 0.05 0.15 0.10
age_category_collapsed_reordered46-55 -0.54 -0.83 -0.24 0.15 3.83e-04
age_category_collapsed_reordered56-65 -1.03 -1.39 -0.66 0.19 3.50e-08
age_category_collapsed_reordered66-70 -1.82 -2.47 -1.17 0.33 4.80e-08
age_category_collapsed_reordered71-75 -2.31 -3.14 -1.48 0.42 4.64e-08
age_category_collapsed_reordered76+ -1.71 -3.18 -0.23 0.75 0.02
Mixed or multiple ethnic origins 0.25 -0.43 0.92 0.34 0.48
Asian or Asian British -0.70 -1.78 0.38 0.55 0.20
African or African British -0.20 -1.99 1.60 0.92 0.83
Other ethnicity 0.16 -0.87 1.19 0.53 0.76
Key worker 0.06 -0.18 0.29 0.12 0.64
Retired 0.40 -0.05 0.84 0.23 0.08
Student 0.55 0.07 1.02 0.24 0.02
Unemployed 1.42 1.05 1.80 0.19 1.81e-13
Time difference: Lockdown to baseline 0.08 0.01 0.14 0.03 0.01

PHQ retro GLAD and EDGI sensitivity

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.23 3.43 5.04 0.41 7.51e-25
phq.sum_score_retro 0.66 0.65 0.68 0.01 0.00e+00
Depressive and anxiety disorder 0.92 0.32 1.53 0.31 0.003
Only depressive disorder 0.66 0.00 1.31 0.34 0.05
Only anxiety disorder -0.35 -1.04 0.33 0.35 0.31
Eating disorders 0.83 0.52 1.14 0.16 1.11e-07
OCDs 0.40 0.11 0.69 0.15 0.006
Psychotic and bipolar disorder -0.43 -1.30 0.44 0.44 0.33
Only psychotic disorder -0.13 -0.84 0.57 0.36 0.71
Only bipolar disorder 0.28 -0.15 0.70 0.22 0.20
PTSD 0.80 0.52 1.07 0.14 1.11e-08
ASD 0.36 -0.20 0.93 0.29 0.21
ADHD 0.36 -0.42 1.14 0.40 0.37
Personality disorder 0.78 0.39 1.18 0.20 9.15e-05
Female 0.30 0.05 0.55 0.13 0.02
Non-binary/Self-defined 0.04 -0.68 0.76 0.37 0.90
age_category_collapsed_reordered16-18 1.94 1.34 2.54 0.31 3.00e-10
age_category_collapsed_reordered19-25 1.09 0.76 1.42 0.17 8.79e-11
age_category_collapsed_reordered36-45 -0.50 -0.78 -0.21 0.15 7.27e-04
age_category_collapsed_reordered46-55 -0.66 -0.94 -0.38 0.14 4.35e-06
age_category_collapsed_reordered56-65 -1.39 -1.74 -1.04 0.18 5.54e-15
age_category_collapsed_reordered66-70 -2.03 -2.65 -1.40 0.32 2.01e-10
age_category_collapsed_reordered71-75 -2.63 -3.42 -1.84 0.40 7.33e-11
age_category_collapsed_reordered76+ -2.55 -3.97 -1.13 0.72 4.29e-04
Mixed or multiple ethnic origins -0.07 -0.71 0.58 0.33 0.84
Asian or Asian British -0.29 -1.32 0.74 0.53 0.58
African or African British 0.10 -1.62 1.81 0.87 0.91
Other ethnicity 0.27 -0.71 1.25 0.50 0.59
Key worker 0.08 -0.14 0.31 0.12 0.46
Retired 0.11 -0.31 0.54 0.22 0.60
Student 0.49 0.04 0.94 0.23 0.03
Unemployed 0.81 0.45 1.17 0.19 1.20e-05
Time difference: Lockdown to baseline 0.00 -0.05 0.06 0.03 0.91

OCIR baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 24.47 21.76 27.18 1.38 3.69e-67
Depressive and anxiety disorder 2.81 1.69 3.93 0.57 9.40e-07
Only depressive disorder 0.24 -1.30 1.78 0.79 0.76
Only anxiety disorder 0.59 -0.97 2.15 0.80 0.46
Eating disorders 0.12 -1.14 1.38 0.64 0.86
OCDs 6.83 5.72 7.94 0.56 4.43e-33
Psychotic and bipolar disorder 6.66 3.70 9.61 1.51 1.03e-05
Only psychotic disorder 4.43 1.67 7.18 1.41 0.002
Only bipolar disorder 3.18 1.26 5.09 0.98 0.001
PTSD 2.60 1.50 3.70 0.56 3.96e-06
ASD 7.81 5.72 9.90 1.07 2.78e-13
ADHD 2.39 -0.38 5.15 1.41 0.09
Personality disorder 3.45 2.01 4.90 0.74 3.03e-06
Female -0.77 -1.90 0.36 0.57 0.18
Non-binary/Self-defined -1.47 -4.53 1.58 1.56 0.35
19-25 years -6.55 -8.87 -4.24 1.18 3.00e-08
26-35 years -8.19 -10.39 -5.98 1.12 4.12e-13
36-45 years -8.18 -10.43 -5.93 1.15 1.21e-12
46-55 years -8.04 -10.24 -5.83 1.13 1.11e-12
56-65 years -8.48 -10.73 -6.24 1.14 1.52e-13
66-70 years -9.11 -12.88 -5.34 1.92 2.24e-06
71-75 years -10.18 -15.42 -4.93 2.68 1.45e-04
76+ years -9.08 -18.09 -0.06 4.60 0.05
Mixed or multiple ethnic origins 0.21 -2.38 2.80 1.32 0.87
Asian or Asian British 2.61 -1.52 6.73 2.10 0.22
African or African British -0.12 -6.84 6.59 3.43 0.97
Other ethnicity 2.36 -1.58 6.30 2.01 0.24
Key worker -1.72 -2.53 -0.91 0.41 3.26e-05
Time difference: Lockdown to baseline -0.41 -0.59 -0.23 0.09 1.04e-05
Increased employment 1.67 -0.31 3.66 1.01 0.10
Furloughed -0.02 -1.40 1.36 0.70 0.98
employment_changeEmployment not changed 0.18 -0.92 1.27 0.56 0.75

OCIR retro

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 12.95 11.63 14.27 0.67 3.15e-79
ocir.sum_score_retro 0.74 0.71 0.76 0.01 0.00e+00
Depressive and anxiety disorder -1.13 -1.87 -0.39 0.38 0.003
Only depressive disorder -0.96 -1.95 0.03 0.51 0.06
Only anxiety disorder -0.18 -1.18 0.83 0.51 0.73
Eating disorders 0.05 -0.83 0.92 0.45 0.92
OCDs 1.93 1.16 2.70 0.39 9.08e-07
Psychotic and bipolar disorder 3.06 1.04 5.09 1.03 0.003
Only psychotic disorder 0.73 -1.17 2.63 0.97 0.45
Only bipolar disorder 0.41 -0.89 1.72 0.67 0.54
PTSD 0.49 -0.27 1.25 0.39 0.21
ASD 2.41 0.99 3.83 0.72 8.79e-04
ADHD 1.92 -0.04 3.88 1.00 0.05
Personality disorder 0.60 -0.48 1.68 0.55 0.28
Female -0.02 -0.75 0.71 0.37 0.96
Non-binary/Self-defined -0.31 -2.32 1.71 1.03 0.77
age_category_collapsed_reordered16-18 5.16 3.75 6.58 0.72 1.09e-12
age_category_collapsed_reordered19-25 0.15 -0.84 1.14 0.50 0.77
age_category_collapsed_reordered36-45 -0.26 -1.17 0.66 0.47 0.58
age_category_collapsed_reordered46-55 -0.01 -0.86 0.85 0.44 0.99
age_category_collapsed_reordered56-65 1.20 0.28 2.12 0.47 0.01
age_category_collapsed_reordered66-70 1.91 0.45 3.38 0.75 0.01
age_category_collapsed_reordered71-75 1.57 -0.16 3.30 0.88 0.08
age_category_collapsed_reordered76+ -0.49 -3.72 2.74 1.65 0.76
Mixed or multiple ethnic origins 1.09 -0.64 2.81 0.88 0.22
Asian or Asian British 3.72 1.25 6.19 1.26 0.003
African or African British -0.78 -6.52 4.95 2.93 0.79
Other ethnicity 1.56 -0.95 4.07 1.28 0.22
Key worker -0.09 -0.74 0.56 0.33 0.78
Retired -0.33 -1.37 0.71 0.53 0.54
Student -0.26 -1.50 0.99 0.63 0.69
Unemployed 1.38 0.38 2.38 0.51 0.007
Time difference: Lockdown to baseline -1.36 -1.48 -1.23 0.06 1.07e-95

OCIR prepan

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.32 -0.24 10.88 2.83 0.06
pcl.sum_score_prepan 0.59 0.50 0.69 0.05 1.38e-31
Depressive and anxiety disorder -4.84 -9.28 -0.40 2.26 0.03
Only depressive disorder -5.59 -10.41 -0.77 2.46 0.02
Only anxiety disorder -6.09 -10.88 -1.29 2.45 0.01
Eating disorders 1.14 -0.47 2.75 0.82 0.17
OCDs 6.27 4.89 7.64 0.70 1.14e-18
Psychotic and bipolar disorder 3.38 -0.69 7.44 2.07 0.10
Only psychotic disorder 0.48 -2.85 3.81 1.70 0.78
Only bipolar disorder 2.57 0.27 4.86 1.17 0.03
PTSD -0.12 -1.54 1.31 0.72 0.87
ASD 5.30 2.29 8.31 1.54 5.72e-04
ADHD 0.33 -4.25 4.90 2.33 0.89
Personality disorder 1.91 -0.02 3.85 0.99 0.05
Female -0.08 -1.67 1.51 0.81 0.92
Non-binary/Self-defined 1.12 -2.76 5.00 1.98 0.57
age_category_collapsed_reordered16-18 2.56 -1.23 6.36 1.94 0.19
age_category_collapsed_reordered19-25 0.72 -1.10 2.55 0.93 0.44
age_category_collapsed_reordered36-45 -0.53 -2.20 1.14 0.85 0.53
age_category_collapsed_reordered46-55 0.77 -0.87 2.41 0.84 0.36
age_category_collapsed_reordered56-65 -1.11 -3.12 0.90 1.03 0.28
age_category_collapsed_reordered66-70 -1.82 -5.71 2.06 1.98 0.36
age_category_collapsed_reordered71-75 -3.28 -8.47 1.91 2.65 0.22
age_category_collapsed_reordered76+ 0.44 -10.44 11.33 5.55 0.94
Mixed or multiple ethnic origins 2.03 -1.41 5.47 1.75 0.25
Asian or Asian British 6.17 -1.43 13.77 3.88 0.11
African or African British 7.29 -7.76 22.35 7.68 0.34
Other ethnicity 4.41 -0.67 9.48 2.59 0.09
Key worker 0.65 -0.69 1.98 0.68 0.34
Retired 2.90 0.49 5.31 1.23 0.02
Student 1.25 -1.29 3.78 1.29 0.34
Unemployed 3.78 1.93 5.64 0.95 6.51e-05
Time difference: Lockdown to baseline 0.29 -0.04 0.63 0.17 0.09

PCL baseline

Model 1b: Overlapping disorders, Adjusted

Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 13.97 13.37 14.57 0.31 0.00e+00
Depressive and anxiety disorder 5.35 5.17 5.54 0.09 0.00e+00
Only depressive disorder 2.83 2.59 3.07 0.12 9.66e-118
Only anxiety disorder 2.61 2.32 2.91 0.15 1.19e-66
Eating disorders 0.68 0.41 0.96 0.14 1.36e-06
OCDs 1.18 0.92 1.44 0.13 1.95e-18
Psychotic and bipolar disorder 1.05 0.30 1.80 0.38 0.006
Only psychotic disorder 0.73 0.08 1.38 0.33 0.03
Only bipolar disorder 1.23 0.83 1.64 0.21 1.87e-09
PTSD 2.71 2.46 2.95 0.13 1.68e-101
ASD 0.88 0.39 1.37 0.25 4.52e-04
ADHD 0.76 0.12 1.39 0.32 0.02
Personality disorder 2.69 2.35 3.03 0.18 1.15e-52
Female 0.70 0.52 0.87 0.09 6.52e-15
Non-binary/Self-defined 1.12 0.46 1.79 0.34 9.70e-04
19-25 years -2.09 -2.65 -1.53 0.29 2.37e-13
26-35 years -3.83 -4.35 -3.30 0.27 1.54e-45
36-45 years -4.42 -4.95 -3.89 0.27 2.09e-59
46-55 years -4.67 -5.20 -4.14 0.27 1.92e-67
56-65 years -5.17 -5.70 -4.64 0.27 1.97e-80
66-70 years -6.01 -6.69 -5.33 0.35 1.01e-66
71-75 years -5.71 -6.55 -4.87 0.43 1.02e-40
76+ years -5.01 -6.39 -3.63 0.70 9.99e-13
Mixed or multiple ethnic origins 0.56 0.05 1.07 0.26 0.03
Asian or Asian British 0.90 0.26 1.55 0.33 0.006
African or African British 0.60 -0.49 1.69 0.56 0.28
Other ethnicity 0.63 -0.30 1.56 0.47 0.18
Key worker -0.68 -0.83 -0.54 0.07 3.11e-20
Time difference: Lockdown to baseline 0.00 -0.03 0.03 0.02 0.99
Increased employment -0.19 -0.55 0.17 0.18 0.31
Furloughed -0.48 -0.75 -0.22 0.13 3.47e-04
employment_changeEmployment not changed -0.51 -0.72 -0.31 0.10 1.00e-06

#PCL prepan ### Model 1b: Overlapping disorders, Adjusted Model 0a + Gender_collapsed + age_category_collapsed + Ethnicity_collapsed + Time registration and baseline

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 6.29 5.43 7.15 0.44 3.13e-46
pcl.sum_score_prepan 0.50 0.48 0.52 0.01 0.00e+00
Depressive and anxiety disorder 0.64 0.01 1.27 0.32 0.05
Only depressive disorder -0.13 -0.82 0.55 0.35 0.70
Only anxiety disorder -0.65 -1.36 0.07 0.36 0.08
Eating disorders 0.43 0.11 0.75 0.16 0.008
OCDs 0.46 0.16 0.76 0.15 0.002
Psychotic and bipolar disorder -0.23 -1.12 0.65 0.45 0.61
Only psychotic disorder -0.13 -0.86 0.60 0.37 0.73
Only bipolar disorder 0.44 0.00 0.88 0.23 0.05
PTSD 0.80 0.51 1.09 0.15 5.26e-08
ASD 0.45 -0.14 1.04 0.30 0.14
ADHD 0.34 -0.48 1.16 0.42 0.41
Personality disorder 0.65 0.25 1.06 0.21 0.002
Female 0.52 0.25 0.78 0.13 1.05e-04
Non-binary/Self-defined 0.52 -0.22 1.27 0.38 0.17
age_category_collapsed_reordered16-18 1.15 0.52 1.77 0.32 3.18e-04
age_category_collapsed_reordered19-25 0.87 0.53 1.21 0.17 6.28e-07
age_category_collapsed_reordered36-45 -0.59 -0.89 -0.29 0.15 1.07e-04
age_category_collapsed_reordered46-55 -0.71 -1.00 -0.41 0.15 2.25e-06
age_category_collapsed_reordered56-65 -0.83 -1.19 -0.47 0.18 6.52e-06
age_category_collapsed_reordered66-70 -1.59 -2.24 -0.95 0.33 1.33e-06
age_category_collapsed_reordered71-75 -1.94 -2.76 -1.12 0.42 3.66e-06
age_category_collapsed_reordered76+ -1.53 -2.98 -0.07 0.74 0.04
Mixed or multiple ethnic origins 0.35 -0.31 1.02 0.34 0.30
Asian or Asian British 0.53 -0.55 1.62 0.55 0.33
African or African British 0.37 -1.39 2.14 0.90 0.68
Other ethnicity 0.19 -0.82 1.21 0.52 0.71
Key worker -0.25 -0.48 -0.01 0.12 0.04
Retired -0.03 -0.47 0.41 0.22 0.88
Student 0.27 -0.20 0.74 0.24 0.26
Unemployed 1.21 0.83 1.58 0.19 2.20e-10
Time difference: Lockdown to baseline 0.10 0.04 0.16 0.03 7.03e-04

Forest Plots

functions that assign global variables and need to be in the markdown

run regression models to get normal output

###Standardise linear variables

Run models

no explan var

###Subset retrospective data by samples

add a single “other ethnicity individual” as a jitter for NBR so this category remains included wihout adding explanation.

Create data frames and plots using functions and models generated above.

no explanatory variables

With no control for retro or prepan (no explanatory variables)

Forest plots

disorder

Warning: geom_hline(): Ignoring `mapping` because `yintercept` was provided.

Warning: geom_hline(): Ignoring `mapping` because `yintercept` was provided.

### disorder (no explan)

disorder (no PCL)

time point

Sample (retrospective only)

Sample pandemic only, no explanatory variable)

Retrospective regression models by sample

GAD

GLAD

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.07 3.37 4.77 0.36 5.58e-30
gad.sum_score_retro 0.56 0.54 0.58 0.01 0.00e+00
Depressive and anxiety disorder 1.02 0.39 1.64 0.32 0.001
Only depressive disorder -0.17 -0.85 0.51 0.34 0.62
Only anxiety disorder 0.76 0.05 1.46 0.36 0.04
Eating disorders 0.71 0.39 1.02 0.16 9.57e-06
OCDs 0.42 0.13 0.71 0.15 0.004
Psychotic and bipolar disorder 0.42 -0.44 1.28 0.44 0.34
Only psychotic disorder 0.03 -0.69 0.74 0.37 0.94
Only bipolar disorder 0.10 -0.34 0.54 0.22 0.65
PTSD 0.79 0.51 1.07 0.14 2.12e-08
ASD 0.58 0.01 1.16 0.29 0.05
ADHD 0.29 -0.50 1.08 0.40 0.47
Personality disorder 0.66 0.27 1.05 0.20 9.61e-04
Female 0.43 0.17 0.69 0.13 0.001
Non-binary/Self-defined -0.23 -0.95 0.48 0.36 0.52
age_category_collapsed_reordered16-18 0.70 0.11 1.29 0.30 0.02
age_category_collapsed_reordered19-25 0.78 0.45 1.10 0.17 2.91e-06
age_category_collapsed_reordered36-45 -0.42 -0.71 -0.12 0.15 0.005
age_category_collapsed_reordered46-55 -0.63 -0.92 -0.34 0.15 1.79e-05
age_category_collapsed_reordered56-65 -1.13 -1.50 -0.77 0.18 7.82e-10
age_category_collapsed_reordered66-70 -1.63 -2.31 -0.94 0.35 3.08e-06
age_category_collapsed_reordered71-75 -2.00 -2.88 -1.12 0.45 8.26e-06
age_category_collapsed_reordered76+ -2.11 -3.61 -0.62 0.76 0.006
Mixed or multiple ethnic origins -0.25 -0.88 0.39 0.32 0.45
Asian or Asian British 0.11 -0.94 1.15 0.53 0.84
African or African British -0.45 -2.25 1.36 0.92 0.63
Other ethnicity 0.11 -0.88 1.10 0.50 0.82
Key worker 0.41 0.18 0.64 0.12 4.09e-04
Retired 0.21 -0.24 0.67 0.23 0.36
Student 0.64 0.19 1.09 0.23 0.005
Unemployed 0.87 0.51 1.23 0.18 2.25e-06
Time difference: Lockdown to baseline -0.08 -0.19 0.02 0.05 0.13

NBR

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.22 1.04 1.40 0.09 8.29e-40
gad.sum_score_retro 0.89 0.87 0.91 0.01 0.00e+00
Depressive and anxiety disorder 1.11 0.93 1.29 0.09 1.05e-34
Only depressive disorder 0.40 0.27 0.53 0.07 4.25e-09
Only anxiety disorder 0.28 0.08 0.48 0.10 0.006
Eating disorders 0.31 0.00 0.63 0.16 0.05
OCDs 0.06 -0.34 0.47 0.21 0.75
Psychotic and bipolar disorder 0.38 -1.16 1.91 0.78 0.63
Only psychotic disorder -0.02 -0.90 0.86 0.45 0.96
Only bipolar disorder 0.66 0.01 1.31 0.33 0.05
PTSD 0.50 0.16 0.84 0.17 0.004
ASD -0.12 -0.80 0.56 0.35 0.72
ADHD -0.49 -1.32 0.35 0.43 0.26
Personality disorder -0.23 -0.83 0.36 0.30 0.44
Female 0.42 0.33 0.51 0.05 3.34e-20
Non-binary/Self-defined 0.06 -0.70 0.81 0.39 0.88
age_category_collapsed_reordered16-18 1.98 0.62 3.33 0.69 0.004
age_category_collapsed_reordered19-25 0.85 0.48 1.22 0.19 6.23e-06
age_category_collapsed_reordered36-45 -0.51 -0.71 -0.31 0.10 6.36e-07
age_category_collapsed_reordered46-55 -0.62 -0.80 -0.44 0.09 1.49e-11
age_category_collapsed_reordered56-65 -0.83 -1.01 -0.65 0.09 7.83e-20
age_category_collapsed_reordered66-70 -1.04 -1.26 -0.83 0.11 3.18e-21
age_category_collapsed_reordered71-75 -1.15 -1.38 -0.92 0.12 1.35e-22
age_category_collapsed_reordered76+ -1.06 -1.36 -0.77 0.15 1.94e-12
Mixed or multiple ethnic origins -0.25 -0.65 0.15 0.20 0.22
Asian or Asian British -0.16 -0.55 0.22 0.20 0.40
African or African British -0.05 -0.72 0.61 0.34 0.87
Other ethnicity -1.42 -3.56 0.73 1.09 0.20
Key worker 0.04 -0.07 0.16 0.06 0.45
Retired 0.02 -0.12 0.16 0.07 0.78
Student 0.23 -0.31 0.77 0.28 0.40
Unemployed -0.17 -0.49 0.15 0.16 0.29
Time difference: Lockdown to baseline -0.07 -0.15 0.02 0.04 0.11

RAMP

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.33 3.86 4.80 0.24 6.02e-71
gad.sum_score_retro 0.62 0.59 0.65 0.01 0.00e+00
Depressive and anxiety disorder 2.17 1.87 2.47 0.15 2.46e-45
Only depressive disorder 0.53 0.20 0.86 0.17 0.002
Only anxiety disorder 1.61 1.22 1.99 0.20 3.26e-16
Eating disorders 0.42 -0.06 0.90 0.24 0.08
OCDs 0.65 0.19 1.11 0.23 0.006
Psychotic and bipolar disorder 0.35 -0.83 1.53 0.60 0.57
Only psychotic disorder -0.29 -1.47 0.88 0.60 0.63
Only bipolar disorder 0.63 -0.22 1.48 0.43 0.15
PTSD 0.36 -0.06 0.78 0.22 0.09
ASD 0.92 0.19 1.65 0.37 0.01
ADHD -0.38 -1.28 0.52 0.46 0.41
Personality disorder 0.43 -0.23 1.09 0.34 0.21
Female 0.95 0.65 1.25 0.15 5.44e-10
Non-binary/Self-defined 0.68 -0.43 1.79 0.57 0.23
age_category_collapsed_reordered16-18 -0.01 -0.58 0.57 0.29 0.98
age_category_collapsed_reordered19-25 0.67 0.17 1.16 0.25 0.008
age_category_collapsed_reordered36-45 -0.44 -0.91 0.04 0.24 0.07
age_category_collapsed_reordered46-55 -1.08 -1.49 -0.66 0.21 3.76e-07
age_category_collapsed_reordered56-65 -1.39 -1.79 -0.98 0.21 2.54e-11
age_category_collapsed_reordered66-70 -1.89 -2.45 -1.33 0.29 4.47e-11
age_category_collapsed_reordered71-75 -2.31 -2.94 -1.68 0.32 9.02e-13
age_category_collapsed_reordered76+ -3.06 -3.90 -2.23 0.43 6.56e-13
Mixed or multiple ethnic origins -0.23 -1.04 0.58 0.41 0.58
Asian or Asian British -0.78 -1.59 0.02 0.41 0.06
African or African British -0.89 -2.82 1.04 0.98 0.37
Other ethnicity 0.06 -1.22 1.33 0.65 0.93
Key worker 0.10 -0.18 0.39 0.15 0.48
Retired -0.37 -0.77 0.04 0.21 0.08
Student -0.29 -0.80 0.22 0.26 0.27
Unemployed -0.06 -0.57 0.46 0.26 0.83
Time difference: Lockdown to baseline 0.16 0.02 0.31 0.08 0.03

PHQ

GLAD

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 5.11 4.36 5.85 0.38 6.22e-41
phq.sum_score_retro 0.61 0.59 0.62 0.01 0.00e+00
Depressive and anxiety disorder 0.89 0.23 1.56 0.34 0.008
Only depressive disorder 0.64 -0.07 1.36 0.37 0.08
Only anxiety disorder -0.46 -1.21 0.29 0.38 0.22
Eating disorders 0.91 0.58 1.24 0.17 8.89e-08
OCDs 0.43 0.12 0.73 0.16 0.006
Psychotic and bipolar disorder -0.50 -1.42 0.42 0.47 0.29
Only psychotic disorder 0.10 -0.66 0.87 0.39 0.79
Only bipolar disorder 0.40 -0.06 0.86 0.24 0.09
PTSD 0.75 0.46 1.04 0.15 4.90e-07
ASD 0.44 -0.17 1.05 0.31 0.15
ADHD 0.54 -0.30 1.38 0.43 0.21
Personality disorder 0.95 0.54 1.37 0.21 6.64e-06
Female 0.15 -0.13 0.43 0.14 0.28
Non-binary/Self-defined -0.19 -0.95 0.56 0.38 0.61
age_category_collapsed_reordered16-18 1.91 1.28 2.53 0.32 2.41e-09
age_category_collapsed_reordered19-25 1.05 0.70 1.39 0.18 2.90e-09
age_category_collapsed_reordered36-45 -0.45 -0.76 -0.14 0.16 0.004
age_category_collapsed_reordered46-55 -0.47 -0.78 -0.16 0.16 0.003
age_category_collapsed_reordered56-65 -1.20 -1.59 -0.82 0.20 7.72e-10
age_category_collapsed_reordered66-70 -1.66 -2.39 -0.93 0.37 7.60e-06
age_category_collapsed_reordered71-75 -2.48 -3.42 -1.54 0.48 2.44e-07
age_category_collapsed_reordered76+ -2.34 -3.93 -0.76 0.81 0.004
Mixed or multiple ethnic origins 0.15 -0.52 0.83 0.34 0.66
Asian or Asian British -0.31 -1.42 0.79 0.57 0.58
African or African British 0.18 -1.73 2.09 0.97 0.86
Other ethnicity 0.21 -0.83 1.25 0.53 0.70
Key worker 0.18 -0.06 0.42 0.12 0.15
Retired 0.33 -0.15 0.81 0.25 0.18
Student 0.59 0.11 1.06 0.24 0.02
Unemployed 1.03 0.65 1.42 0.20 1.41e-07
Time difference: Lockdown to baseline -0.05 -0.16 0.06 0.06 0.35

NBR

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 1.87 1.67 2.08 0.10 8.09e-74
phq.sum_score_retro 0.87 0.85 0.89 0.01 0.00e+00
Depressive and anxiety disorder 1.15 0.95 1.35 0.10 3.09e-30
Only depressive disorder 0.65 0.50 0.79 0.08 1.62e-17
Only anxiety disorder 0.20 -0.02 0.42 0.11 0.07
Eating disorders 0.68 0.33 1.03 0.18 1.23e-04
OCDs 0.08 -0.37 0.53 0.23 0.72
Psychotic and bipolar disorder -1.70 -3.40 0.00 0.87 0.05
Only psychotic disorder 0.49 -0.49 1.46 0.50 0.33
Only bipolar disorder 0.36 -0.36 1.09 0.37 0.33
PTSD 0.83 0.45 1.21 0.19 2.03e-05
ASD 0.10 -0.65 0.84 0.38 0.80
ADHD -0.77 -1.70 0.16 0.47 0.10
Personality disorder 0.22 -0.45 0.89 0.34 0.52
Female 0.40 0.30 0.50 0.05 6.95e-15
Non-binary/Self-defined 0.35 -0.49 1.18 0.43 0.41
age_category_collapsed_reordered16-18 3.13 1.63 4.63 0.77 4.36e-05
age_category_collapsed_reordered19-25 0.81 0.40 1.22 0.21 1.13e-04
age_category_collapsed_reordered36-45 -0.63 -0.85 -0.41 0.11 3.01e-08
age_category_collapsed_reordered46-55 -0.88 -1.08 -0.68 0.10 5.74e-18
age_category_collapsed_reordered56-65 -1.21 -1.41 -1.01 0.10 4.63e-33
age_category_collapsed_reordered66-70 -1.45 -1.69 -1.21 0.12 1.24e-32
age_category_collapsed_reordered71-75 -1.56 -1.81 -1.30 0.13 8.14e-33
age_category_collapsed_reordered76+ -1.57 -1.90 -1.24 0.17 8.83e-21
Mixed or multiple ethnic origins -0.15 -0.59 0.29 0.23 0.51
Asian or Asian British 0.06 -0.37 0.49 0.22 0.79
African or African British -0.25 -0.98 0.48 0.37 0.50
Other ethnicity -3.50 -5.87 -1.13 1.21 0.004
Key worker 0.07 -0.06 0.19 0.06 0.28
Retired -0.07 -0.23 0.08 0.08 0.35
Student -0.11 -0.71 0.49 0.31 0.71
Unemployed -0.24 -0.59 0.12 0.18 0.19
Time difference: Lockdown to baseline -0.07 -0.16 0.02 0.05 0.13

RAMP

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 4.94 4.42 5.45 0.26 1.08e-77
phq.sum_score_retro 0.61 0.58 0.63 0.01 0.00e+00
Depressive and anxiety disorder 2.78 2.45 3.11 0.17 4.13e-61
Only depressive disorder 1.19 0.83 1.56 0.19 1.62e-10
Only anxiety disorder 0.84 0.43 1.26 0.21 7.60e-05
Eating disorders 0.80 0.28 1.32 0.27 0.003
OCDs 0.43 -0.08 0.93 0.26 0.10
Psychotic and bipolar disorder 0.01 -1.28 1.29 0.66 0.99
Only psychotic disorder -0.84 -2.14 0.45 0.66 0.20
Only bipolar disorder 1.16 0.23 2.09 0.47 0.01
PTSD 0.89 0.43 1.35 0.24 1.49e-04
ASD 0.77 -0.03 1.56 0.40 0.06
ADHD -0.10 -1.08 0.88 0.50 0.84
Personality disorder 1.02 0.30 1.75 0.37 0.006
Female 0.99 0.66 1.31 0.17 3.61e-09
Non-binary/Self-defined 1.90 0.69 3.11 0.62 0.002
age_category_collapsed_reordered16-18 2.42 1.79 3.05 0.32 4.69e-14
age_category_collapsed_reordered19-25 1.35 0.81 1.88 0.27 9.34e-07
age_category_collapsed_reordered36-45 -0.57 -1.08 -0.05 0.26 0.03
age_category_collapsed_reordered46-55 -0.85 -1.31 -0.40 0.23 2.24e-04
age_category_collapsed_reordered56-65 -0.98 -1.42 -0.53 0.23 1.59e-05
age_category_collapsed_reordered66-70 -1.40 -2.01 -0.79 0.31 7.22e-06
age_category_collapsed_reordered71-75 -1.53 -2.22 -0.84 0.35 1.38e-05
age_category_collapsed_reordered76+ -2.25 -3.16 -1.34 0.46 1.28e-06
Mixed or multiple ethnic origins 0.10 -0.79 0.98 0.45 0.83
Asian or Asian British -0.37 -1.25 0.51 0.45 0.41
African or African British -0.39 -2.49 1.71 1.07 0.72
Other ethnicity 0.09 -1.31 1.50 0.72 0.90
Key worker 0.15 -0.17 0.46 0.16 0.36
Retired -0.43 -0.87 0.01 0.23 0.06
Student 0.00 -0.56 0.56 0.29 0.99
Unemployed 0.54 -0.03 1.11 0.29 0.06
Time difference: Lockdown to baseline 0.45 0.28 0.61 0.08 6.35e-08

PCL

GLAD

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 19.84 18.76 20.92 0.55 3.41e-248
pcl.sum_score_retro 0.18 0.11 0.25 0.04 7.67e-07
Depressive and anxiety disorder 0.75 -0.22 1.72 0.49 0.13
Only depressive disorder 0.31 -0.75 1.38 0.54 0.56
Only anxiety disorder -0.65 -1.76 0.47 0.57 0.25
Eating disorders 0.16 -0.25 0.56 0.20 0.44
OCDs 0.54 0.17 0.91 0.19 0.004
Psychotic and bipolar disorder 0.75 -0.33 1.84 0.55 0.17
Only psychotic disorder 1.08 0.18 1.97 0.46 0.02
Only bipolar disorder 0.81 0.24 1.39 0.29 0.005
PTSD 1.19 0.85 1.54 0.17 9.92e-12
ASD 0.87 0.16 1.57 0.36 0.02
ADHD 0.77 -0.23 1.78 0.51 0.13
Personality disorder 0.69 0.23 1.14 0.23 0.003
Female -0.24 -0.61 0.14 0.19 0.21
Non-binary/Self-defined 0.42 -0.50 1.34 0.47 0.37
age_category_collapsed_reordered16-18 1.38 0.61 2.16 0.39 4.30e-04
age_category_collapsed_reordered19-25 0.69 0.26 1.13 0.22 0.002
age_category_collapsed_reordered36-45 -0.63 -1.04 -0.21 0.21 0.003
age_category_collapsed_reordered46-55 -0.51 -0.92 -0.10 0.21 0.02
age_category_collapsed_reordered56-65 -1.21 -1.72 -0.70 0.26 3.36e-06
age_category_collapsed_reordered66-70 -2.21 -3.30 -1.12 0.56 7.24e-05
age_category_collapsed_reordered71-75 -1.68 -3.14 -0.21 0.75 0.03
age_category_collapsed_reordered76+ -4.58 -6.68 -2.48 1.07 1.94e-05
Mixed or multiple ethnic origins -0.11 -0.97 0.74 0.44 0.80
Asian or Asian British 1.75 0.31 3.20 0.74 0.02
African or African British 0.92 -1.21 3.05 1.09 0.40
Other ethnicity 1.46 -0.02 2.95 0.76 0.05
Key worker -0.24 -0.57 0.10 0.17 0.17
Retired 0.86 0.22 1.51 0.33 0.009
Student 0.65 0.04 1.25 0.31 0.04
Unemployed 1.39 0.94 1.83 0.23 1.24e-09
Time difference: Lockdown to baseline -0.18 -0.30 -0.06 0.06 0.004

NBR

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 15.58 14.20 16.97 0.71 1.25e-73
pcl.sum_score_retro 0.10 -0.09 0.29 0.10 0.30
Depressive and anxiety disorder 2.33 1.38 3.27 0.48 1.80e-06
Only depressive disorder 1.36 0.30 2.43 0.54 0.01
Only anxiety disorder 0.83 -0.63 2.28 0.74 0.27
Eating disorders 1.53 0.24 2.81 0.65 0.02
OCDs -0.47 -1.99 1.04 0.77 0.54
Psychotic and bipolar disorder 6.59 2.41 10.77 2.13 0.002
Only psychotic disorder 2.12 -2.25 6.49 2.23 0.34
Only bipolar disorder 1.60 -1.20 4.40 1.42 0.26
PTSD 2.11 0.88 3.33 0.62 7.80e-04
ASD 0.89 -2.21 3.98 1.57 0.57
ADHD 1.38 -1.77 4.54 1.61 0.39
Personality disorder 2.20 0.47 3.94 0.88 0.01
Female 0.19 -0.68 1.06 0.44 0.67
Non-binary/Self-defined -1.09 -4.64 2.47 1.81 0.55
age_category_collapsed_reordered16-18 0.76 -3.19 4.72 2.01 0.70
age_category_collapsed_reordered19-25 1.84 0.08 3.59 0.89 0.04
age_category_collapsed_reordered36-45 -1.38 -2.57 -0.18 0.61 0.02
age_category_collapsed_reordered46-55 -0.08 -1.25 1.10 0.60 0.90
age_category_collapsed_reordered56-65 -1.50 -2.78 -0.22 0.65 0.02
age_category_collapsed_reordered66-70 -0.91 -2.95 1.13 1.04 0.38
age_category_collapsed_reordered71-75 -0.94 -3.65 1.77 1.38 0.50
age_category_collapsed_reordered76+ -0.57 -3.84 2.70 1.66 0.73
Mixed or multiple ethnic origins 2.56 0.57 4.55 1.01 0.01
Asian or Asian British 0.59 -1.47 2.65 1.05 0.57
African or African British 1.89 -2.78 6.55 2.37 0.43
Other ethnicity 2.93 -5.16 11.02 4.11 0.48
Key worker 0.67 -0.23 1.56 0.46 0.15
Retired 1.29 -0.10 2.69 0.71 0.07
Student 1.20 -1.24 3.64 1.24 0.34
Unemployed 1.31 -0.28 2.90 0.81 0.11
Time difference: Lockdown to baseline -0.40 -0.91 0.10 0.26 0.12

RAMP

Indepent variable Estimate 95% CI low 95% CI up SE p value
Intercept 11.08 10.35 11.82 0.37 6.99e-168
pcl.sum_score_retro 1.05 0.95 1.15 0.05 1.08e-90
Depressive and anxiety disorder 4.00 3.57 4.44 0.22 4.05e-69
Only depressive disorder 2.03 1.51 2.55 0.27 3.21e-14
Only anxiety disorder 1.66 1.06 2.26 0.31 6.72e-08
Eating disorders 0.41 -0.26 1.07 0.34 0.23
OCDs 0.84 0.22 1.46 0.32 0.008
Psychotic and bipolar disorder 1.88 0.44 3.33 0.74 0.01
Only psychotic disorder 0.85 -0.59 2.30 0.74 0.25
Only bipolar disorder 0.20 -0.94 1.33 0.58 0.74
PTSD 2.44 1.89 2.99 0.28 7.40e-18
ASD -0.06 -1.05 0.92 0.50 0.90
ADHD 0.44 -0.85 1.73 0.66 0.51
Personality disorder 2.05 1.22 2.87 0.42 1.37e-06
Female 0.31 -0.15 0.77 0.23 0.19
Non-binary/Self-defined 1.01 -0.60 2.61 0.82 0.22
age_category_collapsed_reordered16-18 2.91 2.10 3.72 0.41 1.92e-12
age_category_collapsed_reordered19-25 1.20 0.44 1.96 0.39 0.002
age_category_collapsed_reordered36-45 -0.15 -0.88 0.58 0.37 0.68
age_category_collapsed_reordered46-55 -0.69 -1.33 -0.05 0.33 0.03
age_category_collapsed_reordered56-65 -1.46 -2.09 -0.84 0.32 4.92e-06
age_category_collapsed_reordered66-70 -1.13 -1.99 -0.27 0.44 0.01
age_category_collapsed_reordered71-75 -1.67 -2.63 -0.71 0.49 6.42e-04
age_category_collapsed_reordered76+ -1.55 -2.88 -0.21 0.68 0.02
Mixed or multiple ethnic origins 0.05 -1.15 1.24 0.61 0.94
Asian or Asian British 0.06 -1.07 1.18 0.57 0.92
African or African British -1.02 -3.67 1.63 1.35 0.45
Other ethnicity -0.70 -2.49 1.10 0.92 0.45
Key worker -0.05 -0.49 0.40 0.23 0.83
Retired -0.21 -0.84 0.42 0.32 0.51
Student 0.69 -0.08 1.45 0.39 0.08
Unemployed 2.85 2.10 3.59 0.38 1.01e-13
Time difference: Lockdown to baseline 0.44 0.21 0.66 0.11 1.47e-04

frequencies and descriptives in exclusion data

after excluding for age, gender, or MHD being NA (as in skipped or missed. Prefer not to answer was categories as it’s own option), and if they did not complete all measurement points.

sample size counts by cohort for each measurement point

pandemic change gad

Frequencies  
dat$gad.pandemic_felt_feelings  
Type: Factor  
Group: Sample = EDGI  

                        Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------- ------ --------- -------------- --------- --------------
           Much worse     10     15.38          15.38     15.38          15.38
       A little worse     32     49.23          64.62     49.23          64.62
         No different     16     24.62          89.23     24.62          89.23
      A little better      5      7.69          96.92      7.69          96.92
          Much better      2      3.08         100.00      3.08         100.00
                 <NA>      0                               0.00         100.00
                Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                         Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------- ------- --------- -------------- --------- --------------
           Much worse    2474     19.56          19.56     19.55          19.55
       A little worse    5321     42.08          61.64     42.05          61.61
         No different    3599     28.46          90.10     28.44          90.05
      A little better     854      6.75          96.85      6.75          96.80
          Much better     398      3.15         100.00      3.15          99.94
                 <NA>       7                               0.06         100.00
                Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                         Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------- ------- --------- -------------- --------- --------------
           Much worse     879      6.72           6.72      6.71           6.71
       A little worse    3853     29.45          36.17     29.42          36.13
         No different    7897     60.37          96.54     60.30          96.43
      A little better     336      2.57          99.11      2.57          99.00
          Much better     117      0.89         100.00      0.89          99.89
                 <NA>      14                               0.11         100.00
                Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                        Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------- ------ --------- -------------- --------- --------------
           Much worse   2357     27.35          27.35     27.25          27.25
       A little worse   3568     41.41          68.76     41.24          68.49
         No different   2128     24.70          93.45     24.60          93.09
      A little better    363      4.21          97.67      4.20          97.28
          Much better    201      2.33         100.00      2.32          99.61
                 <NA>     34                               0.39         100.00
                Total   8651    100.00         100.00    100.00         100.00

pandemic change phq

Frequencies  
dat$phq.pandemic_felt_feelings  
Type: Factor  
Group: Sample = EDGI  

                        Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------- ------ --------- -------------- --------- --------------
           Much worse     12     18.46          18.46     18.46          18.46
       A little worse     27     41.54          60.00     41.54          60.00
         No different     17     26.15          86.15     26.15          86.15
      A little better      6      9.23          95.38      9.23          95.38
          Much better      3      4.62         100.00      4.62         100.00
                 <NA>      0                               0.00         100.00
                Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                         Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------- ------- --------- -------------- --------- --------------
           Much worse    2282     18.09          18.09     18.04          18.04
       A little worse    5645     44.74          62.83     44.61          62.65
         No different    3217     25.50          88.33     25.42          88.07
      A little better    1034      8.20          96.53      8.17          96.25
          Much better     438      3.47         100.00      3.46          99.71
                 <NA>      37                               0.29         100.00
                Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                         Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------- ------- --------- -------------- --------- --------------
           Much worse     899      6.90           6.90      6.86           6.86
       A little worse    4305     33.04          39.94     32.87          39.74
         No different    7351     56.42          96.37     56.13          95.87
      A little better     338      2.59          98.96      2.58          98.45
          Much better     135      1.04         100.00      1.03          99.48
                 <NA>      68                               0.52         100.00
                Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                        Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------- ------ --------- -------------- --------- --------------
           Much worse   2288     26.61          26.61     26.45          26.45
       A little worse   3768     43.83          70.44     43.56          70.00
         No different   1885     21.93          92.37     21.79          91.79
      A little better    421      4.90          97.27      4.87          96.66
          Much better    235      2.73         100.00      2.72          99.38
                 <NA>     54                               0.62         100.00
                Total   8651    100.00         100.00    100.00         100.00

Ethnicity

Frequencies  
dat$Ethnicity_collapsed  
Type: Factor  
Group: Sample = EDGI  

                                         Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------- ------ --------- -------------- --------- --------------
                              European     60     92.31          92.31     92.31          92.31
      Mixed or multiple ethnic origins      3      4.62          96.92      4.62          96.92
                Asian or Asian British      1      1.54          98.46      1.54          98.46
            African or African British      0      0.00          98.46      0.00          98.46
                                 Other      1      1.54         100.00      1.54         100.00
                                  <NA>      0                               0.00         100.00
                                 Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------- ------- --------- -------------- --------- --------------
                              European   12090     95.78          95.78     95.55          95.55
      Mixed or multiple ethnic origins     276      2.19          97.96      2.18          97.73
                Asian or Asian British      98      0.78          98.74      0.77          98.51
            African or African British      37      0.29          99.03      0.29          98.80
                                 Other     122      0.97         100.00      0.96          99.76
                                  <NA>      30                               0.24         100.00
                                 Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------- ------- --------- -------------- --------- --------------
                              European    9927     97.16          97.16     75.80          75.80
      Mixed or multiple ethnic origins     118      1.15          98.32      0.90          76.70
                Asian or Asian British     126      1.23          99.55      0.96          77.66
            African or African British      46      0.45         100.00      0.35          78.02
                                 Other       0      0.00         100.00      0.00          78.02
                                  <NA>    2879                              21.98         100.00
                                 Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                                         Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------- ------ --------- -------------- --------- --------------
                              European   8124     94.32          94.32     93.91          93.91
      Mixed or multiple ethnic origins    174      2.02          96.34      2.01          95.92
                Asian or Asian British    169      1.96          98.30      1.95          97.87
            African or African British     76      0.88          99.19      0.88          98.75
                                 Other     70      0.81         100.00      0.81          99.56
                                  <NA>     38                               0.44         100.00
                                 Total   8651    100.00         100.00    100.00         100.00

Gender

Frequencies  
dat$Gender_collapsed  
Type: Factor  
Group: Sample = EDGI  

                                Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------------- ------ --------- -------------- --------- --------------
                         Male      1      1.54           1.54      1.54           1.54
                       Female     62     95.38          96.92     95.38          96.92
      Non-binary/Self-defined      2      3.08         100.00      3.08         100.00
                         <NA>      0                               0.00         100.00
                        Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                                 Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------------- ------- --------- -------------- --------- --------------
                         Male    2279     18.01          18.01     18.01          18.01
                       Female   10127     80.04          98.05     80.04          98.05
      Non-binary/Self-defined     247      1.95         100.00      1.95         100.00
                         <NA>       0                               0.00         100.00
                        Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                                 Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------------- ------- --------- -------------- --------- --------------
                         Male    5641     43.07          43.07     43.07          43.07
                       Female    7416     56.63          99.70     56.63          99.70
      Non-binary/Self-defined      39      0.30         100.00      0.30         100.00
                         <NA>       0                               0.00         100.00
                        Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                                Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------------- ------ --------- -------------- --------- --------------
                         Male   1777     20.54          20.54     20.54          20.54
                       Female   6782     78.40          98.94     78.40          98.94
      Non-binary/Self-defined     92      1.06         100.00      1.06         100.00
                         <NA>      0                               0.00         100.00
                        Total   8651    100.00         100.00    100.00         100.00

age categorical

Frequencies  
dat$age_category_collapsed  
Type: Factor  
Group: Sample = EDGI  

              Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------- ------ --------- -------------- --------- --------------
      16-18      7     10.77          10.77     10.77          10.77
      19-25     17     26.15          36.92     26.15          36.92
      26-35     21     32.31          69.23     32.31          69.23
      36-45      8     12.31          81.54     12.31          81.54
      46-55      4      6.15          87.69      6.15          87.69
      56-65      5      7.69          95.38      7.69          95.38
      66-70      3      4.62         100.00      4.62         100.00
      71-75      0      0.00         100.00      0.00         100.00
        76+      0      0.00         100.00      0.00         100.00
       <NA>      0                               0.00         100.00
      Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

               Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------- ------- --------- -------------- --------- --------------
      16-18     341      2.70           2.70      2.70           2.70
      19-25    1537     12.15          14.84     12.15          14.84
      26-35    2850     22.52          37.37     22.52          37.37
      36-45    2459     19.43          56.80     19.43          56.80
      46-55    2821     22.30          79.10     22.30          79.10
      56-65    1908     15.08          94.18     15.08          94.18
      66-70     433      3.42          97.60      3.42          97.60
      71-75     231      1.83          99.42      1.83          99.42
        76+      73      0.58         100.00      0.58         100.00
       <NA>       0                               0.00         100.00
      Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

               Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------- ------- --------- -------------- --------- --------------
      16-18      10      0.08           0.08      0.08           0.08
      19-25     291      2.22           2.30      2.22           2.30
      26-35    1165      8.90          11.19      8.90          11.19
      36-45    1440     11.00          22.19     11.00          22.19
      46-55    2644     20.19          42.38     20.19          42.38
      56-65    3901     29.79          72.17     29.79          72.17
      66-70    1967     15.02          87.19     15.02          87.19
      71-75    1265      9.66          96.85      9.66          96.85
        76+     413      3.15         100.00      3.15         100.00
       <NA>       0                               0.00         100.00
      Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

              Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------- ------ --------- -------------- --------- --------------
      16-18    697      8.06           8.06      8.06           8.06
      19-25    772      8.92          16.98      8.92          16.98
      26-35   1076     12.44          29.42     12.44          29.42
      36-45    874     10.10          39.52     10.10          39.52
      46-55   1519     17.56          57.08     17.56          57.08
      56-65   2201     25.44          82.52     25.44          82.52
      66-70    786      9.09          91.61      9.09          91.61
      71-75    514      5.94          97.55      5.94          97.55
        76+    212      2.45         100.00      2.45         100.00
       <NA>      0                               0.00         100.00
      Total   8651    100.00         100.00    100.00         100.00

Employment

Frequencies  
dat$employment_prior_covid  
Type: Character  
Group: Sample = EDGI  

                   Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------- ------ --------- -------------- --------- --------------
        Employed     16     25.40          25.40     24.62          24.62
      Key worker     23     36.51          61.90     35.38          60.00
         Retired      5      7.94          69.84      7.69          67.69
         Student      8     12.70          82.54     12.31          80.00
      Unemployed     11     17.46         100.00     16.92          96.92
            <NA>      2                               3.08         100.00
           Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                    Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------- ------- --------- -------------- --------- --------------
        Employed    3164     26.97          26.97     25.01          25.01
      Key worker    5357     45.66          72.62     42.34          67.34
         Retired    1435     12.23          84.85     11.34          78.68
         Student     673      5.74          90.59      5.32          84.00
      Unemployed    1104      9.41         100.00      8.73          92.73
            <NA>     920                               7.27         100.00
           Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                    Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------- ------- --------- -------------- --------- --------------
        Employed    3398     26.47          26.47     25.95          25.95
      Key worker    4414     34.38          60.85     33.70          59.65
         Retired    4681     36.46          97.31     35.74          95.40
         Student     106      0.83          98.14      0.81          96.20
      Unemployed     239      1.86         100.00      1.82          98.03
            <NA>     258                               1.97         100.00
           Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                   Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------- ------ --------- -------------- --------- --------------
        Employed   2345     28.45          28.45     27.11          27.11
      Key worker   2765     33.54          61.99     31.96          59.07
         Retired   1913     23.21          85.20     22.11          81.18
         Student    720      8.73          93.93      8.32          89.50
      Unemployed    500      6.07         100.00      5.78          95.28
            <NA>    408                               4.72         100.00
           Total   8651    100.00         100.00    100.00         100.00

anxiety disorders

Frequencies  
dat$anxiety_disorders  
Type: Factor  
Group: Sample = EDGI  

                            Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------- ------ --------- -------------- --------- --------------
      No anxiety disorder     27     41.54          41.54     41.54          41.54
         Anxiety disorder     38     58.46         100.00     58.46         100.00
                     <NA>      0                               0.00         100.00
                    Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                             Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------- ------- --------- -------------- --------- --------------
      No anxiety disorder    1637     13.95          13.95     12.94          12.94
         Anxiety disorder   10098     86.05         100.00     79.81          92.74
                     <NA>     918                               7.26         100.00
                    Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                             Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------- ------- --------- -------------- --------- --------------
      No anxiety disorder   11303     86.49          86.49     86.31          86.31
         Anxiety disorder    1765     13.51         100.00     13.48          99.79
                     <NA>      28                               0.21         100.00
                    Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                            Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------- ------ --------- -------------- --------- --------------
      No anxiety disorder   4210     55.69          55.69     48.66          48.66
         Anxiety disorder   3350     44.31         100.00     38.72          87.39
                     <NA>   1091                              12.61         100.00
                    Total   8651    100.00         100.00    100.00         100.00

Depressive disorders

Frequencies  
dat$depressive_disorders  
Type: Factor  
Group: Sample = EDGI  

                               Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------------------- ------ --------- -------------- --------- --------------
      No depressive disorder     18     27.69          27.69     27.69          27.69
         Depressive disorder     47     72.31         100.00     72.31         100.00
                        <NA>      0                               0.00         100.00
                       Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                                Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------------------- ------- --------- -------------- --------- --------------
      No depressive disorder    1197      9.46           9.46      9.46           9.46
         Depressive disorder   11455     90.54         100.00     90.53          99.99
                        <NA>       1                               0.01         100.00
                       Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                                Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------------------- ------- --------- -------------- --------- --------------
      No depressive disorder   10312     78.91          78.91     78.74          78.74
         Depressive disorder    2756     21.09         100.00     21.04          99.79
                        <NA>      28                               0.21         100.00
                       Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                               Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------------------- ------ --------- -------------- --------- --------------
      No depressive disorder   3734     49.39          49.39     43.16          43.16
         Depressive disorder   3826     50.61         100.00     44.23          87.39
                        <NA>   1091                              12.61         100.00
                       Total   8651    100.00         100.00    100.00         100.00

Depression and anxiety

Frequencies  
dat$depression_and_anxiety  
Type: Factor  
Group: Sample = EDGI  

                                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------------------- ------ --------- -------------- --------- --------------
      No depressive or anxiety disorder     16     24.62          24.62     24.62          24.62
        Depressive and anxiety disorder     36     55.38          80.00     55.38          80.00
               Only depressive disorder     11     16.92          96.92     16.92          96.92
                  Only anxiety disorder      2      3.08         100.00      3.08         100.00
                                   <NA>      0                               0.00         100.00
                                  Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                                           Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------------------- ------- --------- -------------- --------- --------------
      No depressive or anxiety disorder     275      2.34           2.34      2.17           2.17
        Depressive and anxiety disorder    9257     78.88          81.23     73.16          75.33
               Only depressive disorder    1362     11.61          92.83     10.76          86.10
                  Only anxiety disorder     841      7.17         100.00      6.65          92.74
                                   <NA>     918                               7.26         100.00
                                  Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                                           Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------------------- ------- --------- -------------- --------- --------------
      No depressive or anxiety disorder    9666     73.97          73.97     73.81          73.81
        Depressive and anxiety disorder    1119      8.56          82.53      8.54          82.35
               Only depressive disorder    1637     12.53          95.06     12.50          94.85
                  Only anxiety disorder     646      4.94         100.00      4.93          99.79
                                   <NA>      28                               0.21         100.00
                                  Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------------------- ------ --------- -------------- --------- --------------
      No depressive or anxiety disorder   2935     38.82          38.82     33.93          33.93
        Depressive and anxiety disorder   2551     33.74          72.57     29.49          63.41
               Only depressive disorder   1275     16.87          89.43     14.74          78.15
                  Only anxiety disorder    799     10.57         100.00      9.24          87.39
                                   <NA>   1091                              12.61         100.00
                                  Total   8651    100.00         100.00    100.00         100.00

Eating disorders

Frequencies  
dat$eating_disorders  
Type: Factor  
Group: Sample = EDGI  

                           Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------ ------ --------- -------------- --------- --------------
      No eating disorder      4      6.15           6.15      6.15           6.15
         Eating disorder     61     93.85         100.00     93.85         100.00
                    <NA>      0                               0.00         100.00
                   Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                            Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------ ------- --------- -------------- --------- --------------
      No eating disorder   11255     89.05          89.05     88.95          88.95
         Eating disorder    1384     10.95         100.00     10.94          99.89
                    <NA>      14                               0.11         100.00
                   Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                            Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------ ------- --------- -------------- --------- --------------
      No eating disorder   12897     98.51          98.51     98.48          98.48
         Eating disorder     195      1.49         100.00      1.49          99.97
                    <NA>       4                               0.03         100.00
                   Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                           Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------ ------ --------- -------------- --------- --------------
      No eating disorder   6592     93.19          93.19     76.20          76.20
         Eating disorder    482      6.81         100.00      5.57          81.77
                    <NA>   1577                              18.23         100.00
                   Total   8651    100.00         100.00    100.00         100.00

OCD

Frequencies  
dat$obsessive_compulsive_disorders  
Type: Factor  
Group: Sample = EDGI  

                                         Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------- ------ --------- -------------- --------- --------------
      No obsessive compulsive disorder     47     72.31          72.31     72.31          72.31
         Obsessive compulsive disorder     18     27.69         100.00     27.69         100.00
                                  <NA>      0                               0.00         100.00
                                 Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------- ------- --------- -------------- --------- --------------
      No obsessive compulsive disorder   11025     87.14          87.14     87.13          87.13
         Obsessive compulsive disorder    1627     12.86         100.00     12.86          99.99
                                  <NA>       1                               0.01         100.00
                                 Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------- ------- --------- -------------- --------- --------------
      No obsessive compulsive disorder   12923     98.89          98.89     98.68          98.68
         Obsessive compulsive disorder     145      1.11         100.00      1.11          99.79
                                  <NA>      28                               0.21         100.00
                                 Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                                         Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------- ------ --------- -------------- --------- --------------
      No obsessive compulsive disorder   6953     91.97          91.97     80.37          80.37
         Obsessive compulsive disorder    607      8.03         100.00      7.02          87.39
                                  <NA>   1091                              12.61         100.00
                                 Total   8651    100.00         100.00    100.00         100.00

Psychosis

Frequencies  
dat$psychotic_disorders  
Type: Factor  
Group: Sample = EDGI  

                              Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------- ------ --------- -------------- --------- --------------
      No psychotic disorder     65    100.00         100.00    100.00         100.00
         Psychotic disorder      0      0.00         100.00      0.00         100.00
                       <NA>      0                               0.00         100.00
                      Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                               Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------- ------- --------- -------------- --------- --------------
      No psychotic disorder   12238     96.83          96.83     96.72          96.72
         Psychotic disorder     401      3.17         100.00      3.17          99.89
                       <NA>      14                               0.11         100.00
                      Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                               Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------- ------- --------- -------------- --------- --------------
      No psychotic disorder   13014     99.72          99.72     99.37          99.37
         Psychotic disorder      37      0.28         100.00      0.28          99.66
                       <NA>      45                               0.34         100.00
                      Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                              Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------- ------ --------- -------------- --------- --------------
      No psychotic disorder   6922     97.85          97.85     80.01          80.01
         Psychotic disorder    152      2.15         100.00      1.76          81.77
                       <NA>   1577                              18.23         100.00
                      Total   8651    100.00         100.00    100.00         100.00

Bipolar

Frequencies  
dat$mhd.mania_hypomania_bipolar_or_manicdepression  
Type: Factor  
Group: Sample = EDGI  

                                                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------------------------------------- ------ --------- -------------- --------- --------------
      Not Mania, hypomania, bipolar or manic-depression     62     95.38          95.38     95.38          95.38
          Mania, hypomania, bipolar or manic-depression      3      4.62         100.00      4.62         100.00
                                                   <NA>      0                               0.00         100.00
                                                  Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                                                           Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------------------------------------- ------- --------- -------------- --------- --------------
      Not Mania, hypomania, bipolar or manic-depression   11778     93.09          93.09     93.08          93.08
          Mania, hypomania, bipolar or manic-depression     874      6.91         100.00      6.91          99.99
                                                   <NA>       1                               0.01         100.00
                                                  Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                                                           Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------------------------------------- ------- --------- -------------- --------- --------------
      Not Mania, hypomania, bipolar or manic-depression   12996     99.45          99.45     99.24          99.24
          Mania, hypomania, bipolar or manic-depression      72      0.55         100.00      0.55          99.79
                                                   <NA>      28                               0.21         100.00
                                                  Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                                                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------------------------------------- ------ --------- -------------- --------- --------------
      Not Mania, hypomania, bipolar or manic-depression   7320     96.83          96.83     84.61          84.61
          Mania, hypomania, bipolar or manic-depression    240      3.17         100.00      2.77          87.39
                                                   <NA>   1091                              12.61         100.00
                                                  Total   8651    100.00         100.00    100.00         100.00

PTSD

Frequencies  
dat$mhd.posttraumatic_stress_disorder_ptsd  
Type: Factor  
Group: Sample = EDGI  

                                                  Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------------------------------- ------ --------- -------------- --------- --------------
      Not Post-traumatic stress disorder (PTSD)     59     90.77          90.77     90.77          90.77
          Post-traumatic stress disorder (PTSD)      6      9.23         100.00      9.23         100.00
                                           <NA>      0                               0.00         100.00
                                          Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                                                   Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------------------------------- ------- --------- -------------- --------- --------------
      Not Post-traumatic stress disorder (PTSD)   10801     85.37          85.37     85.36          85.36
          Post-traumatic stress disorder (PTSD)    1851     14.63         100.00     14.63          99.99
                                           <NA>       1                               0.01         100.00
                                          Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                                                   Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------------------------------- ------- --------- -------------- --------- --------------
      Not Post-traumatic stress disorder (PTSD)   12837     98.23          98.23     98.02          98.02
          Post-traumatic stress disorder (PTSD)     231      1.77         100.00      1.76          99.79
                                           <NA>      28                               0.21         100.00
                                          Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                                                  Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------------------------------- ------ --------- -------------- --------- --------------
      Not Post-traumatic stress disorder (PTSD)   6859     90.73          90.73     79.29          79.29
          Post-traumatic stress disorder (PTSD)    701      9.27         100.00      8.10          87.39
                                           <NA>   1091                              12.61         100.00
                                          Total   8651    100.00         100.00    100.00         100.00

ASD

Frequencies  
dat$autism_spectrum_disorder  
Type: Factor  
Group: Sample = EDGI  

                                    Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------------- ------ --------- -------------- --------- --------------
      No autism spectrum disorder     59     90.77          90.77     90.77          90.77
         Autism spectrum disorder      6      9.23         100.00      9.23         100.00
                             <NA>      0                               0.00         100.00
                            Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                                     Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------------- ------- --------- -------------- --------- --------------
      No autism spectrum disorder   12255     96.96          96.96     96.85          96.85
         Autism spectrum disorder     384      3.04         100.00      3.03          99.89
                             <NA>      14                               0.11         100.00
                            Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                                     Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------------- ------- --------- -------------- --------- --------------
      No autism spectrum disorder   13005     99.65          99.65     99.31          99.31
         Autism spectrum disorder      46      0.35         100.00      0.35          99.66
                             <NA>      45                               0.34         100.00
                            Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                                    Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
--------------------------------- ------ --------- -------------- --------- --------------
      No autism spectrum disorder   6883     97.30          97.30     79.56          79.56
         Autism spectrum disorder    191      2.70         100.00      2.21          81.77
                             <NA>   1577                              18.23         100.00
                            Total   8651    100.00         100.00    100.00         100.00

ADHD

Frequencies  
dat$mhd.attention_deficit_hyperactivity_disorder  
Type: Factor  
Group: Sample = EDGI  

                                                                                         Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------------------------------------------------------- ------ --------- -------------- --------- --------------
      Not Attention deficit or attention deficit and hyperactivity disorder (ADD/ADHD)     63     96.92          96.92     96.92          96.92
          Attention deficit or attention deficit and hyperactivity disorder (ADD/ADHD)      2      3.08         100.00      3.08         100.00
                                                                                  <NA>      0                               0.00         100.00
                                                                                 Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                                                                                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------------------------------------------------------- ------- --------- -------------- --------- --------------
      Not Attention deficit or attention deficit and hyperactivity disorder (ADD/ADHD)   12438     98.41          98.41     98.30          98.30
          Attention deficit or attention deficit and hyperactivity disorder (ADD/ADHD)     201      1.59         100.00      1.59          99.89
                                                                                  <NA>      14                               0.11         100.00
                                                                                 Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                                                                                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------------------------------------------------------- ------- --------- -------------- --------- --------------
      Not Attention deficit or attention deficit and hyperactivity disorder (ADD/ADHD)   13019     99.75          99.75     99.41          99.41
          Attention deficit or attention deficit and hyperactivity disorder (ADD/ADHD)      32      0.25         100.00      0.24          99.66
                                                                                  <NA>      45                               0.34         100.00
                                                                                 Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                                                                                         Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
-------------------------------------------------------------------------------------- ------ --------- -------------- --------- --------------
      Not Attention deficit or attention deficit and hyperactivity disorder (ADD/ADHD)   6960     98.39          98.39     80.45          80.45
          Attention deficit or attention deficit and hyperactivity disorder (ADD/ADHD)    114      1.61         100.00      1.32          81.77
                                                                                  <NA>   1577                              18.23         100.00
                                                                                 Total   8651    100.00         100.00    100.00         100.00

Personality disorders

Frequencies  
dat$mhd.personality_disorder  
Type: Factor  
Group: Sample = EDGI  

                                 Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------------ ------ --------- -------------- --------- --------------
      Not Personality disorder     59     90.77          90.77     90.77          90.77
          Personality disorder      6      9.23         100.00      9.23         100.00
                          <NA>      0                               0.00         100.00
                         Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                                  Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------------ ------- --------- -------------- --------- --------------
      Not Personality disorder   11688     92.48          92.48     92.37          92.37
          Personality disorder     951      7.52         100.00      7.52          99.89
                          <NA>      14                               0.11         100.00
                         Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                                  Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------------ ------- --------- -------------- --------- --------------
      Not Personality disorder   12975     99.42          99.42     99.08          99.08
          Personality disorder      76      0.58         100.00      0.58          99.66
                          <NA>      45                               0.34         100.00
                         Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                                 Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
------------------------------ ------ --------- -------------- --------- --------------
      Not Personality disorder   6779     95.83          95.83     78.36          78.36
          Personality disorder    295      4.17         100.00      3.41          81.77
                          <NA>   1577                              18.23         100.00
                         Total   8651    100.00         100.00    100.00         100.00

Controls

Frequencies  
dat$control  
Type: Factor  
Group: Sample = EDGI  

                   Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------- ------ --------- -------------- --------- --------------
      No control     64     98.46          98.46     98.46          98.46
         Control      1      1.54         100.00      1.54         100.00
            <NA>      0                               0.00         100.00
           Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                    Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------- ------- --------- -------------- --------- --------------
      No control   12485     98.90          98.90     98.67          98.67
         Control     139      1.10         100.00      1.10          99.77
            <NA>      29                               0.23         100.00
           Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                    Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------- ------- --------- -------------- --------- --------------
      No control    3812     29.19          29.19     29.11          29.11
         Control    9247     70.81         100.00     70.61          99.72
            <NA>      37                               0.28         100.00
           Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                   Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
---------------- ------ --------- -------------- --------- --------------
      No control   4987     66.27          66.27     57.65          57.65
         Control   2538     33.73         100.00     29.34          86.98
            <NA>   1126                              13.02         100.00
           Total   8651    100.00         100.00    100.00         100.00

Dont know or prefer not to say

Frequencies  
dat$DidNotRespondMHD  
Type: Factor  
Group: Sample = EDGI  

                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------- ------ --------- -------------- --------- --------------
      Prefer not to say      0      0.00           0.00      0.00           0.00
       Responded to MHD     65    100.00         100.00    100.00         100.00
                   <NA>      0                               0.00         100.00
                  Total     65    100.00         100.00    100.00         100.00

Group: Sample = GLAD  

                           Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------- ------- --------- -------------- --------- --------------
      Prefer not to say       1      0.01           0.01      0.01           0.01
       Responded to MHD   12652     99.99         100.00     99.99         100.00
                   <NA>       0                               0.00         100.00
                  Total   12653    100.00         100.00    100.00         100.00

Group: Sample = NBR  

                           Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------- ------- --------- -------------- --------- --------------
      Prefer not to say       0      0.00           0.00      0.00           0.00
       Responded to MHD   13096    100.00         100.00    100.00         100.00
                   <NA>       0                               0.00         100.00
                  Total   13096    100.00         100.00    100.00         100.00

Group: Sample = RAMP  

                          Freq   % Valid   % Valid Cum.   % Total   % Total Cum.
----------------------- ------ --------- -------------- --------- --------------
      Prefer not to say   1085     12.54          12.54     12.54          12.54
       Responded to MHD   7566     87.46         100.00     87.46         100.00
                   <NA>      0                               0.00         100.00
                  Total   8651    100.00         100.00    100.00         100.00

T tests

retrospective OPHQ 9 vs baseline.

Notes: We use the default (Welch’s) t-test (to account for non equal variance)


    Paired t-test

data:  datgladedgi$phq.sum_score_base and datgladedgi$phq.sum_score_retro
t = 59.941, df = 10902, p-value < 2.2e-16
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
 3.031335 3.236297
sample estimates:
mean of the differences 
               3.133816 

    Paired t-test

data:  datgladedgi$gad.sum_score_base and datgladedgi$gad.sum_score_retro
t = 54.752, df = 10924, p-value < 2.2e-16
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
 2.603998 2.797375
sample estimates:
mean of the differences 
               2.700686